[1]陆智豪,陈立民,王颖赞,等.外泌体微RNA治疗骨关节炎研究进展[J].新乡医学院学报,2023,40(2):187-191.[doi:10.7683/xxyxyxb.2023.02.017]
 LU Zhihao,CHEN Limin,WANG Yingzan,et al.Research progress of exosomal microRNA in the treatment of osteoarthritis[J].Journal of Xinxiang Medical University,2023,40(2):187-191.[doi:10.7683/xxyxyxb.2023.02.017]
点击复制

外泌体微RNA治疗骨关节炎研究进展
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年2期
页码:
187-191
栏目:
综述
出版日期:
2023-02-05

文章信息/Info

Title:
Research progress of exosomal microRNA in the treatment of osteoarthritis
作者:
陆智豪1陈立民1王颖赞1曾平2
(1.广西中医药大学,广西 南宁 530001;2.广西中医药大学第一附属医院仙葫院区骨病创伤骨科,广西 南宁 530023)
Author(s):
LU Zhihao1CHEN Limin1WANG Yingzan1ZENG Ping2
(1.Guangxi University of Chinese Medicine,Nanning 530001,Guangxi Province,China;2.Department of Orthopedics of Osteopathy and Trauma,Xianhu Branch,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi Province,China)
关键词:
骨关节炎外泌体微RNA
Keywords:
osteoarthritisexosomemicroRNA
分类号:
R684.3
DOI:
10.7683/xxyxyxb.2023.02.017
文献标志码:
A
摘要:
骨关节炎是骨科常见的顽固性疾病之一,因其高发病率、高致残率,给患者和社会带来沉重的负担。随着组织工程领域的飞速发展,外泌体治疗骨关节炎的潜力已得到证实。其中,外泌体特异性微RNA(miRNA)可抑制软骨降解和滑膜炎症、促进软骨下骨重塑,从而缓解甚至逆转骨关节炎的病理改变。本文对外泌体miRNA治疗对骨关节炎患者软骨、滑膜、软骨细胞外基质及软骨下骨的影响进行综述,以期为临床上应用外泌体miRNA治疗骨关节炎提供参考。
Abstract:
Osteoarthritis is one of the common intractable diseases in orthopedics department,which imposes heavy burden to patients and society due to its high prevalence and morbidity.With the rapid development of tissue engineering,the potential of exosomes in the treatment of osteoarthritis has been confirmed.Among them,exosome specific microRNA(miRNA) can inhibit cartilage degradation and synovitis,promote subchondral bone remodeling,thereby alleviating or even reversing the pathological changes of osteoarthritis.This paper reviews the effects of exosomal miRNA on cartilage,synovial membrane,chondrocyte extracellular matrix,and subchondral bone of patients with osteoarthritis,in order to provide reference for the application of exosome miRNA in the treatment of osteoarthritis in clinic.

参考文献/References:

[1] VAN DEN BOSCH M H J.Osteoarthritis year in review 2020:biology[J].Osteoarthritis Cartilage,2021,29(2):143-150.
[2] PRIMORAC D,MOLNAR V,ROD E,et al.Knee osteoarthritis:a review of pathogenesis and state-of-the-art non-operative therapeutic considerations[J].Genes (Basel),2020,11(8):854.
[3] HUNTER D J.Pharmacologic therapy for osteoarthritis:the era of disease modification[J].Nat Rev Rheumatol,2011,7(1):13-22.
[4] GREGORI D,GIACOVELLI G,MINTO C,et al.Association of pharmacological treatments with long-term pain control in patients with knee osteoarthritis:a systematic review and meta-analysis[J].JAMA,2018,320(24):2564-2579.
[5] HAN Y,LI X,ZHANG Y,et al.Mesenchymal stem cells for regenerative medicine[J].Cells,2019,8(8):886.
[6] ZHANG Y,LIU Y,LIU H,et al.Exosomes:biogenesis,biologic function and clinical potential[J].Cell Biosci,2019,9:19.
[7] ASGHAR S,LITHERLAND G J,LOCKHART J C,et al.Exosomes in intercellular communication and implications for osteoarthritis[J].Rheumatology (Oxford),2020,59(1):57-68.
[8] DE ABREU R C,FERNANDES H,DA COSTA MARTINS P A,et al.Native and bioengineered extracellular vesicles for cardiovascular therapeutics[J].Nat Rev Cardiol,2020,17(11):685-697.
[9] ZHAO X,ZHAO Y,SUN X,et al.Immunomodulation of MSCs and MSC-derived extracellular vesicles in osteoarthritis[J].Front Bioeng Biotechnol,2020,8:575057.
[10] WANG M,YUAN Z,MA N,et al.Advances and prospects in stem cells for cartilage regeneration[J].Stem Cells Int,2017,2017:4130607.
[11] ASPDEN R M,SAUNDERS F R.Osteoarthritis as an organ disease:from the cradle to the grave[J].Eur Cell Mater,2019,37:74-87.
[12] WANG Z,YAN K,GE G,et al.Exosomes derived from miR-155-5p-overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration,attenuating apoptosis,and modulating extracellular matrix secretion in chondrocytes[J].Cell Biol Toxicol,2021,37(1):85-96.
[13] XU M,FENG M,PENG H,et al.Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis[J].Biochem Biophys Res Commun,2020,528(1):179-185.
[14] LIN T,WU N,WANG L,et al.Inhibition of chondrocyte apoptosis in a rat model of osteoarthritis by exosomes derived from miR-140-5p-overexpressing human dental pulp stem cells[J].Int J Mol Med,2021,47(3):7.
[15] QIU B,XU X,YI P,et al.Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways[J].J Cell Mol Med,2020,24(18):10855-10865.
[16] DENG Z,JIA Y,LIU H,et al.RhoA/ROCK pathway:implication in osteoarthritis and therapeutic targets[J].Am J Transl Res,2019,11(9):5324-5331.
[17] JIMI E,FEI H,NAKATOMI C.NF-κB signaling regulates physiological and pathological chondrogenesis[J].Int J Mol Sci,2019,20(24):6275.
[18] HE L,HE T,XING J,et al.Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis[J].Stem Cell Res Ther,2020,11(1):276.
[19] DONG J,LI L,FANG X,et al.Exosome-encapsulated microRNA-127-3p released from bone marrow-derived mesenchymal stem cells alleviates osteoarthritis through regulating CDH11- mediated Wnt/β-catenin pathway[J].J Pain Res,2021,14:297-310.
[20] AN S,HU H,LI Y,et al.Pyroptosis plays a role in osteoarthritis[J].Aging Dis,2020,11(5):1146-1157.
[21] ZHANG H,JI L,YANG Y,et al.The therapeutic effects of treadmill exercise on osteoarthritis in rats by inhibiting the HDAC3/NF-KappaB pathway in vivo and in vitro[J].Front Physiol,2019,10:1060.
[22] XU H,XU B.BMSC-derived exosomes ameliorate osteoarthritis by inhibiting pyroptosis of cartilage via delivering miR-326 targeting HDAC3 and STAT1//NF-κB p65 to chondrocytes[J].Mediators Inflamm,2021,2021:9972805.
[23] LUO P,GAO F,NIU D,et al.The role of autophagy in chondrocyte metabolism and osteoarthritis:a comprehensive research review[J].Biomed Res Int,2019,2019:5171602.
[24] JUNG C H,RO S H,CAO J,et al.mTOR regulation of autophagy[J].FEBS Lett,2010,584(7):1287-1295.
[25] CHANG J,WANG W,ZHANG H,et al.The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis[J].Int J Mol Med,2013,32(6):1311-1318.
[26] WU J,KUANG L,CHEN C,et al.miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis[J].Biomaterials,2019,206:87-100.
[27] SUN H,HU S,ZHANG Z,et al.Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells[J].J Cell Biochem,2019,120(1):171-181.
[28] HOSSEINI-FARAHABADI S,GEETHA-LOGANATHAN P,FU K,et al.Dual functions for WNT5A during cartilage development and in disease[J].Matrix Biol,2013,32(5):252-264.
[29] HUANG G,CHUBINSKAYA S,LIAO W,et al.Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes[J].Osteoarthritis Cartilage,2017,25(9):1505-1515.
[30] MAO G,ZHANG Z,HU S,et al.Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A[J].Stem Cell Res Ther,2018,9(1):247.
[31] TAO S C,YUAN T,ZHANG Y L,et al.Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model[J].Theranostics,2017,7(1):180-195.
[32] KOELLING S,KRUEGEL J,IRMER M,et al.Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis[J].Cell Stem Cell,2009,4(4):324-335.
[33] WANG R,JIANG W,ZHANG L,et al.Intra-articular delivery of extracellular vesicles secreted by chondrogenic progenitor cells from MRL/MpJ superhealer mice enhances articular cartilage repair in a mouse injury model[J].Stem Cell Res Ther,2020,11(1):93.
[34] KRENN V,MORAWIETZ L,BURMESTER G R,et al.Synovitis score:discrimination between chronic low-grade and high-grade synovitis[J].Histopathology,2006,49(4):358-364.
[35] DOMENIS R,ZANUTEL R,CAPONNETTO F,et al.Characterization of the proinflammatory profile of synovial fluid-derived exosomes of patients with osteoarthritis[J].Mediators Inflamm,2017,2017:4814987.
[36] JIN Z,REN J,QI S.Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2[J].Int Immunopharmacol,2020,78:105946.
[37] JIN Z,REN J,QI S.Exosomal miR-9-5p secreted by bone marrow-derived mesenchymal stem cells alleviates osteoarthritis by inhibiting syndecan-1[J].Cell Tissue Res,2020,381(1):99-114.
[38] LUO P,JIANG C,JI P,et al.Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p/mTOR[J].Stem Cell Res Ther,2019,10(1):216.
[39] NI Z,KUANG L,CHEN H,et al.The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis[J].Cell Death Dis,2019,10(7):522.
[40] HODGKINSON T,KELLY D C,CURTIN C M,et al.Mechanosignalling in cartilage:an emerging target for the treatment of osteoarthritis[J].Nat Rev Rheumatol,2022,18(2):67-84.
[41] GU X D,WEI L,LI P C,et al.Adenovirus-mediated transduction with histone deacetylase 4 ameliorates disease progression in an osteoarthritis rat model[J].Int Immunopharmacol,2019,75:105752.
[42] MAO G,HU S,ZHANG Z,et al.Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8[J].J Cell Mol Med,2018,22(11):5354-5366.
[43] DONELL S.Subchondral bone remodelling in osteoarthritis[J].EFORT Open Rev,2019,4(6):221-229.
[44] POURAKBARI R,KHODADADI M,AGHEBATI-MALEKI A,et al.The potential of exosomes in the therapy of the cartilage and bone complications;emphasis on osteoarthritis[J].Life Sci,2019,236:116861.
[45] ZHOU Y,MING J,LI Y,et al.Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis[J].Cell Death Discov,2021,7(1):37.
[46] MAEHARA M,TOYODA E,TAKAHASHI T,et al.Potential of exosomes for diagnosis and treatment of joint disease:towards a point-of-care therapy for osteoarthritis of the knee[J].Int J Mol Sci,2021,22(5):2666.
[47] WU X,CRAWFORD R,XIAO Y,et al.Osteoarthritic subchondral bone release exosomes that promote cartilage degeneration[J].Cells,2021,10(2):251.

相似文献/References:

[1]童敏,高戈,高洁生,等.白藜芦醇对骨关节炎模型兔关节液中一氧化氮水平的影响 [J].新乡医学院学报,2007,24(01):049.
[2]梁春艳,邢海洲.外泌体的形成、功能及应用研究进展[J].新乡医学院学报,2021,38(1):085.[doi:10.7683/xxyxyxb.2021.01.019]
[3]智佳佳,杜朝政,王 越,等.微RNA和信号通路在骨关节炎病理机制中的作用研究进展[J].新乡医学院学报,2021,38(10):982.[doi:10.7683/xxyxyxb.2021.10.017]
[4]李 刚,籍胤玺,侯晓东.盐酸多奈哌齐对骨关节炎大鼠软骨组织中肿瘤坏死因子-α和解整链蛋白金属蛋白酶-5表达的影响[J].新乡医学院学报,2021,38(8):701.[doi:10.7683/xxyxyxb.2021.08.001]
 LI Gang,JI Yinxi,HOU Xiaodong.Effect of donepezil hydrochloride on the expression of tumor necrosis factor-α and a disintegrin and metalloproteinase with thrombospondin motifs-5 in cartilage tissues of rats with osteoarthritis[J].Journal of Xinxiang Medical University,2021,38(2):701.[doi:10.7683/xxyxyxb.2021.08.001]
[5]郭瑞敏,曹毓琳,程世翔,等.间充质干细胞源性外泌体在呼吸系统疾病中的应用与机制研究进展[J].新乡医学院学报,2021,38(11):1084.[doi:10.7683/xxyxyxb.2021.11.017]
[6]丁韶龙,康 波,李志军.膝骨关节炎患者全膝关节置换后关节功能恢复影响因素分析[J].新乡医学院学报,2020,37(6):563.[doi:10.7683/xxyxyxb.2020.06.014]
 DING Shaolong,KANG Bo,LI Zhijun.Influence factors of knee joint function rehabilitation after total knee arthroplasty in patients with knee osteoarthritis[J].Journal of Xinxiang Medical University,2020,37(2):563.[doi:10.7683/xxyxyxb.2020.06.014]
[7]张高丽,邓予晖,王晓宇,等.外泌体微小核糖核酸在心肌梗死诊断及干细胞治疗中的研究进展[J].新乡医学院学报,2020,37(9):890.[doi:10.7683/xxyxyxb.2020.09.020]
[8]崔世红,吕晓峰,刘 灵,等.外泌体在宫颈癌发病及诊断与治疗中的研究进展[J].新乡医学院学报,2018,35(5):444.[doi:10.7683/xxyxyxb.2018.05.023]
 N/A.N/A[J].Journal of Xinxiang Medical University,2018,35(2):444.[doi:10.7683/xxyxyxb.2018.05.023]
[9]王志霞,杨 洋,刘 燕,等.外泌体在慢性阻塞性肺疾病发生发展中的作用研究进展[J].新乡医学院学报,2022,39(2):192.[doi:10.7683/xxyxyxb.2022.02.019]
 WANG Zhixia,YANG Yang,LIU Yan,et al.Research progress of exosomes in the occurrence and development of chronic obstructive pulmonary disease[J].Journal of Xinxiang Medical University,2022,39(2):192.[doi:10.7683/xxyxyxb.2022.02.019]
[10]石卓林,杨晓花,袁晓梅.特发性肺纤维化患者血清外泌体microRNA表达谱的变化及临床意义[J].新乡医学院学报,2022,39(5):481.[doi:10.7683/xxyxyxb.2022.05.016]
 SHI Zhuolin,YANG Xiaohua,YUAN Xiaomei.Changes and clinical significance of serum exosomal microRNA expression in patients with idiopathic pulmonary fibrosis[J].Journal of Xinxiang Medical University,2022,39(2):481.[doi:10.7683/xxyxyxb.2022.05.016]

更新日期/Last Update: 2023-02-05