[1]智佳佳,杜朝政,王 越,等.微RNA和信号通路在骨关节炎病理机制中的作用研究进展[J].新乡医学院学报,2021,38(10):982-985.[doi:10.7683/xxyxyxb.2021.10.017]
点击复制

微RNA和信号通路在骨关节炎病理机制中的作用研究进展
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年10
页码:
982-985
栏目:
综述
出版日期:
2021-10-05

文章信息/Info

作者:
智佳佳杜朝政王 越王宇泽
(山西医科大学第二医院骨科,山西 太原 030001)
关键词:
骨关节炎微RNA信号通路细胞凋亡细胞外基质
分类号:
R684.3
DOI:
10.7683/xxyxyxb.2021.10.017
文献标志码:
A
摘要:
骨关节炎是世界上致残率较高的慢性疾病之一,年龄、肥胖、外伤、遗传等危险因素均可引发骨关节炎,其发病机制尚未完全明确。微RNA是一类非编码小分子单链RNA,其作为一种调控因子可调控特定靶基因的表达。多种信号通路在骨关节炎的发生、发展中起重要作用,微RNA可通过不同的信号通路参与骨关节炎的病理发展,涉及基因表达、炎症应答、细胞增殖和凋亡、细胞外基质的合成和降解等。本文就微RNA和信号通路在骨关节炎病理机制中的作用进行综述,旨在为骨关节炎的研究和诊疗提供新方向。

参考文献/References:

[1] O′NEILL T W,MCCABE P S,MCBETH J.Update on the epide-miology,risk factors and disease outcomes of osteoarthritis[J].Best Pract Res Clin Rheumatol,2018,32(2):312-326.
[2] 丁韶龙,康波,李志军.膝骨关节炎患者全膝关节置换后关节功能恢复影响因素分析[J].新乡医学院学报,2020,37(6):563-565.
[3] ABRAMOFF B,CALDERA F E.Osteoarthritis:pathology,diagnosis,and treatment options[J].Med Clin North Am,2020,104(2):293-311.
[4] 王进娜,刘璐,赵洛鹏,等.膝骨关节炎炎性因子及信号通路的研究进展[J].中国骨伤,2020,33(4):388-392.
[5] JIANG L,ZHU J.Review of miRNA-disease association prediction[J].Curr Protein Pept Sci,2020,21(11):1044-1053.
[6] COUTINHO D E ALMEIDA R,RAMOS Y F M,MAHFOUZ A,et al.RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage[J].Ann Rheum Dis,2019,78(2):270-277.
[7] HUNTER D J,BIERMA-ZEINSTRA S.Osteoarthritis[J].Lancet,2019,393(10182):1745-1759.
[8] LAGARTO J L,NICKDEL M B,KELLY D J,et al.Autofluorescence lifetime reports cartilage damage in osteoarthritis[J].Sci Rep,2020,10(1):2154.
[9] OUYANG Z,WEI K.miRNA in cardiac development and regeneration[J].Cell Regen,2021,10(1):14.
[10] MCALINDEN A,IM G I.MicroRNAs in orthopaedic research:disease associations,potential therapeutic applications,and perspectives[J].J Orthop Res,2018,36(1):33-51.
[11] WANG X,NING Y,ZHOU B,et al.Integrated bioinformatics analysis of the osteoarthritis associated microRNA expression signature[J].Mol Med Rep,2018,17(1):1833-1838.
[12] CONG L,ZHU Y,TU G.A bioinformatic analysis of microRNAs role in osteoarthritis[J].Osteoarthritis Cartilage,2017,25(8):1362-1371.
[13] BORGONIO CUADRA V M,GONZLEZ-HUERTA N C,ROMERO-CRDOBA S,et al.Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways[J].PLoS One,2014,9(6):e97690.
[14] KOPA N' SKA M,SZALA D,CZECH J,et al.MiRNA expression in the cartilage of patients with osteoarthritis[J].J Orthop Surg Res,2017,12(1):51.
[15] ZHANG S,AN Q,HU P,et al.Core regulatory RNA molecules identified in articular cartilage stem/progenitor cells during osteoarthritis progression[J].Epigenomics,2019,11(6):669-684.
[16] JIMI E,FEI H,NAKATOMI C.NF-κB signa ling regulates physiological and pathological chondrogenesis[J].Int J Mol Sci,2019,20(24):6275.
[17] OLIVOTTO E,OTERO M,MARCU K B,et al.Pathophysiology of osteoarthritis:canonical NF-κB/ IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation[J].RMD Open,2015,1(Suppl 1):e000061.
[18] CHELESCHI S,TENTI S,MONDANELLI N,et al.MicroRNA-34a and microRNA-181a mediate visfatin-induced apoptosis and oxidative stress via NF-κB pathway in human osteoarthritic chondrocytes[J].Cells,2019,8(8):874.
[19] DING Y,WANG L,ZHAO Q,et al.MicroRNA-93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF-κB signaling pathway[J].Int J Mol Med,2019,43(2):779-790.
[20] ZHANG W,CHENG P,HU W,et al.Inhibition of microRNA-384-5p alleviates osteoarthritis through its effects on inhibiting apoptosis of cartilagecells via the NF-κB signaling pathway by targeting SOX9[J].Cancer Gene Ther,2018,25(11-12):326-338.
[21] MAO G,WU P,ZHANG Z,et al.MicroRNA-92a-3p regulates aggrecanase-1 and aggrecanase-2 expression in chondrogenesis and IL-1β-induced catabolism in human articular chondrocytes[J].Cell Physiol Biochem,2017,44(1):38-52.
[22] WEI Z J,LIU J,QIN J.miR-138 suppressed the progression of osteoarthritis mainly through targeting p65[J].Eur Rev Med Pharmacol Sci,2017,21(9):2177-2184.
[23] LORIES R J,MONTEAGUDO S.Review article:is Wnt signaling an attractive target for the treatment of osteoarthritis[J].Rheumatol Ther,2020,7(2):259-270.
[24] HU S,MAO G,ZHANG Z,et al.MicroRNA-320c inhibits deve-lopment of osteoarthritis through downregulation of canonical Wnt signaling pathway[J].Life Sci,2019,228:242-250.
[25] ZHANG Y,HUANG X,YUAN Y.MicroRNA-410 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells through down-regulating Wnt3a[J].Am J Transl Res,2017,9(1):136-145.
[26] MAO G,ZHANG Z,HU S,et al.Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A[J].Stem Cell Res Ther,2018,9(1):247.
[27] XU W,GAO P,ZHANG Y,et al.Micro RNA-138 induces cell survival and reduces WNT/β-catenin signaling of osteoarthritis chondrocytes through NEK2[J].IUBMB Life,2019,71(9):1355-1366.
[28] QIN W,CAO L,MASSEY I Y.Role of PI3K/Akt signaling pathway in cardiac fibrosis[J].Mol Cell Biochem,2021,Epub ahead of print.DOI:10.1007/s11010-021-04219-w.
[29] SUN K,LUO J,GUO J,et al.The PI3K/AKT/mTOR signaling pathway in osteoarthritis:a narrative review[J].Osteoarthritis Cartilage,2020,28(4):400-409.
[30] LI F,YAO J,HAO Q,et al.miRNA-103 promotes chondrocyte apoptosis by down-regulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis[J].Biosci Rep,2019,39(10):BSR20191255.
[31] CAI C,MIN S,YAN B,et al.MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling[J].Aging (Albany NY),2019,11(16):6371-6384.
[32] TAO H,CHENG L,YANG R.Downregulation of miR-34a promotes proliferation and inhibits apoptosis of rat osteoarthritic cartilage cells by activating PI3K/Akt pathway[J].Clin Interv Aging,2020,15:373-385.
[33] LU J,JI M L,ZHANG X J,et al.MicroRNA-218-5p as a potential target for the treatment of human osteoarthritis[J].Mol Ther,2017,25(12):2676-2688.
[34] ZHAO X,WANG T,CAI B,et al.MicroRNA-495 enhances chondrocyte apoptosis,senescence and promotes the progression of osteoarthritis by targeting AKT1[J].Am J Transl Res,2019,11(4):2232-2244.
[35] TENA G.Seeing MAPK activity[J].Nat Plants,2019,5(2):127.
[36] WU Y H,LIU W,ZHANG L,et al.Effects of microRNA-24 targeting C-myc on apoptosis,proliferation,and cytokine expressions in chondrocytes of rats with osteoarthritis via MAPK signaling pathway[J].J Cell Biochem,2018,119(10):7944-7958.
[37] WU J,TAO Y,SHANG A,et al.Effect of the interaction between MiR-200b-3p and DNMT3A on cartilage cells of osteoarthritis patients[J].J Cell Mol Med,2017,21(10):2308-2316.
[38] XIANG Y,LI Y,YANG L,et al.miR-142-5p as a CXCR4-targeted microRNA attenuates SDF-1-induced chondrocyte apoptosis and cartilage degradation via inactivating MAPK signaling pathway[J].Biochem Res Int,2020,2020:4508108.
[39] WANG J,CHEN L,JIN S,et al.MiR-98 promotes chondrocyte apoptosis by decreasing Bcl-2 expression in a rat model of osteoarthritis[J].Acta Biochim Biophys Sin (Shanghai),2016,48(10):923-929.
[40] ZHANG M,WANG Z,Li B,et al.Identification of microRNA-363-3p as an essential regulator of chondrocyte apoptosis in osteoarthritis by targeting NRF1 through the p53-signaling pathway[J].Mol Med Rep,2020,21(3):1077-1088
[41] YU H T,GU C Z,CHEN J Q.MiR-9 facilitates cartilage regeneration of osteoarthritis in rabbits through regulating Notch signaling pathway[J].Eur Rev Med Pharmacol Sci,2019,23(12):5051-5058.
[42] ZOU L X,YU L,ZHAO X M,et al.MiR-375 mediates chondrocyte metabolism and oxidative stress in osteoarthritis mouse models through the JAK2/STAT3 signaling pathway[J].Cells Tissues Organs,2019,208(1-2):13-14.

相似文献/References:

[1]童敏,高戈,高洁生,等.白藜芦醇对骨关节炎模型兔关节液中一氧化氮水平的影响 [J].新乡医学院学报,2007,24(01):049.
[2]杨 龙,刘春明,王正飞,等.银杏叶提取物对大鼠心肌缺血再灌注损伤的保护作用及机制[J].新乡医学院学报,2021,38(11):1011.[doi:10.7683/xxyxyxb.2021.11.003]
 YANG Long,LIU Chunming,WANG Zhengfei,et al.Protective role and mechnism of Ginkgo biloba extract on myocardial ischemia-reperfusion injury in rats[J].Journal of Xinxiang Medical University,2021,38(10):1011.[doi:10.7683/xxyxyxb.2021.11.003]
[3]李 刚,籍胤玺,侯晓东.盐酸多奈哌齐对骨关节炎大鼠软骨组织中肿瘤坏死因子-α和解整链蛋白金属蛋白酶-5表达的影响[J].新乡医学院学报,2021,38(8):701.[doi:10.7683/xxyxyxb.2021.08.001]
 LI Gang,JI Yinxi,HOU Xiaodong.Effect of donepezil hydrochloride on the expression of tumor necrosis factor-α and a disintegrin and metalloproteinase with thrombospondin motifs-5 in cartilage tissues of rats with osteoarthritis[J].Journal of Xinxiang Medical University,2021,38(10):701.[doi:10.7683/xxyxyxb.2021.08.001]
[4]梁文辉,朱会芳,王志慧,等.微RNA调控乳腺癌耐药性研究进展[J].新乡医学院学报,2021,38(6):597.[doi:10.7683/xxyxyxb.2021.06.022]
[5]张雪儿,郑 娜,梁紫君,等.微RNA在血管性认知障碍中的作用研究进展[J].新乡医学院学报,2021,38(9):897.[doi:10.7683/xxyxyxb.2021.09.022]
[6]韩克丽,赵国安,朱 丽,等.微RNA调节心脏重构的病理生理机制研究进展[J].新乡医学院学报,2021,38(12):1200.[doi:10.7683/xxyxyxb.2021.12.019]
[7]丁韶龙,康 波,李志军.膝骨关节炎患者全膝关节置换后关节功能恢复影响因素分析[J].新乡医学院学报,2020,37(6):563.[doi:10.7683/xxyxyxb.2020.06.014]
 DING Shaolong,KANG Bo,LI Zhijun.Influence factors of knee joint function rehabilitation after total knee arthroplasty in patients with knee osteoarthritis[J].Journal of Xinxiang Medical University,2020,37(10):563.[doi:10.7683/xxyxyxb.2020.06.014]
[8]石卓林,杨晓花,袁晓梅.特发性肺纤维化患者血清外泌体microRNA表达谱的变化及临床意义[J].新乡医学院学报,2022,39(5):481.[doi:10.7683/xxyxyxb.2022.05.016]
 SHI Zhuolin,YANG Xiaohua,YUAN Xiaomei.Changes and clinical significance of serum exosomal microRNA expression in patients with idiopathic pulmonary fibrosis[J].Journal of Xinxiang Medical University,2022,39(10):481.[doi:10.7683/xxyxyxb.2022.05.016]
[9]马胜利.膝骨关节炎患者血清炎性因子与血管生成相关因子的关系[J].新乡医学院学报,2016,33(7):626.[doi:10.7683/xxyxyxb.2016.07.021]
 MA Sheng-li.Relationship between serum inflammatory factors and angiogenesis related factors in patients with knee osteoarthritis[J].Journal of Xinxiang Medical University,2016,33(10):626.[doi:10.7683/xxyxyxb.2016.07.021]
[10]赵东方,尉志强,邢姝琴,等.巴戟天对骨关节炎小鼠软骨细胞自噬、凋亡的影响及机制[J].新乡医学院学报,2023,40(11):1001.[doi:10.7683/xxyxyxb.2023.11.001]
 ZHAO Dongfang,WEI Zhiqiang,XING Shuqin,et al.Effect and mechanism of morinda root on autophagy and apoptosis of chondrocytes in osteoarthritis mice[J].Journal of Xinxiang Medical University,2023,40(10):1001.[doi:10.7683/xxyxyxb.2023.11.001]
[11]陆智豪,陈立民,王颖赞,等.外泌体微RNA治疗骨关节炎研究进展[J].新乡医学院学报,2023,40(2):187.[doi:10.7683/xxyxyxb.2023.02.017]
 LU Zhihao,CHEN Limin,WANG Yingzan,et al.Research progress of exosomal microRNA in the treatment of osteoarthritis[J].Journal of Xinxiang Medical University,2023,40(10):187.[doi:10.7683/xxyxyxb.2023.02.017]

更新日期/Last Update: 2021-10-05