[1]张鑫众,孙倩倩,王锦姝,等.赖氨酸特异性组蛋白去甲基化酶4C在食管癌中的研究进展[J].新乡医学院学报,2021,38(10):977-981.[doi:10.7683/xxyxyxb.2021.10.016]
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赖氨酸特异性组蛋白去甲基化酶4C在食管癌中的研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年10
页码:
977-981
栏目:
综述
出版日期:
2021-10-05

文章信息/Info

作者:
张鑫众123孙倩倩1王锦姝123刘 刚123
(1.新乡医学院,河南 新乡 453003;2.河南省人民医院肿瘤内科,河南 郑州 450003;3.河南省人民医院临床单细胞生物医学中心,河南 郑州 450003)
关键词:
赖氨酸特异性组蛋白去甲基化酶4C食管癌靶向抑制剂
分类号:
R735.1
DOI:
10.7683/xxyxyxb.2021.10.016
文献标志码:
A
摘要:
食管癌是最具侵袭性的恶性肿瘤之一,具有高转移潜能、强异质性和晚期治疗的耐药性等特点。赖氨酸特异性组蛋白去甲基化酶4C(KDM4C)是组蛋白去甲基化酶家族成员之一,在多种肿瘤细胞中均表现为基因扩增和高表达,且在肿瘤进展中起重要作用,广泛参与肿瘤细胞的发生、发展、侵袭及转移等过程。本文主要对KDM4C在食管癌发生、发展中的作用及其靶向抑制剂的研究进展作一综述,以期为临床食管癌的早期诊断及靶向治疗药物的研发提供新思路。

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更新日期/Last Update: 2021-10-05