[1]马胜利.膝骨关节炎患者血清炎性因子与血管生成相关因子的关系[J].新乡医学院学报,2016,33(7):626-628.[doi:10.7683/xxyxyxb.2016.07.021]
　MA Sheng-li.Relationship between serum inflammatory factors and angiogenesis related factors in patients with knee osteoarthritis[J].Journal of Xinxiang Medical University,2016,33(7):626-628.[doi:10.7683/xxyxyxb.2016.07.021]
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膝骨关节炎患者血清炎性因子与血管生成相关因子的关系
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年7
页码:
626-628
栏目:
临床研究
出版日期:
2016-07-05

文章信息/Info

Title:
Relationship between serum inflammatory factors and angiogenesis related factors in patients with knee osteoarthritis
作者:
马胜利
（铜川矿务局中心医院骨外科，陕西　铜川　727000）
Author(s):
MA Sheng-li
（Department of Orthopaedics，the Central Hospital of Tongchuan Mining Bureau，Tongchuan 727000，Shaanxi Province，China）
关键词:
骨关节炎; 白细胞介素-2; 白细胞介素-6; 血管形成; 血管内皮生长因子; 碱性成纤维细胞生长因子; 血管生成素-1
Keywords:
osteoarthritis; interleukin-2; interleukin-6; angiopoiesis; vascular endothelial growth factor; basic fibroblast growth factor; angiogenin-1
分类号:
R684.3
DOI:
10.7683/xxyxyxb.2016.07.021
文献标志码:
A
摘要:
目的　探讨膝骨关节炎患者血清炎性因子与血管形成相关因子的关系。方法　选择2013年1月至2015年1月铜川矿务局中心医院收治的膝骨关节炎患者61例（膝骨关节炎组），另选择同期体检健康者25例作为正常对照组，检测2组受试者血清白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）及血管生成素-1（Ang-1）水平，并分析血清IL-2、IL-6与VEGF、bFGF、Ang-1的关系。结果　膝骨关节炎组患者血清IL-2、IL-6、VEGF、bFGF和Ang-1水平均显著高于正常对照组（P<0.05）。膝骨关节炎组Ⅲ级患者血清IL-2、IL-6、VEGF、bFGF和Ang-1水平均显著高于Ⅱ级患者（P<0.05），Ⅳ级患者血清IL-2、IL-6、VEGF、bFGF和Ang-1水平均显著高于Ⅱ、Ⅲ级患者（P<0.05）。Sperman相关性分析显示，膝骨关节炎患者血清IL-2与VEGF呈显著正相关 （r=0.398，P<0.05），与bFGF及Ang-1无显著相关性 （r=0.092、0.056，P>0.05）；膝骨关节炎患者血清IL-6与VEGF、bFGF呈显著正相关 （r=0.376、0.267，P<0.05），与Ang-1无显著相关性 （r=0.043，P>0.05）。结论　炎性因子可能参与了膝骨关节炎的发生和发展，且该过程与新生血管形成有密切关系。
Abstract:
Objective　To investigate the relationship between serum inflammatory factors and angiogenesis related factors in patients with knee osteoarthritis.Methods　Sixty-one cases of knee osteoarthritis（knee osteoarthritis group） in the Central Hospital of Tongchuan Mining Bureau were selected from January 2013 to January 2015.Twenty-five healthy subjects were selected as normal control group.The levels of serum interleukin-2（IL-2），interleukin-6（IL-6），vascular endothelial growth factor（VEGF），basic fibroblast growth factor（bFGF） and angiogenin-1（Ang-1） were detected.The relationship between serum IL-2，IL-6 and VEGF，bFGF，Ang-1 was analyzed.Results　The levels of serum IL-2，IL-6，VEGF，bFGF and Ang-1 in the patients with knee osteoarthritis were significantly higher than those in normal control group （P<0.05）.The levels of serum IL-2，IL-6，VEGF，bFGF and Ang-1 in the patients with knee osteoarthritis of grade Ⅲ were significantly higher than those in patients of gradeⅡ （P<0.05）.The levels of serum IL-2，IL-6，VEGF，bFGF and Ang-1 were significantly higher than those in patients of grade Ⅱ and Ⅲ （P<0.05）.Sperman correlation analysis showed that the serum IL-2 level was significantly positively correlated to VEGF（r=0.398，P<0.05），and there was no significant correlation between serum IL-2 and bFGF or Ang-1 in patients with knee osteoarthritis（r=0.092，0.056，P>0.05）.The serum IL-6 level was significantly positively correlated to VEGF and bFGF（r=0.376，0.267；P<0.05），and there was no significant correlation between serum IL-6 and Ang-1 in patients with knee osteoarthritis（r=0.043，P>0.05）.Conclusion　Inflammatory factors may be involved in the occurrence and development of knee osteoarthritis，and the process is closely related to neovascularization.

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更新日期/Last Update: 2016-07-05