[1]胡景岚.ω-3多不饱和脂肪酸和美沙拉嗪联合治疗对溃疡性结肠炎患者血清辅助性T细胞1及辅助性T细胞2细胞因子水平的影响[J].新乡医学院学报,2019,36(1):067-70.[doi:10.7683/xxyxyxb.2019.01.014]
　HU Jing-lan.Effect of ω-3 polyunsaturated fatty acid combined with mesalazine on the levels of serum helper T cell 1 and helper T cell 2 cytokines in patients with ulcerative colitis[J].Journal of Xinxiang Medical University,2019,36(1):067-70.[doi:10.7683/xxyxyxb.2019.01.014]
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ω-3多不饱和脂肪酸和美沙拉嗪联合治疗对溃疡性结肠炎患者血清辅助性T细胞1及辅助性T细胞2细胞因子水平的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年1
页码:
067-70
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Effect of ω-3 polyunsaturated fatty acid combined with mesalazine on the levels of serum helper T cell 1 and helper T cell 2 cytokines in patients with ulcerative colitis
作者:
胡景岚
（驻马店市中心医院消化内科，河南　驻马店　463000）
Author(s):
HU Jing-lan
（Department of Digestive System Diseases，Zhumadian Central Hospital，Zhumadian 463000，Henan Province，China）
关键词:
溃疡性结肠炎; ω-3多不饱和脂肪酸; 辅助性T细胞; 白细胞介素-2; γ-干扰素
Keywords:
ulcerative colitis; ω-3 polyunsaturated fatty acid; helper T cell; interleukin-2; interferon-γ
分类号:
R722.12
DOI:
10.7683/xxyxyxb.2019.01.014
文献标志码:
A
摘要:
目的　探讨ω-3多不饱和脂肪酸（ω-3PUFA）和美沙拉嗪联合治疗对溃疡性结肠炎患者血清辅助性T细胞1（Th1）及辅助性T细胞2（Th2）细胞因子的影响。方法　选择驻马店市中心医院2016年1月至2017年12月收治的78例溃疡性结肠炎患者为研究对象，按照治疗方法将患者分为观察组和对照组，每组39例。对照组患者给予美沙拉嗪治疗，观察组患者给予美沙拉嗪和ω-3PUFA联合治疗。分别于治疗前及治疗后采用酶联免疫吸附试验检测2组患者血清白细胞介素（IL）-2、IL-4、IL-10及γ-干扰素（IFN-γ）水平，采用改良Mayo评分评估结肠黏膜炎症反应程度，并评定临床疗效，观察不良反应发生情况。结果　治疗前2组患者血清IL-2、IL-4、IL-10及IFN-γ水平比较差异均无统计学意义（P>0.05）；2组患者治疗后血清IL-2水平与治疗前比较差异均无统计学意义（P>0.05）；2组患者治疗后血清IL-4水平显著低于治疗前，IL-10和IFN-γ水平显著高于治疗前（P<0.05）；治疗后，观察组患者血清IL-4水平显著低于对照组，IL-10和IFN-γ水平显著高于对照组（P<0.05）；治疗后2组患者血清IL-2水平比较差异无统计学意义（P>0.05）。治疗前2组患者改良Mayo评分比较差异无统计学意义（P>0.05）；2组患者治疗后改良Mayo评分显著低于治疗前（P<0.05）；治疗后观察组患者改良Mayo评分显著低于对照组（P<0.05）。观察组和对照组患者总有效率分别为94.9%（37/39）、79.5%（31/39），观察组患者总有效率高于对照组（χ2=7.515，P<0.05）。观察组和对照组患者不良反应发生率分别为10.3%（4/39）、20.5%（8/39），观察组患者不良反应发生率低于对照组（χ2=6.498，P<0.05）。结论　ω-3PUFA和美沙拉嗪联合治疗能有效改善溃疡性结肠炎患者血清中Th1和Th2细胞因子水平，减轻结肠黏膜的炎症反应，提高治疗效果，降低不良反应发生率。
Abstract:
Objective　To investigate the effect of ω-3 polyunsaturated fatty acid （ω-3PUFA） combined with mesalazine on the levels of serum helper T cell 1(Th1) and helper T cell 2(Th2) cytokines in patients with ulcerative colitis.Methods　A total of 78 patients with ulcerative colitis in Zhumadian Central Hospital from January 2016 to December 2017 were selected as the subjects.The patients were divided into observation group and control group according to the treatment method，39 cases in each group.The patients in the control group were treated with mesalazine，while the patients in the observation group were treated with mesalazine and ω-3PUFA.The levels of serum interleukin（IL）-2，IL-4，IL-10 and interferon-γ（IFN-γ） were detected by enzyme linked immunosorbent assay；and the degree of colonic mucosal inflammation was evaluated by modified Mayo score before and after treatment.The clinical effect was evaluated and the adverse reaction was observed.Results　There was no significant difference in the levels of serum IL-2，IL-4，IL-10 and IFN-γ between the two groups before treatment （P>0.05）.There was no significant difference in the level of serum IL-2 between the two groups before and after treatment （P>0.05）.Compared with before treatment，the level of serum IL-4 decreased significantly，and the levels of serum IL-10 and IFN-γ increased significantly after treatment in the two groups （P<0.05）.The level of serum IL-4 in the observation group was significantly lower than that in the control group，and the levels of serum IL-10 and IFN-γ in the observation group were significantly higher than those in the control group after treatment （P<0.05）.There was no significant difference in the level of serum IL-2 between the two groups after treatment （P>0.05）.There was no significant difference in the modified Mayo score between the two groups before treatment （P>0.05）.The modified Mayo score after treatment was significantly lower than that before treatment in the two groups （P<0.05）.The modified Mayo score in the observation group was significantly lower than that in the control group after treatment （P<0.05）.The total effective rate in the observation group and the control group was 94.9% （37/39） and 79.5% （31/39），respectively.The total effective rate in the observation group was higher than that in the control group （χ2=7.515，P<0.05）.The incidence of adverse reactions in the observation group and the control group was 10.3% （4/39） and 20.5% （8/39），respectively.The incidence of adverse reactions in the observation group was lower than that in the control group （χ2=6.498，P<0.05）.Conclusion　ω-3PUFA combined with mesalazine can effectively improve the levels of Th1 and Th2 cytokines，alleviate the inflammatory reaction of colonic mucosa，improve the therapeutic effect and reduce the incidence of adverse reactions in patients with ulcerative colitis.

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更新日期/Last Update: 2019-01-05