[1]许议丹,严振涛,王妍萱,等.妊娠期急性脂肪肝的发病机制、诊断及治疗研究进展[J].新乡医学院学报,2022,39(11):1087-1091.[doi:10.7683/xxyxyxb.2022.11.018]
　XU Yidan,YAN Zhentao,WANG Yanxuan,et al.Research progress on pathogenesis,diagnosis and treatment of acute fatty liver of pregnancy[J].Journal of Xinxiang Medical University,2022,39(11):1087-1091.[doi:10.7683/xxyxyxb.2022.11.018]
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妊娠期急性脂肪肝的发病机制、诊断及治疗研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年11
页码:
1087-1091
栏目:
综述
出版日期:
2022-11-05

文章信息/Info

Title:
Research progress on pathogenesis,diagnosis and treatment of acute fatty liver of pregnancy
作者:
许议丹1; 严振涛1; 王妍萱2; 赵志磊3; 王雪瑶2; 伍昭婷4; 马建军5
（1.新乡医学院第一临床学院，河南　新乡　453003；2.新乡医学院国际教育学院，河南　新乡　453003；3.新乡医学院基础医学院，河南　新乡　453003；4.汕头大学医学院附属肿瘤医院妇瘤科,广东　汕头　515041；5.新乡医学院人体解剖学实验室,河南　新乡　453003）
Author(s):
XU Yidan1; YAN Zhentao1; WANG Yanxuan2; ZHAO Zhilei3; WANG Xueyao2; WU Zhaoting4; MA Jianjun5
(1.The First Clinical College，Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.School of International Education，Xinxiang Medical University,Xinxiang 453003,China;3.School of Basic Medicine，Xinxiang Medical University,Xinxiang 453003,Henan Province,China;4.Department of Gynecologic Oncology,Cancer Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China;5.Laboratory of Human Anatomy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
妊娠期急性脂肪肝; 发病机制; 诊断; 治疗
Keywords:
acute fatty liver of pregnancy; pathogenesis; diagnosis; treatment
分类号:
R714.25
DOI:
10.7683/xxyxyxb.2022.11.018
文献标志码:
A
摘要:
妊娠期急性脂肪肝（AFLP）是一种常发生于妊娠晚期具有致死危险的急性肝脂肪变性疾病。AFLP临床表现主要为恶心呕吐、全身乏力、皮肤瘙痒、黄疸等非特异性症状，严重者会导致凝血功能障碍、肝衰竭、多器官功能衰竭、早产、死胎等不良结局。AFLP的临床表现缺乏特异性，且其部分临床生物化学特征与HELLP综合征或子痫前期等其他妊娠期疾病相似，因此早期诊断比较困难。目前，准确诊断、及时分娩和积极采取支持治疗是AFLP的基本处理原则。本文综述了AFLP的发病机制、诊断和治疗措施，以期为AFLP的临床治疗及预后改善提供参考。
Abstract:
Acute fatty liver of pregnancy (AFLP) is an acute steatosis disease that often occurs in late pregnancy and has the risk of death.The clinical manifestations of AFLP are mainly non-specific symptoms such as nausea and vomiting,general fatigue,skin itching,jaundice,etc.In severe cases,it will lead to coagulation dysfunction,liver failure,multiple organ failure,premature delivery,stillbirth and other adverse outcomes.The clinical manifestations of AFLP are lack of specificity,and some of its clinical biochemical characteristics are similar to HELLP syndrome or preeclampsia and other pregnancy diseases,so early diagnosis is difficult.At present,accurate diagnosis,timely delivery and active supportive treatment are the basic treatment principles of AFLP.This article reviews the pathogenesis,diagnosis and treatment of AFLP in order to provide reference for clinical treatment and improvement of prognosis of AFLP.

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更新日期/Last Update: 2022-11-05