[1]刘晓斌,李　民,黄卫东.血清肿瘤坏死因子-α和胶质纤维酸性蛋白水平与脑胶质瘤恶性程度及患者预后的相关性[J].新乡医学院学报,2017,34(12):1097-1100.[doi:10.7683/xxyxyxb.2017.12.013]
　LIU Xiao-bin,LI Min,HUANG Wei-dong.Correlation between the levels of serum tumor necrosis factor-α，glial fibrillary acidic protein and the malignant degree and prognosis of patients with brain glioma[J].Journal of Xinxiang Medical University,2017,34(12):1097-1100.[doi:10.7683/xxyxyxb.2017.12.013]
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血清肿瘤坏死因子-α和胶质纤维酸性蛋白水平与脑胶质瘤恶性程度及患者预后的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年12
页码:
1097-1100
栏目:
临床研究
出版日期:
2017-12-05

文章信息/Info

Title:
Correlation between the levels of serum tumor necrosis factor-α，glial fibrillary acidic protein and the malignant degree and prognosis of patients with brain glioma
作者:
刘晓斌; 李　民; 黄卫东
（陕西省人民医院神经外科，陕西　西安　710068）
Author(s):
LIU Xiao-bin; LI Min; HUANG Wei-dong
（Department of Neurosurgery，Shaanxi Provincial People′s Hospital，Xi′an 710068，Shaanxi Province，China）
关键词:
脑胶质瘤; 肿瘤坏死因子-α; 胶质纤维酸性蛋白; 预后
Keywords:
brain glioma; tumor necrosis factor-α; glial fibrillary acidic protein; prognosis
分类号:
R739.41
DOI:
10.7683/xxyxyxb.2017.12.013
文献标志码:
A
摘要:
目的　探讨血清肿瘤坏死因子-α（TNF-α）和胶质纤维酸性蛋白（GFAP）水平与脑胶质瘤恶性程度及患者预后的相关性。方法　选取2013年3月至2015年9月陕西省人民医院收治的脑胶质瘤患者90例，依据恶性程度病理学分级将患者分为低度恶性组43例和高度恶性组47例；选择同期体检健康志愿者52例作为对照组。脑胶质瘤患者分别于治疗前、术后第14天、放射治疗和化学治疗后第1天采集晨起空腹静脉血5 mL，对照组受试者于体检当日采集晨起空腹静脉血5 mL，采用酶联免疫吸附法测定血清TNF-α水平，双抗体夹心法测定血清GFAP水平。结果　治疗前，低度恶性组和高度恶性组患者血清TNF-α、GFAP水平显著高于对照组（P<0.05），高度恶性组患者血清TNF-α、GFAP水平显著低于低度恶性组（P<0.05）。低度恶性组患者术后第14天及放射治疗和化学治疗后血清TNF-α、GFAP水平显著低于治疗前（P<0.05），放射治疗和化学治疗后血清TNF-α、GFAP水平显著低于术后第14天（P<0.05）。高度恶性组患者术后第14天血清TNF-α水平显著低于治疗前（P<0.05），但GFAP水平与治疗前比较差异无统计学意义（P>0.05）；高度恶性组患者放射治疗和化学治疗后血清TNF-α、GFAP水平显著低于治疗前和术后第14天（P<0.05）。治疗后，完全缓解患者血清TNF-α及GFAP水平显著低于部分缓解、疾病稳定和疾病进展患者（P<0.05），部分缓解患者血清TNF-α及GFAP水平显著低于疾病稳定和疾病进展患者（P<0.05），疾病稳定患者血清TNF-α及GFAP水平显著低于疾病进展患者（P<0.05）。结论　脑胶质瘤患者血清TNF-α和GFAP水平与肿瘤恶性程度、治疗效果有一定的相关性，可以作为临床评估脑胶质瘤恶性程度、治疗效果及预后的生物学标志物。
Abstract:
Objective　To investigate the correlation between the levels of serum tumor necrosis factor-α（TNF-α），glial fibrillary acidic protein（GFAP） and the malignant degree and prognosis of patients with brain glioma.Methods　A total of 90 patients with brain glioma were collected from March 2013 to September 2015 in Shaanxi Provincial People′s Hospital.The patients were divided into low malignant degree group （n=43） and high malignant degree group （n=47） according to the pathological grade of malignant degree.Fifty-two healthy volunteers were selected as control group at the same period.The fasting venous blood 5 mL of the patients with brain glioma was collected at the time points of pretherapy，the 14th day after operation，the first day after radiotherapy and chemotherapy.The fasting venous blood 5 mL was collected on the day of physical examination in the control group.The level of serum TNF-α was detected by enzyme-linked immunosorbent assay，and the level of serum GFAP was measured by double antibody sandwich method.Results　The levels of serum TNF-α and GFAP in the low malignant degree group and high malignant degree group were significantly higher than those in the control group （P<0.05），and the levels of serum TNF-α and GFAP in the high malignant degree group were significantly lower than those in the low malignant degree group before treatment （P<0.05）.The levels of serum TNF-α and GFAP at the time points on the 14th day after operation and after radiotherapy and chemotherapy were significantly lower than those before treatment （P<0.05）；the levels of serum TNF-α and GFAP after radiotherapy and chemotherapy were significantly lower than those on the 14th day after operation in the low malignant degree group （P<0.05）.The level of serum TNF-α on the 14th day after operation was significantly lower than that before treatment in the high malignant degree group （P<0.05）.There was no significant difference in serum GFAP level between the 14th day after operation and before treatment in the high malignant degree group （P>0.05）.The levels of serum TNF-α and GFAP after radiotherapy and chemotherapy were significantly lower than those before treatment and the 14th day after operation in the high malignant degree group （P<0.05）.The levels of serum TNF-α and GFAP in the patients with complete remission were significantly lower than those in the patients with partial remission，stable disease and progressive disease after treatment （P<0.05）.The levels of serum TNF-α and GFAP in the patients with partial remission were significantly lower than those in the patients with stable disease and progressive disease after treatment （P<0.05）.The levels of serum TNF-α and GFAP in the patients with stable disease were significantly lower than those in the patients with progressive disease after treatment （P<0.05）.Conclusion　The levels of serum TNF-α and GFAP are correlated with the malignant degree and the therapeutic effect in patients with brain glioma.It can be used as a biological marker to evaluate the malignant degree，therapeutic effect and prognosis of brain glioma.

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更新日期/Last Update: 2017-12-05