[1]屈亚云,武莉芳,张秀敏,等.依达拉奉对肺癌胸腔镜手术中单肺通气相关肺损伤的保护作用[J].新乡医学院学报,2016,33(12):1054-1056.[doi:10.7683/xxyxyxb.2016.12.010]
　QU Ya-yun,WU Li-fang,ZHANG Xiu-min,et al.Protective effect of edaravone on injury of lungs induced by one lung ventilation in lung cancer patients undergoing thorascopic surgery[J].Journal of Xinxiang Medical University,2016,33(12):1054-1056.[doi:10.7683/xxyxyxb.2016.12.010]
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依达拉奉对肺癌胸腔镜手术中单肺通气相关肺损伤的保护作用
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年12
页码:
1054-1056
栏目:
临床研究
出版日期:
2016-12-05

文章信息/Info

Title:
Protective effect of edaravone on injury of lungs induced by one lung ventilation in lung cancer patients undergoing thorascopic surgery
作者:
屈亚云; 武莉芳; 张秀敏; 罗磊萍; 朱红霞; 苏心镜
（河北北方学院附属第二医院麻醉科，河北　张家口　075100）
Author(s):
QU Ya-yun; WU Li-fang; ZHANG Xiu-min; LUO Lei-ping; ZHU Hong-xia; SU Xin-jing
（Department of Anesthesiology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,Hebei Province,China)
关键词:
依达拉奉; 单肺通气; 水通道蛋白; 肿瘤坏死因子-α; 白细胞介素-8; 胸腔镜手术; 肺损伤; 肺癌
Keywords:
edaravone; one lung ventilation; aquaporin; tumor necrosis factor-α; interleukin-8; thorascopic surgery; lung injury; lung cancer
分类号:
R734.2
DOI:
10.7683/xxyxyxb.2016.12.010
文献标志码:
A
摘要:
目的　观察依达拉奉在肺癌胸腔镜手术中单肺通气时相关肺损伤的保护作用。方法　选择2013年1月至2015年12月于河北北方学院附属第二医院择期行胸腔镜肺叶切除手术的肺癌患者60例，随机将其分为对照组和依达拉奉组，每组30例。依达拉奉组患者于手术前30 min开始静脉滴注依达拉奉30 mg（溶于100 mL生理盐水），30 min内滴注完毕，对照组以同样方式静脉滴注100 mL生理盐水。2组患者分别于切皮前和单肺通气结束时取肘静脉血样，检测血清肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）水平；于开胸单肺通气开始时、肺叶离断时取肿瘤边缘正常肺组织，测定肺水通道蛋白1（AQP1）、肺水通道蛋白4（AQP4）表达，并对2组患者检测结果进行比较。结果　单肺通气结束时2组患者血清TNF-α、IL-8水平较肺通气开始时明显升高（P<0.05）；依达拉奉组患者单肺通气结束时血清TNF-α、IL-8水平较对照组明显下降（P<0.05）。与开胸单肺通气时比较，肺叶切除时2组患者肺组织AQP1和AQP4表达明显增高（P<0.05）；与对照组比较，依达拉奉组患者肺叶切除时肺组织AQP1和AQP4表达明显降低（P<0.05）。结论　依达拉奉预先给药可降低肺癌胸腔镜肺叶切除术单肺通气时TNF-α、IL-8水平，抑制AQP1、AQP4的表达。
Abstract:
Objective　To observe the protective effect of edaravone on injury of lungs induced by one lung ventilation in lung cancer patients undergoing thorascopic surgery.Methods　Sixty lung cancer patients who scheduled for thorascopic pulmonary lobectomy surgery in the Second Affiliated Hospital of Hebei North University from January 2013 to December 2015 were selected and randomly divided into edaravone group and control group,with 30 patients in each group.The patients in edaravone group received intravenous injection of edaravone 30 mg(dissolution in normal saline 100 mL)within 30 min before surgery;the patients in control group was administered normal saline 100 mL in the same manner.Ulnar venous blood samples were taken from all patients before skin incision and at the end of one lung ventilation for detecting the serum levels of tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8).The normal lung tissues of tumor margin were taken when the one lung ventilation was started and the lung lobe was resected to detect the expression of aquaporin 1(AQP1)and AQP4;then the results of the patients were compared between the two groups.Results　The levels of TNF-α and IL-8 of patiens in the two groups at the end of one lung ventilation were significantly higher than onset of lung ventilation（P<0.05）.The levels of TNF-α and IL-8 of patiens in the edaravone group were significantly lower than those in the control group at the end of one lung ventilation（P<0.05）.The expression of AQP1 and AQP4 of patients in the two groups at the time point of the lung lobe was resected were significantly higher than at the time point of one lung ventilation(P<0.05).Compared with control group,the expression of AQP1 and AQP4 of patients in edaravone group were lower at the time point of the lung lobe was resected（P<0.05）.Conclusion　Edaravone can reduce the levels of TNF-α,IL-8 and inhibit the expression of AQP1,AQP4 in lung cancer patients undergoing thorascopic pulmonary lobectomy surgery.

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更新日期/Last Update: 2016-12-05