[1]朱海松,卢学仁.坦索罗辛联合远期外科手术治疗局限性前列腺癌术后排尿困难及尿潴留的临床效果观察[J].新乡医学院学报,2016,33(6):511-514.[doi:10.7683/xxyxyxb.2016.06.018]
　ZHU Hai-song,LU Xue-ren.Clinical effect of tamsulosin combined with long-term surgical treatment for postoperative dysuria and urinary retention in patients with localized prostate cancer[J].Journal of Xinxiang Medical University,2016,33(6):511-514.[doi:10.7683/xxyxyxb.2016.06.018]
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坦索罗辛联合远期外科手术治疗局限性前列腺癌术后排尿困难及尿潴留的临床效果观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年6
页码:
511-514
栏目:
临床研究
出版日期:
2016-06-05

文章信息/Info

Title:
Clinical effect of tamsulosin combined with long-term surgical treatment for postoperative dysuria and urinary retention in patients with localized prostate cancer
作者:
朱海松; 卢学仁
（驻马店市中心医院泌尿外一科，河南　驻马店　463000）
Author(s):
ZHU Hai-song; LU Xue-ren
（Department of Urology，the Central Hospital of Zhumadian City，Zhumadian 463000，Henan Province，China）
关键词:
前列腺癌; 局限性; 排尿困难; 尿潴留; 保守治疗; 手术治疗
Keywords:
prostate cancer; localized; dysuria; urinary retention; conservative treatment; surgical treatment
分类号:
R697.3
DOI:
10.7683/xxyxyxb.2016.06.018
文献标志码:
A
摘要:
目的　评价坦索罗辛联合远期外科手术治疗局限性前列腺癌术后排尿困难及尿潴留的临床效果。方法　选择在驻马店市中心医院泌尿外科行125I粒子植入术的局限性前列腺癌患者332例，其中术后患者存在明显排尿不畅及尿潴留的患者49例，全部患者针对其是否同意接受远期局限性经尿道前列腺切除术分为对照组（20例，不同意接受）和观察组（29例，同意接受），全部患者均于125I粒子植入术后第2天采取口服0.2 mg坦索罗辛，每晚1次。并于留置尿管6个月后，观察组患者行局限性经尿道前列腺切除术（TURP），对观察组患者术中情况和术后并发症进行观察，同时，对2组患者在观察组手术前后各个时间点（术前及尿管拔除后第2天及术后1、3、6个月）的国际前列腺症状评分（IPSS）、平均尿流率、残余尿量（PVR）及生存质量（QOL）评分进行比较分析。结果　观察组患者手术过程顺利，平均手术时间（52.1±9.0）min。观察组患者拔管后第2天及术后1、3、6个月的IPSS评分、PVR及QOL评分均显著低于术前（P<0.05），而平均尿流率显著高于术前（P<0.05）。观察组患者在拔管后第2天及术后1、3、6个月的IPSS评分、PVR及QOL评分均显著低于对照组（P<0.05），且平均尿流率显著高于对照组（P<0.05）。结论　坦索罗辛联合远期外科手术能够显著改善局限性前列腺癌患者125I粒子植入术后的排尿困难状况，提高患者生存质量。
Abstract:
Objective　To study the clinical effects of tamsulosin combined with long-term surgical treatment for postoperative dysuria and urinary retention in patients with localized prostate cancer.Methods　Three hundred and thirty-two patients with localized prostate cancer who were treated with 125I seeds implantation in the Department of Urology in the Central Hospital of Zhumadian City were selected，there were 49 cases of patients with obvious postoperative dysuria and urinary retention.All patients were divided into control group （20 cases，not agreed to accept） and observation group （29 patients，agreed to accept） according to their consent to accept the long-term limitations of transurethral resection of the prostate or not.All the patients received orally 0.2 mg tamsulosin on the second day after 125I implantation，once every night.After six months of indwelling catheter，patients in the observation group were treated with limited transurethral resection of prostate （TURP）.The intraoperative condition and postoperative complications were observed in the observation group.International prostate symptom score（IPSS），the average urinary flow rate，postvoid residual（PVR） and quality of life （QOL） scores in the two groups at each time point before and after surgery （before operation，two days after the removal of the catheter，1 month，3 and 6 months after operation） were compared and analyzed.Results　Twenty-nine cases in observation group were successfully operated，the average operation time was （52.1±9.0） min.Two days after the removal of the catheter，1 month，3 and 6 months after operation，IPSS score，PVR and QOL scores were significantly lower than the preoperative indexes （P<0.05），while the mean urinary flow rate was significantly higher than preoperative in observation group （P<0.05）.Two days after the removal of the catheter，1 month，3 and 6 months after operation，IPSS score，PVR and QOL scores in observation group were significantly lower than those in the control group（P<0.05），and mean urinary flow rate was significantly higher than that in the control group （P<0.05）.Conclusion　Tamsulosin combined with long-term surgery can significantly improve the postoperative dysuria and urinary retention in patients with localized prostate cancer，and greatly improve the quality of life of patients.

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更新日期/Last Update: 2016-06-05