[1]金阳,刘馨洁,黄嘉琦,等.母体免疫激活导致子代精神分裂症的机制研究进展[J].新乡医学院学报,2023,40(11):1087-1090.[doi:10.7683/xxyxyxb.2023.11.016]
　JIN Yang,LIU Xinjie,HUANG Jiaqi,et al.Research progress on the mechanism of schizophrenia in offspring induced by maternal immune activation[J].Journal of Xinxiang Medical University,2023,40(11):1087-1090.[doi:10.7683/xxyxyxb.2023.11.016]
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母体免疫激活导致子代精神分裂症的机制研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年11
页码:
1087-1090
栏目:
综述
出版日期:
2023-11-05

文章信息/Info

Title:
Research progress on the mechanism of schizophrenia in offspring induced by maternal immune activation
作者:
金阳1; 刘馨洁1; 黄嘉琦1; 王钰冰1; 陈琦1; 宋盟2; 吕路线2
（1.新乡医学院第二临床学院，河南　新乡　453003；2.新乡医学院第二附属医院河南省生物精神病学重点实验室，河南　新乡　453002）
Author(s):
JIN Yang1; LIU Xinjie1; HUANG Jiaqi1; WANG Yubing1; CHEN Qi1; SONG Meng2; LYU Luxian2
(1.The Second Clinical College,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.Henan Key Laboratory of Biological Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)
关键词:
母体免疫激活; 精神分裂症; 小胶质细胞; 神经递质紊乱; 免疫调节
Keywords:
maternal immune activation; schizophrenia; microglia; neurotransmitter disorder; immunoregulation
分类号:
R794.3
DOI:
10.7683/xxyxyxb.2023.11.016
文献标志码:
A
摘要:
精神分裂症（SCZ）是一种重型精神疾病，20世纪末我国SCZ的发病率高达5.69%。虽然，现有抗精神病药物对SCZ患者的临床症状具有一定的改善作用，但仍有约1/3的患者对药物的反应不佳，SCZ已成为全球性公共卫生问题。SCZ病因复杂，其发病机制尚不明确。研究发现，母体免疫激活（MIA）可引起子代中枢神经免疫系统、神经递质系统、突触可塑性以及脑-肠轴功能等异常改变，从而增加子代患SCZ的风险。基于此，本文就MIA导致子代患SCZ的临床证据、病理改变和相关机制研究进行综述。
Abstract:
Schizophrenia (SCZ) is a serious neuropsychiatric disorder,with an incidence of 5.69% in China at the end of the 20th century.Although the antipsychotic drugs have a certain improvement effect on the clinical symptoms of SCZ patients,but about 1/3 of patients still have poor response to the drugs,SCZ has become a global public health problem.The etiology of SCZ is complex,and its pathogenesis is still unclear.Maternal immune activation (MIA) can cause abnormal changes of central nervous immune system,neurotransmitter system,synaptic plasticity and brain-gut axis function in offspring,thus increasing the risk of SCZ in offspring.Based on this,this article reviews the clinical evidence,pathological changes and related mechanisms of SCZ in offspring induced by MIA.

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更新日期/Last Update: 2023-11-05