[1]兰宝恒,吴泽青.柴胡的化学成分及药理作用研究进展[J].新乡医学院学报,2023,40(2):174-180.[doi:10.7683/xxyxyxb.2023.02.015]
　LAN Baoheng,WU Zeqing.Research progress on chemical constituents and pharmacological action of Bupleurum[J].Journal of Xinxiang Medical University,2023,40(2):174-180.[doi:10.7683/xxyxyxb.2023.02.015]
点击复制

柴胡的化学成分及药理作用研究进展
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年2期
页码:
174-180
栏目:
综述
出版日期:
2023-02-05

文章信息/Info

Title:
Research progress on chemical constituents and pharmacological action of Bupleurum
作者:
兰宝恒; 吴泽青
（新乡医学院药学院，河南　新乡　453003）
Author(s):
LAN Baoheng; WU Zeqing
(College of Pharmacy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
柴胡; 化学成分; 药理作用
Keywords:
Bupleurum; chemical constituents; pharmacological action
分类号:
R285
DOI:
10.7683/xxyxyxb.2023.02.015
文献标志码:
A
摘要:
柴胡临床应用广泛，化学成分复杂，其中皂苷类、黄酮类、挥发油类、多糖类、香豆素类为主要活性成分，具有抗癌、抗抑郁、抗炎、抗氧化、保护心脏、保护肝脏、保护肾脏、镇痛、抗纤维化、抗病毒等作用。本文对柴胡化学成分及药理作用研究进展进行综述，以期为柴胡的临床合理应用及资源开发奠定基础。
Abstract:
Bupleurum has a wide range of clinical applications,and its chemical constituents is complex,the saponins,flavonoids,volatile oils,polysa-ccharides and coumarins are the main active components of Bupleurum.It has the effects of anti-cancer,anti-depression,anti-inflammation,anti-oxidation,protecting heart,protecting liver,protecting kidney,analgesia,anti-fibrosis,anti-virus,and so on.In this paper,the research progress in the chemical components and pharmacological effects of Bupleurum was reviewed in order to lay a foundation for the rational clinical application and resource development of Bupleurum.

参考文献/References:

［1］国家药典委员会.中华人民共和国药典:一部［S］.北京:中国医药科技出版社,2020:280.NATIONAL PHARMACOPOEIA COMMITTEE.People′s Republic of China Pharmacopoeia:a ［S］.Beijing:China Medical Science and Technology Press,2020:280.
［2］　冯建有,高晓霞,秦雪梅.探讨柴胡差异、临床应用和毒副作用［J］.中药材,2019,42(9):2200-2205.FENG J Y,GAO X X,QIN X M.To explore the difference,clinical application and side effects of Bupleurum［J］.J Chin Med Mater,2019,42(9):2200-2205.
［3］　孙蓉,王丽,任海勇,等.基原对柴胡急性毒性和皂苷类物质含量影响的实验研究［J］.中国药物警戒,2009,6(12):705-708.SUN R,WANG L,REN H Y,et al.Experimental research of influences on acute toxicity and saponins substances caused by different original of Bupleurum chinense ［J］.Chin J Pharmacov,2009,6(12):705-708.
［4］　肖炳坤,骆传环,黄荣清,等.气相色谱法测定柴胡多糖的组分［J］.生命科学仪器,2005,3(3):34-35.XIAO B K,LUO C H,HUANG R Q,et al.Component analysis of Bupleurum polysaccharides by gas chromatography［J］.Life Sci Instrum,2005,3(3):34-35.
［5］　张亮,胡海宝,黄朝瑜,等.南柴胡多糖分离与组成的初步研究［J］.中草药,2000,31(9):647-648.ZHANG L,HU H B,HUANG C Y,et al.Studies on the composition of polysaccharide from Bupleurum scorzonerifolium ［J］.Chin Trad Herbal Drugs,2000,31(9):647-648.
［6］　张峰,方媛,周玉枝,等.UPLC-PDA同时测定柴胡中8种多炔类化合物的含量［J］.中国中药杂志,2017,42(9):1704-1710.ZHANG F,FANG Y,ZHOU Y Z,et al.Simultaneous determination of 8 polyyne compounds in Bupleurum by UPLC-PDA［J］.China J Chin Mater Med,2017,42(9):1704-1710.
［7］　肖蓉,张志斐,韩学静,等.不同产地柴胡药材GC-MS指纹图谱研究［J］.中草药,2006,37(8):1248-1252.XIAO R,ZHANG Z F,HAN X J,et al.GC-MS fingerprints of Radix Bupleuri from various habitats［J］.Chin Trad Herbal Drugs,2006,37(8):1248-1252.
［8］　刘艳,张振朋,肖宗雨,等.柴胡地上部分的化学成分研究［J］.中药材,2021,44(7):1620-1625.LIU Y,ZHANG Z P,XIAO Z Y,et al.Chemical constituents from the aerial parts of Bupleurum chinense［J］.J Chin Med Mater,2021,44(7):1620-1625.
［9］　孙健,张立富,范斌,等.柴胡皂苷类化学成分的LC-MS分析［J］.中国药物警戒,2012,9(12):725-727.SUN J,ZHANG L F,FAN B,et al.LC-MS Analysis of saponins in Bupleurum chinense DC.［J］.Chin J Pharmacov,2012,9(12):725-727.
［10］　YANG Y Y,TANG Y Z,FAN C L,et al.Identification and determination of the saikosaponins in Radix bupleuri by accelerated solvent extraction combined with rapid-resolution LC-MS［J］.J Sep Sci,2010,33(13):1933-1945.
［11］　LI D Q,WU J,LIU L Y,et al.Cytotoxic triterpenoid glycosides (saikosaponins) from the roots of Bupleurum chinense［J］.Bioorg Med Chem Lett,2015,25(18):3887-3892.
［12］　YANG F,DONG X,YIN X,et al.Radix Bupleuri:a review of traditional uses,botany,phytochemistry,pharmacology,and toxicology［J］.Biomed Res Int,2017,2017:7597596.
［13］　乔亚荣.柴胡中皂苷类成分的药代动力学及组织分布研究［D］.山西:山西大学,2016.QIAO Y R.Study on pharmacokinetics and tissue distribution of saponins in Bupleurum chinense［D］.Shanxi:Shanxi University,2016.
［14］　郭敏娜,刘素香,赵艳敏,等.基于HPLC-Q-TOF-MS技术的柴胡化学成分分析［J］.中草药,2016,47(12):2044-2052.GUO M N,LIU S X,ZHAO Y M,et al.Analysis on chemical constituents in Bupleuri Radix by HPLC-Q-TOF-MS［J］.Chin Trad Herbal Drugs,2016,47(12):2044-2052.
［15］　EBATA N,NAKAJIMA K,HAYASHI K,et al.Saponins from the root of Bupleurumfalcatum［J］.Phytochemistry,1996,41(3):895-901.
［16］　刘永春,丛培臣.柴胡的化学成分及药理作用研究概况［J］.黑龙江医药,2006,19(3):216-218.LIU Y C,CONG P C.General situation of studies on chemical constituents and pharmacological effects of Bupleurum［J］.Heilongjiang Med J,2006,19(3):216-218.
［17］　肖宗雨,刘艳,孙延平,等.柴胡地上部分黄酮类化学成分研究［J］.中药材,2020,43(11):2679-2683.XIAO Z Y,LIU Y,SUN Y P,et al.Chemical constituents of flavonoids from the aerial parts of Bupleurum chinense［J］.J Chin Med Mater,2020,43(11):2679-2683.
［18］　王宁,王金辉,李铣.北柴胡地上部分化学成分的分离与鉴定［J］.沈阳药科大学学报,2005,22(5):342-344,370.WANG N,WANG J H,LI M.Chemical constituents of the aerial part of Bupleurum chinense DC.［J］.J Shenyang Pharm Univ,2005,22(5):342-344,370.
［19］　沃源,姚琳,孙世伟.北柴胡化学成分的研究进展［J］.黑龙江医药,2011,24(2):215-217.WO Y,YAO L,SUN S W.Progress of chemical constituents of Bupleurum chinense［J］.Heilongjiang Med J,2011,24(2):215-217.
［20］　陈亚双,孙世伟.柴胡的化学成分及药理作用研究进展［J］.黑龙江医药,2014,27(3):630-633.CHEN Y S,SUN S W.Research progress on chemical constituents an pharmacological action of Bupleurum［J］.Heilongjiang Med J,2014,27(3):630-633.
［21］　MENG J,CHEN X,YANG W,et al.Gas chromatography-mass spectrometry analysis of essential oils from five parts of Chaihu (Radix Bupleuri Chinensis)［J］.J Tradit Chin Med,2014,34(6):741-748.
［22］　霍梦逸,刘新,林於,等.柴胡挥发油中有效解热成分的研究［J］.药物分析杂志,2013,33(7):1202-1209.HUO M Y,LIU X,LIN Y,et al.Study on antipyretic active ingredients in Bupleurum chinense volatile oil［J］.Chin J Pharm Anal,2013,33(7):1202-1209.
［23］　施铮,陈仁寿,陈勇.不同方法提取的柴胡挥发油化学成分比较［J］.南京中医药大学学报,2015,31(6):576-578.SHI Z,CHEN R S,CHEN Y.Study on the chemical composition of the essential oil extracted from Bupleurum chinense by different methods［J］.J Nanjing Univ Trad Chin Med,2015,31(6):576-578.
［24］　夏召弟,刘霞.北柴胡化学成分及质量控制方法研究进展［J］.中国现代中药,2021,23(5):940-949.XIA Z D,LIU X.Research progress on chemical constituents and quality control methods of Bupleurum chinense［J］.Mod Chin Med,2021,23(5):940-949.
［25］　SHI S,CHANG M,LIU H,et al.The structural characteristics of an acidic water-soluble polysaccharide from Bupleurum chinense DC and its in vivo anti-tumor activity on H22 tumor-bearing mice［J］.Polymers,2022,14(6):1119.
［26］　李岱,张静,孙润广.超声波处理对柴胡多糖提取率、微观形貌特征及生物活性的影响［J］.生物加工过程,2009,7(2):29-34.LI D,ZHANG J,SUN R G.Effect of ultrasound on extraction yields,morphology,and biological activity of polysaccharide from Bulpeurum［J］.Chin J Bioprocess Engineer,2009,7(2):29-34.
［27］　方媛,张峰,刘佳丽,等.柴胡中多炔类化合物的分离鉴定及定量测定［J］.中草药,2015,46(16):2365-2370.FANG Y,ZHANG F,LIU J L,et al.Isolation and quantitative determination of polyacetylenes in Bupleuri Radix［J］.Chin Trad Herbal Drugs,2015,46(16):2365-2370.
［28］　方媛.柴胡石油醚部位的化学成分与抗抑郁活性研究［D］.山西:山西大学,2016.FANG Y.Studies on the chemical constituents and anti-depressant activity of the petroleum ether fraction of Radix［D］.Shanxi:Shanxi University,2016.
［29］　邓辉.北柴胡化学成分与药理作用？［J］.家庭生活指南,2021,37(11):177-179.DENG H.Chemical constituents and pharmacological action of Bupleurum chinense? ［J］.Family Life Guide,2021,37(11):177-179.
［30］　金国泰,李博,王树荣.柴胡解热的物质基础、药效及机制研究［J］.西部中医药,2014,27(2):20-22.JIN G T,LI B,WANG S R.Research on the mechanism,the effects and material foundation of ChaiHu in relieving fever［J］.Western J Trad Chin Med,2014,27(2):20-22.
［31］　巫丹.柴胡与赤芍、醋柴胡与白芍配伍前后药效学比较［J］.亚太传统医药,2017,13(1):18-19.WU D.Comparison of pharmacodynamics between Bupleurum and Radix Paeoniae Rubra,Bupleurum vinegar and Radix Paeoniae Alba before and after compatibility［J］.Asia-Pac Trad Med,2017,13 (1):18-19.
［32］　谈英,杨晓娟,韩晓妮,等.基于网络药理学的柴胡镇痛作用机制初探［J］.中国药学杂志,2019,54(2):98-104.TAN Y,YANG X J,HAN X N,et al.Investigation of analgesic mechanisms of Bupleuri Radix with network pharmacology［J］.Chin Pharm J,2019,54(2):98-104.
［33］　JIANG H,YANG L,HOU A,et al.Botany,traditional uses,phytochemistry,analytical methods,processing,pharmacology and pharmacokinetics of Bupleuri Radix:a systematic review［J］.Biomed Pharmacother,2020,131:110679.
［34］　颜美玲,杨柳,侯阿娇,等.柴胡化学成分及药理作用研究进展［J］.中医药信息,2018,35(5):103-109.YAN M L,YANG L,HOU A J,et al.Research progress on chemical composition and pharmacological effect of Bupleurum chinense［J］.Inform Trad Chin Med,2018,35(5):103-109.
［35］　倪新强,曹美群,吴正治,等.柴胡疏肝散抗抑郁的临床应用、药理作用及化学成分研究进展［J］.辽宁中医杂志,2017,44(11):2434-2438.NI X Q,CAO M Q,WU Z Z,et al.Research progress on clinical application,pharmacological activities and chemical ingredients of Chaihu Shugan Powder in treating depression［J］.Liaoning J Trad Chin Med,2017,44(11):2434-2438.
［36］　周瑾,黄菲,吴晓俊.柴胡疏肝散抗抑郁化学成分和药理作用研究进展［J］.中药药理与临床,2019,35(2):174-179.ZHOU J,HUANG F,WU X J.Research progress on anti-depressant chemical constituents and pharmacological effects of Chaihu Shugan Powder［J］.Pharmac Clin Chin Mater Medica,2019,35(2):174-179.
［37］　郭旭彤,安继东,梅建强.柴胡皂苷A对抑郁症大鼠Treg和Th17免疫平衡的影响［J］.海南医学院学报,2020,26(22):1686-1690.GUO X T,AN J D,MEI J Q.Effect of saikosaponin A on Treg and Th17 immune balance in depressive rats［J］.J Hainan Med Univ,2020,26(22):1686-1690.
［38］　张云,高博,许海军.柴胡皂苷D基于PI3K/AKT/FoxO1调节神经炎症发挥抗抑郁作用［J］.实用药物与临床,2021,24(5):395-399.ZHANG Y,GAO B,XU H J.Saikosaponin D regulates neuroinflammation and exerts antidepressant effect through PI3K/AKT/FoxO1 pathway［J］.Pract Pharm Clin Rem,2021,24(5):395-399.
［39］　张胜,张尧,李彪,等.山奈酚对CUMS抑郁模型大鼠海马神经元过度自噬和氧化应激损伤的保护作用［J］.中国免疫学杂志,2019,35(2):146-150,155.ZHANG S,ZHANG Y,LI B,et al.Protective effects of kaempferol on autophagy-and oxidative stress-mediated injury of hippocampal neuron in CUMS-induced depression model rats［J］.Chin J Immun,2019,35(2):146-150,155.
［40］　吴丹,高耀,向欢,等.基于网络药理学的柴胡抗抑郁作用机制研究［J］.药学学报,2018,53(2):210-219.WU D,GAO Y,XIANG H,et al.Exploration into mechanism of antidepressant of Bupleuri radix based on network pharmacology ［J］.Acta Pharmaceutica Sinica,2018,53(2):210-219.
［41］　HSU Y L,KUO P L,LIN C C.The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells［J］.Life Sci,2004,75(10):1231-1242.
［42］　WANG J,QI H,ZHANG X,et al.Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling［J］.Biomed Pharmacother,2018,108:724-733.
［43］　王艳丽,和水祥,罗金燕,等.柴胡皂甙d对肝癌SMMC-7721细胞增殖的抑制作用［J］.西安交通大学学报(医学版),2006,27(6):572-574.WANG Y L,HE S X,LUO J Y,et al.Inhibitory effect of saikosaponin-d on human hepatocellular carcinoma cell line SMMC-7721 proliferation［J］.J Xi′an Jiaotong Univ（Med Sci）,2006,27(6):572-574.
［44］　ASHOUR M L,YOUSSEF F S,GAD H A,et al.Evidence for the anti-inflammatory activity of Bupleurum marginatum (Apiaceae) extracts using in vitro and in vivo experiments supported by virtual screening［J］.J Pharm Pharmacol,2018,70(7):952-963.
［45］　张喆,赵静洁,王永志,等.柴胡疏肝散药理作用及机制研究进展［J］.中国中医药信息杂志,2017,24(9):128-131.ZHANG Z,ZHAO J J,WANG Y Z,et al.Research progress on pharmacological effects and mechanism of Chaihu Shugan Powder［J］.Chin J Inform Trad Chin Med,2017,24(9):128-131.
［46］　余刘勤,贾爱梅,宋永砚.柴胡皂苷抗炎、抗氧化和降脂研究进展［J］.中国动脉硬化杂志,2020,28(1):87-92.YU L Q,JIA A M,SONG Y Y.Progress in the study of saikosaponins on anti-inflammation,anti-oxidation and lipid-lowering effects［J］.Chin J Arterioscl,2020,28(1):87-92.
［47］　霍梦逸.热可平注射剂(柴胡部分)解热抗炎有效部位研究［D］.重庆:重庆医科大学,2013.HUO M Y.Study on antipyretic and anti-inflammatory parts of Rekeping injection (Bupleurum part) ［D］.Chongqing:Chongqing Medical University,2013.
［48］　成睿珍,张春艳.柴胡皂苷类药理活性的研究进展［J］.职业与健康,2021,37(4):568-572,576.CHENG R Z,ZHANG C Y.Research progress on pharmacological activities of Saikosaponin s from Radix Bupleurum［J］.Occup Health,2021,37(4):568-572,576.
［49］　侯俊宇,李明慧,许梦然,等.北柴胡多糖对D-gal诱导的HK-2细胞氧化损伤的保护作用［J］.吉林大学学报(医学版),2022,48(1):65-73.HOU J Y,LI M H,XU M R,et al.Protective effect of Bupleurum chinense polysaccharides on oxidative damage of HK-2 cells induced by D-gal［J］.J Jilin Univ (Med Edit),2022,48(1):65-73.
［50］　高丽萍.柴胡有效成分与药理作用探究［J］.临床医药文献电子杂志,2017,4(70):13853-13854.GAO L P.Study on active components and pharmacological action of Bupleurum［J］.J Clin Med,2017,4(70):13853-13854.
［51］　YAO J,ZHANG H,MA L,et al.Effect of traditional Chinese medicine Bupleurum in the treatment of influenza A(H1N1)［J］.Pak J Pharm Sci,2018,31(4):1713-1717.
［52］　张耀峰.中药柴胡皂苷药理作用的研究进展［J］.中医临床研究,2020,12(33):120-121.ZHANG Y F.Advances in pharmacological effects of saikosaponins from Bupleurum chinense［J］.Clin J Chin Med,2020,12(33):120-121.
［53］　XIAN Y,ZHANG J,BIAN Z,et al.Bioactive natural compounds against human coronaviruses:a review and perspective［J］.Acta Pharm Sini B,2020,10(7):1163-1174.
［54］　YUAN B,YANG R,MA Y,et al.A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications［J］.Pharm Bio,2017,55(1):620-635.
［55］　姜伟超,周亚滨.柴胡桂枝龙骨牡蛎汤加减治疗心脏神经症临床研究［J］.中国中医急症,2015,24(7):1146-1148.JIANG W C,ZHOU Y B.The clinical research on modified treatment with Chaihuguizhi Longgumuli Tang on cardiacneurosis［J］.J Emerg Trad Chin Med,2015,24(7):1146-1148.
［56］　王怡茹,韦婧,刘萍.柴胡中药制剂治疗心脏神经官能症效果的系统评价和meta分析［J］.中国医药导报,2020,17(8):164-169,181.WANG Y R,WEI J,LIU P.Systematic evaluation and meta-analysis of effect of Radix Bupleuri medication in the treatment of cardiac neurosis［J］.China Med Herald,2020,17(8):164-169,181.
［57］　陈静,孙浪,罗林,等.柴胡皂苷d对离体蟾蜍心脏功能的影响［J］.中国老年学杂志,2019,39(3):659-663.CHEN J,SUN L,LUO L,et al.Effect of saikosaponin-d on the function of the heart isolated from toad［J］.Chin J Geront,2019,39(3):659-663.
［58］　邢颖,张冬芹,杨静云,等.柴胡皂苷在离体大鼠I/R后心肌保护作用的研究［J］.心血管康复医学杂志,2022,31(4):479-484.XING Y,ZHANG D Q,YANG J Y,et al.Study of myocardial protective effect of Saikosaponin on isolated rats after I/R［J］.Chin J Card Rehab Med,2022,31(4):479-484.
［59］　李龙春,李晓晔,杜小华,等.大柴胡汤通过CREB/PGC-1α通路保护营养型肥胖大鼠肝脏粒体功能［J］.中国实验方剂学杂志,2021,27(9):26-31.LI L C,LI X Y,DU X H,et al.Da Chaihutang protects liver mitochondrial function of nutritionally obese rats via CREB/PGC-1α pathway［J］.Chin J Exper Trad Med Form,2021,27(9):26-31.
［60］　李晋,徐尚福,李远洋,等.小柴胡汤对肝纤维化大鼠肝脏MMP-2、TIMP-2表达的影响［J］.辽宁中医杂志,2018,45(5):1066-1068,1119.LI J,XU S F,LI Y Y,et al.Effects of Xiaochaihu decoction on expressions of TIMP-2 and MMP-2 in rats with hepatic fibrosis［J］.Liaoning J Trad Chin Med,2018,45(5):1066-1068,1119.
［61］　JIANG W,LI D,JIANG T,et al.Protective effects of Chaihu Shugan San (柴胡疏肝散) on nonalcoholic fatty liver disease in rats with insulin resistance［J］.Chin J Integr Med,2018,24(2):125-132.
［62］　黄幼异,黄伟,孙蓉.柴胡皂苷对肝脏的药理毒理作用研究进展［J］.中国实验方剂学杂志,2011,17(17):298-301.HUANG Y Y,HUANG W,SUN R.Research development on pharmacological effects and hepatotoxicity of Bupleurum saikosaponin［J］.Chin J Exper Trad Med Form,2011,17(17):298-301.
［63］　鲍清辉,黄新艳.大柴胡汤治疗肾脏病医案3则［J］.光明中医,2021,36(4):634-635.BAO Q H,HUANG X Y.Medical records of Dachaihu decoction in the treatment of kidney disease［J］.Guangming J Chin Med,2021,36(4):634-635.
［64］　张锴.周清发教授应用小柴胡汤治疗肾脏疾病两则［J］.陕西中医,2015,36(10):1408-1409.ZHANG K.Professor Zhou Qingfa used Xiao Chaihu decoction to treat two kidney diseases ［J］.Shaanxi J Trad Chin Med,2015,36(10):1408-1409.
［65］　李月阳,雷根平,董盛,等.柴胡的现代药理作用研究进展［J］.海南医学院学报,2022,28(22):1748-1754.LI Y Y,LEI G P,DONG S,et al.Research progress on modern pharmacological action of Radix bupleuri［J］.J Hainan Med Univ,2022,28(22):1748-1754.
［66］　赵琼,刘恒军.柴胡皂苷D对克雷伯杆菌肺炎大鼠肺组织损伤和纤维化及免疫功能的调节作用［J］.沈阳药科大学学报,2019,36(9):823-829.ZHAO Q,LIU H J.The regulating effect of saikosaponin D on lung tissue injury,fibrosis and immune function in klebsiella pneumoniae rats［J］.J Shenyang Pharm Univ,2019,36(9):823-829.
［67］　RUIQI L,MING P,QIHANG S,et al.Saikosaponin D inhibits peritoneal fibrosis in rats with renal failure by regulation of TGFβ1/BMP7/Gremlin1/Smad pathway［J］.Front Pharmacol,2021,12:628671.
［68］　ZHOU L,HUANG J Y,ZHANG D,et al.Cognitive improvements and reduction in amyloid plaque deposition by saikosaponin D treatment in a murine model of Alzheimer′s disease［J］.Exp Ther Med,2020,20(2):1082-1090.
［69］　XU M,SUN S,GE J,et al.Bupleurum chinense polysaccharide improves LPS-induced senescence of RAW264.7 cells by regulating the NF-κB signaling pathway［J］.Evid Based Complement Alternat Med,2020,2020:7060812.
［70］　陈启亮,于清茜,李灿东,等.柴胡疏肝散的历史沿革与现代药理作用［J］.辽宁中医杂志,2022,49(4):215-217.CHEN Q L,YU Q Q,LI C D,et al.Historical evolution and modern pharmacological action of Chaihu Shugan powder［J］.Liaoning J Trad Chin Med,2022,49(4):215-217.
［71］　YE M,BI Y F,DING L,et al.Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway［J］.Biomed Pharmacother,2016,81:281-287.
［72］　SHU G,XU D,RAN C,et al.Protective effect of dietary supplementation of Bupleurum falcatum L saikosaponins on ammonia exposure-induced ileum injury in broilers［J］.Poult Sci,2021,100(3):100803.

相似文献/References:

[1]孙　华,李春燕,薛金涛.葛根的化学成分及药理作用研究进展[J].新乡医学院学报,2019,36(11):1097.[doi:10.7683/xxyxyxb.2019.11.022]
[2]迟宇昊,李　暘,申　远.麦冬化学成分及药理作用研究进展[J].新乡医学院学报,2021,38(2):189.[doi:10.7683/xxyxyxb.2021.02.020]
[3]杜晓妍,吴　娇.茯苓的化学成分和药理作用研究进展[J].新乡医学院学报,2021,38(5):496.[doi:10.7683/xxyxyxb.2021.05.022]
[4]冬海洋,李彦灵,马矜烁,等.中药牛膝叶化学成分分析[J].新乡医学院学报,2020,37(1):012.[doi:10.7683/xxyxyxb.2020.01.004]
　DONG Haiyang,LI Yanling,MA Jinshuo,et al.Analysis of chemical constituents of Achyranthes bidentata leaf[J].Journal of Xinxiang Medical University,2020,37(2):012.[doi:10.7683/xxyxyxb.2020.01.004]
[5]吴　娇,王　聪.黄芪的化学成分及药理作用研究进展[J].新乡医学院学报,2018,35(9):755.[doi:10.7683/xxyxyxb.2018.09.002]
　N/A.N/A[J].Journal of Xinxiang Medical University,2018,35(2):755.[doi:10.7683/xxyxyxb.2018.09.002]
[6]殷田田,白意晓,庄方方,等.高莴苣化学成分研究[J].新乡医学院学报,2016,33(2):091.[doi:10.7683/xxyxyxb.2016.02.003]
　YIN Tian-tian,BAI Yi-xiao,ZHUANG Fang-fang,et al.Chemical constituents of Lactuca elata[J].Journal of Xinxiang Medical University,2016,33(2):091.[doi:10.7683/xxyxyxb.2016.02.003]
[7]曹　轲,丁明明,庄方方,等.中药糙苏中的环烯醚萜类化合物[J].新乡医学院学报,2016,33(3):164.[doi:10.7683/xxyxyxb.2016.03.002]
　CAO Ke,DING Ming-ming,ZHUANG Fang-fang,et al.Iridoid compounds from Phlomis umbrosa of herb medicine[J].Journal of Xinxiang Medical University,2016,33(2):164.[doi:10.7683/xxyxyxb.2016.03.002]
[8]刘军伟,吕洁丽,张来宾.山药地上部分石油醚部位的化学成分研究[J].新乡医学院学报,2016,33(6):457.[doi:10.7683/xxyxyxb.2016.06.003]
　LIU Jun-wei,LYU Jie-li,ZHANG Lai-bin.Chemical constituents of the petroleum ether fraction from the aerial part of Dioscorea opposita[J].Journal of Xinxiang Medical University,2016,33(2):457.[doi:10.7683/xxyxyxb.2016.06.003]
[9]周慧超,贺　爽,宋　宇,等.全缘橐吾根部化学成分及生物活性研究[J].新乡医学院学报,2016,33(12):1017.[doi:10.7683/xxyxyxb.2016.12.001]
　ZHOU Hui-chao,HE Shuang,SONG Yu,et al.Chemical constituents and biological activity of Ligularia mongolica root[J].Journal of Xinxiang Medical University,2016,33(2):1017.[doi:10.7683/xxyxyxb.2016.12.001]
[10]肖先,李春燕,刘晓龙,等.甘草的主要化学成分及药理作用研究进展[J].新乡医学院学报,2023,40(3):280.[doi:10.7683/xxyxyxb.2023.03.016]
　XIAO Xian,LI Chunyan,LIU Xiaolong,et al.Research progress of main chemical constituents and pharmacological effects of Glycyrrhizae Radix et Rhizoma[J].Journal of Xinxiang Medical University,2023,40(2):280.[doi:10.7683/xxyxyxb.2023.03.016]

更新日期/Last Update: 2023-02-05