[1]曹　轲,丁明明,庄方方,等.中药糙苏中的环烯醚萜类化合物[J].新乡医学院学报,2016,33(3):164-168.[doi:10.7683/xxyxyxb.2016.03.002]
　CAO Ke,DING Ming-ming,ZHUANG Fang-fang,et al.Iridoid compounds from Phlomis umbrosa of herb medicine[J].Journal of Xinxiang Medical University,2016,33(3):164-168.[doi:10.7683/xxyxyxb.2016.03.002]
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中药糙苏中的环烯醚萜类化合物
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年3
页码:
164-168
栏目:
基础研究
出版日期:
2016-03-05

文章信息/Info

Title:
Iridoid compounds from Phlomis umbrosa of herb medicine
作者:
曹　轲1; 丁明明2; 庄方方1; 殷田田1; 闫福林1
（1.新乡医学院药学院,河南　新乡　453003;2.南阳市中心医院药学部,河南　南阳　473009）
Author(s):
CAO Ke1; DING Ming-ming2; ZHUANG Fang-fang1; YIN Tian-tian1; YAN Fu-lin1
(1.School of Pharmacy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.Department of Pharmaceutical,the Central Hospital of Nanyang,Nanyang 473009,Henan Province,China)
关键词:
糙苏; 化学成分; 环烯醚萜; 提取分离
Keywords:
Phlomis umbrosa; chemical constituents; iridoid; extraction separation
分类号:
R284.2
DOI:
10.7683/xxyxyxb.2016.03.002
文献标志码:
A
摘要:
目的　研究糙苏叶中的化学成分。方法　采用柱层析对糙苏叶中的提取物进行分离提纯，并利用现代波谱方法分析鉴定，确定化合物的结构。结果　分离并鉴定出10个环烯醚萜类化合物，它们分别为：(1S*,3R*,4S*,5S*,6R*,7R*,8S*,9S*)-3,8-epoxy-1-hydroxy-4-methoxycarbonyl-10-methyl-6,7-acetonide-cis-2-oxabicyclo［4.3.0］ nonane(1),(1R*,3R*,4S*,5S*,6R*,7R*,8S*,9S*)-3,8-epoxy-1-hydroxy-4-methoxycarbonyl-10-methyl-6,7-acetonide-cis-2-oxabicyclo［4.3.0］ nonane(2),8-acetylshanzhigenin methyl ester(3),8-acetyl-1-epishanzhigenin methyl ester(4),shanzhigenin methyl ester(5),1-epishanzhigenin methyl ester(6),1β-hydroxy-dihydrocornin aglycone(7),1α-hydroxy-dihydrocornin aglycone(8),独一味素A(9),独一味素B(10)。结论　从糙苏叶中分离得到的10个化合物中,化合物1、2、7和8为首次从该属植物中分离得到。
Abstract:
Objective　To study the chemical constituents of Phlomis umbrosa.Methods　The compounds of iridoid were isolated by means of silica gel column chromatography and elucidated by spectroscopic experiments.Results　Ten iridoid compounds isolated from the air-dried and powdered leaves of Phlomis umbrosa Turcz.All these compounds were as follows：(1S*,3R*,4S*,5S*,6R*,7R*,8S*,9S*)-3,8-epoxy-1-hydroxy-4-methoxycarbon-yl-10-methyl-6,7-acetonide-cis-2-oxabicyclo［4.3.0］ nonane(1);(1R*,3R*,4S*,5S*,6R*,7R*,8S*,9S*)-3,8-epoxy-1-hydroxy-4-methoxycarbonyl-10-methyl-6,7-acetonide-cis-2-ox-abicyclo［4.3.0］ nonane(2);8-acetylshanzhigenin methyl ester(3);8-acetyl-1-epishanzhig-enin methyl ester(4);shanzhigenin methyl ester(5);1-epishanzhigenin methyl ester(6);1β-hydroxy-dihydrocornin aglycone(7);1α-hydroxy-dihydrocornin aglycone(8);lamiophlomiol A(9);lamiophlomiol B(10).Conclusion　Compounds 1,2,7 and 8 were all first isolated from the genus.

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更新日期/Last Update: 2016-03-05