[1]李清红,王晓宇,栗夏莲.2型糖尿病并发原发性高血压患者心脏结构和功能变化[J].新乡医学院学报,2018,35(4):314-316.[doi:10.7683/xxyxyxb.2018.04.014]
 LI Qing-hong,WANG Xiao-yu,LI Xia-lian.Changes of cardiac structure and function in patients with type 2 diabetes mellitus complicated with essential hypertension[J].Journal of Xinxiang Medical University,2018,35(4):314-316.[doi:10.7683/xxyxyxb.2018.04.014]
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2型糖尿病并发原发性高血压患者心脏结构和功能变化
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年4
页码:
314-316
栏目:
临床研究
出版日期:
2018-04-05

文章信息/Info

Title:
Changes of cardiac structure and function in patients with type 2 diabetes mellitus complicated with essential hypertension
作者:
李清红1王晓宇2栗夏莲2
(1.解放军第91中心医院内分泌科,河南 焦作 410800;2.郑州大学第一附属医院内分泌科,河南 郑州 450052)
Author(s):
LI Qing-hong1WANG Xiao-yu2LI Xia-lian2
(1.Department of Endocrinology,the 91st Central Hospital of PLA,Jiaozuo 410800,Henan Province,China;2.Department of Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)
关键词:
2型糖尿病原发性高血压超声心动图心脏结构心脏功能
Keywords:
type 2 diabetes mellitusessential hypertensionechocardiographycardiac structurecardiac function
分类号:
R587.1R544.1
DOI:
10.7683/xxyxyxb.2018.04.014
文献标志码:
A
摘要:
目的 探讨2型糖尿病(T2DM)并发原发性高血压(EH)患者的心脏结构和功能变化特点。方法 选择2015年1月至2016年12月解放军第91中心医院收治的T2DM患者487例(T2DM组)和T2DM并发EH患者450例(T2DM+EH组),并选择同期健康者140例为对照组,所有受试者使用彩色多普勒超声仪进行心脏超声心动图检查,对3组受试者的左心室舒张末期内径(LVIDD)、右心室舒张末期内径(RVIDD)、左心房内径(LAD)、左心室后壁厚度(LVPWT)、室间隔厚度(IVST)、肺动脉瓣环内径(PVAD)、右心房面积(RAA)、二尖瓣口舒张早期最大充盈速度(E峰)、二尖瓣口舒张晚期最大充盈速度(A峰)、E/A及左心室射血分数(LVEF)进行比较。结果 3组受试者RVIDD、RAA比较差异无统计学意义(P>0.05)。T2DM组患者IVST、LVPWT、LAD、PVAD显著大于对照组(P<0.05),T2DM+EH组患者IVST、LVIDD、LVPWT、LAD、PVAD显著大于对照组(P<0.05),T2DM+EH组患者IVST、LVPWT、LAD显著大于T2DM组(P<0.05)。与对照组比较,T2DM组和T2DM+EH组患者E峰、E/A、LVEF显著减低,A峰均显著升高(P<0.05)。T2DM+EH组患者A峰、E/A显著低于T2DM组(P<0.05),但2组患者E峰、LVEF比较差异无统计学意义(P>0.05)。结论 T2DM并发EH患者心脏结构改变主要为左心室肥厚、左心房增大及肺动脉增宽,心脏功能改变主要为收缩和舒张功能障碍,以舒张功能障碍更显著。
Abstract:
Objective To investigate the changes of cardiac structure and function in patients with type 2 diabetes mellitus (T2DM) complicated with essential hypertension (EH).Methods A total of 487 cases of T2DM (T2DM group) and 450 cases of T2DM complicated with EH (T2DM+EH group) were selected from January 2015 to December 2016 in the 91st Central Hospital of PLA,and 140 healthy subjects were selected as the control group in the same period.All subjects underwent color Doppler echocardiography.The left ventricular internal diameter at end-diastole (LVIDD),right ventricular internal diameter at end-diastole (RVIDD),left atrial dimension (LAD),left ventricular posterior wall thickness (LVPWT),interventricular septal thickness (IVST),the pulmonary valve annulus diameter (PVAD),right atrium area (RAA),the maximum filling velocity of the early diastolic phase of mitral valve (E peak),the maximum filling velocity of the late diastolic end of mitral valve (A peak),E/A and left ventricular ejection fraction (LVEF) were compared in the three groups.Results There were no significant difference in the RVIDD and RAA in the three groups(P>0.05).The IVST,LVPWT,LAD and PVAD in the T2DM group were significantly greater than those in the control group(P<0.05).The IVST,LVIDD,LVPWT,LAD and PVAD in the T2DM+EH group were significantly greater than those in the control group (P<0.05).The IVST,LVPWT and LAD in the T2DM+EH group were significantly greater than those in the T2DM group (P<0.05).Compared with the control group,the E peak,E/A and LVEF decreased significantly,and the A peak increased significantly in the T2DM group and the T2DM+EH group (P<0.05).The A peak and E/A in the T2DM+EH group were significantly lower than those in the T2DM group (P<0.05),but there was no significant difference in the E peak and LVEF between the two groups (P>0.05).Conclusion The cardiac structural changes in patients with T2DM complicated with EH are mainly left ventricular hypertrophy,left atrial enlargement and pulmonary artery widening.The cardiac function changes are mainly systolic and diastolic dysfunction,and the diastolic dysfunction is more significant.

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更新日期/Last Update: 2018-04-05