[1]贾如江,侯丽艳,尹清臣,等.轴突诱导因子4D和血管内皮生长因子在胰腺癌组织中的表达[J].新乡医学院学报,2016,33(11):950-953.[doi:10.7683/xxyxyxb.2016.11.004]
　JIA Ru-jiang,HOU Li-yan,YIN Qing-chen,et al.Clinical significance of the expression of semaphorin 4D and vascular endothelial growth factor in pancreatic carcinoma[J].Journal of Xinxiang Medical University,2016,33(11):950-953.[doi:10.7683/xxyxyxb.2016.11.004]
点击复制

轴突诱导因子4D和血管内皮生长因子在胰腺癌组织中的表达
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年11
页码:
950-953
栏目:
基础研究
出版日期:
2016-11-05

文章信息/Info

Title:
Clinical significance of the expression of semaphorin 4D and vascular endothelial growth factor in pancreatic carcinoma
作者:
贾如江; 侯丽艳; 尹清臣; 任利兵; 杨庚武
(邯郸市中心医院普外一科，河北　邯郸　056102)
Author(s):
JIA Ru-jiang; HOU Li-yan; YIN Qing-chen; REN Li-bing; YANG Geng-wu
(Department of General Surgery,Handan Central Hospital,Handan 056102，Hebei Province,China)
关键词:
胰腺癌; 轴突诱导因子4D; 免疫组织化学; 血管内皮生长因子
Keywords:
pancreatic carcinoma; semaphorin 4D; immunohistochemistry; vascular endothelial growth factor
分类号:
R735.9
DOI:
10.7683/xxyxyxb.2016.11.004
文献标志码:
A
摘要:
目的　探讨轴突诱导因子4D（Sema 4D）和血管内皮生长因子（VEGF）在胰腺癌组织中的表达及其临床意义。方法　采用免疫组织化学法检测43例胰腺癌组织和10例癌旁组织中Sema 4D和VEGF的表达，分析Sema 4D和VEGF在胰腺癌组织中表达的相关性,以及胰腺癌组织中Sema 4D和VEGF的表达与临床病理特征、患者预后的关系。结果　Sema 4D和VEGF在胰腺癌组织中的阳性表达率分别为51.2%（22/43）和46.5%（20/43），在癌旁组织中的阳性表达率分别为10.0%（1/10）和20.0%（2/10）,Sema 4D和VEGF在胰腺癌组织中的阳性表达率均显著高于癌旁组织（P<0.01）。胰腺癌组织中Sema 4D和VEGF的表达呈正相关（r=0.445,P<0.05）。Sema 4D和VEGF的阳性表达均与肿瘤分期、淋巴结转移、脉管内瘤栓有关（P<0.05），与患者的性别、年龄、分化程度、肿瘤直径无关（P>0.05）。VEGF表达阳性者中位生存时间低于VEGF表达阴性者（P<0.05）。Sema 4D表达阳性者中位生存时间与Sema 4D表达阴性者差异无统计学意义（P>0.05）。结论　Sema 4D和VEGF在胰腺癌组织中异常表达可能与胰腺癌的发生发展有一定关系，且二者可能对诱导血管新生具有协同效应；VEGF的表达与胰腺癌预后有关。
Abstract:
Objective　To study the clinical significance of the expression of semaphorin 4D(Sema 4D) and vascular endothelial growth factor(VEGF) in pancreatic carcinoma.Methods　The expressions of Sema 4D and VEGF in 43 cases of pancreatic cancer and 10 cases of adjacent tissues were detected by immunohistochemistry.The correlation between Sema 4D and VEGF expression in pancreatic cancerwas analyzed.The relationship between Sema 4D or VEGF expression and clinical pathological characteristics or prognosis of patients was analyzed.Results　The positive rates of Sema 4D and VEGF in pancreatic cancer tissues were 51.2%(22/43) and 46.5%(20/43),and them in adjacent tissues were 10.0%(1/10) and 20.0%(2/10);the positive rates of Sema 4D and VEGF in pancreatic cancer tissues were significantly higher than those in adjacent tissues(P<0.01).The expression of Sema 4D was positively correlated with the expression of VEGF in pancreatic cancer tissues(r=0.445,P<0.05).The abnormal expression of Sema 4D and VEGF was related to tumor staging,lymph node metastasis and vascular tumor thrombus (P<0.05),but it was not related to the sex,age,degree of differentiation and tumor size(P>0.05).The live time in patients with positive expression of VEGF was significantly lower than that in patients with negative expression of VEGF(P<0.05).There was no significant difference in the live time between the patients with positive expression of Sema 4D and the patients with negative expression of Sema 4D (P>0.05).Conclusion　The abnormal expression of Sema 4D and VEGF is related to the occurrence and development of pancreatic cancersex,and Sema 4D and VEGF may have a synergistic effect on the induction of angiogenesis.The expression of VEGF may be related to the prognosis of pancreatic cancer.

参考文献/References:

［1］　YOUNIS R H,HAN K L,WEBB T J.Semaphorin 4D produced by human head and neck squamous cell carcinoma induces myeloid derived suppressor cells expansion from peripheral blood monocytes［J］.J Immunol Ther Canc，2015,3(Suppl 2):280-281.
［2］　DING X,QIU L,ZHANG L,et al.The role of semaphorin 4D as a potential biomarker for antiangiogenic therapy in colorectal cancer［J］.Onco Targets Ther，2016,9:1189-1204.
［3］　BELLOU S,PENTHEROUDAKIS G,MURPHY C,et al.Anti-angiogenesis in cancer therapy:hercules and hydra［J］.Cancer Lett,2013,338(2):219-228.
［4］　YOUNIS R H,HAN K L,WEBB T J.Human head and neck squamous cell carcinoma-associated Semaphorin 4D induces expansion of myeloid-derived suppressor cells［J］.J Immunol，2016,196(3):1419-1429.
［5］　KATO S,KUBOTA K,SHIMAMURA T,et al.Semaphorin 4D：a lymphocyte semaphorin,enhances tumor cell motility through binding its receptor,plexinB1,in pancreatic cancer［J］.Cancer Sci，2011，102(11):2029-2037.
［6］　SUN Q,ZHOU H,BINMADI N O,et al.Hypoxia-inducible factor-1-mediated regulation of semaphorin 4D affects tumor growth and vascularity［J］.J Biol Chem，2009，284(46):32066-32074.
［7］　ZHOU H,YANG Y H,BASILE J R.The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4［J］.Angiogenesis，2014,17(1):261-274.
［8］　闫小晨,张连栋.血清恶性肿瘤特异性生长因子及肝细胞生长因子水平对膀胱癌新生血管相关因子的影响［J］.川北医学院学报，2016，31(3)：291-293.
［9］　张涓娟，蒲宇，李勇，等.PI3K/AKT和MAPK/ERK1/2信号通路对胰腺癌PANC-1细胞VEGF表达的影响［J］.川北医学院学报，2014，29(1)：44-48.
［10］　熊义富,李丽,徐浩,等.HIF-1α/VEGF在肝细胞癌的表达及其与肿瘤血管生成的关系［J］.川北医学院学报，2013，28(6)：530-533.
［11］　WU K,YANG L,HUANG Z,et al.A double suicide gene system driven by vascular endothelial growth factor promoter selectively kills human hepatocellular carcinoma cells［J］.Oncol Lett，2016,11(5):3152-3160.
［12］　彭勇,胡韬,田云鸿,等.精准胰腺外科在胰腺肿瘤切除中的应用［J］.川北医学院学报，2014,29(2):125-128.
［13］　陈建峰.HIF-1α、VEGF在胰腺癌组织中的表达及临床意义［J］.肝胆胰外科杂志，2008，20（5）：43-46.
［14］　PATNAIK A,WEISS G J,LEONARD J E,et al.Safety,pharmacokinetics,and pharmacodynamics of a humanized anti-Semaphorin 4D antibody,in a first-in-human study of patients with advanced solid tumors［J］.Clin Cancer Res，2016,22(4):827-836.
［15］　KATO S,KUBOTA K,SHIMAMURA T,et al.Semaphorin 4D,a lymphocyte semaphorin,enhances tumor cell motility through binding its receptor,plexinB1,in pancreatic cancer［J］.Cancer Sci，2011,102(11):2029-2037.

相似文献/References:

[1]李　丽,赵江海.立体定向低分割适形放射治疗胰腺癌38 例临床观察与护理[J].新乡医学院学报,2006,23(06):626.
[2]刘宝军,周建华,包金英.替吉奥用于转移性胰腺癌治疗的研究进展[J].新乡医学院学报,2012,29(01):000.
[3]贾如江,侯丽艳,尹清臣,等.轴突诱导因子4D对人胰腺癌细胞增殖、迁移及血管生成的影响[J].新乡医学院学报,2017,34(12):1063.[doi:10.7683/xxyxyxb.2017.12.005]
　JIA Ru-jiang,HOU Li-yan,YIN Qing-chen,et al.Effect of semaphorin 4D on the proliferation，migration and angiogenic of human pancreatic carcinoma cells[J].Journal of Xinxiang Medical University,2017,34(11):1063.[doi:10.7683/xxyxyxb.2017.12.005]
[4]盖守娟.细胞周期蛋白依赖性激酶抑制因子2A基因表达与胰腺癌临床病理特征的关系[J].新乡医学院学报,2021,38(6):573.[doi:10.7683/xxyxyxb.2021.06.016]
　GAI Shoujuan.Relationship between the expression of cyclin-dependent kinase inhibitor 2A gene and clinicopathological features of pancreatic cancer[J].Journal of Xinxiang Medical University,2021,38(11):573.[doi:10.7683/xxyxyxb.2021.06.016]
[5]彭青侠,许小凡,段丽芳,等.细胞外囊泡在胰腺癌中的作用研究进展[J].新乡医学院学报,2021,38(9):893.[doi:10.7683/xxyxyxb.2021.09.021]
[6]熊慧敏,许小凡,段丽芳,等.白细胞介素-6在胰腺炎症和肿瘤中的作用机制研究进展[J].新乡医学院学报,2019,36(12):1191.[doi:10.7683/xxyxyxb.2019.12.022]
[7]田龙夫,崔云峰,张　琦,等.天然植物中生物碱类药物抗胰腺癌作用的研究进展[J].新乡医学院学报,2018,35(4):343.[doi:10.7683/xxyxyxb.2018.04.023]
　N/A.N/A[J].Journal of Xinxiang Medical University,2018,35(11):343.[doi:10.7683/xxyxyxb.2018.04.023]

更新日期/Last Update: 2016-11-05