参考文献/References:
[1] OLADIPUPO S S,SMITH C,SANTEFORD A,et al.Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis[J].Proc Natl Acad Sci USA,2014,111(37):13379-13384.
[2] MILLER A V,KAVANAUGH S I,TSAI P S.Disruption of the suprachiasmatic nucleus in fibroblast growth factor signaling-deficient mice[J].Front Endocrinol (Lausanne),2016,8(2):7-11.
[3] FENG S,ZHOU L,NICE E C,et al.Fibroblast growth factor receptors:multifactorial-contributors to tumor initiation and progression[J].Histol Histopathol,2015,30(1):13-31.
[4] GRYSHCHENKO A A,BDZHOLA V G,BALANDA A O,et al.Design,synthesis and biological evaluation of N-phenylthieno[2,3-d]pyrimidine-4-amines as inhibitors of FGFR1[J].Bioorg Med Chem,2015,23(9):2287-2293.
[5] SAICHAEMCHAN S,ARIYAWUTYAKORN W,VARELLA-GARCIA M.Fibroblast growth factor receptors:from the oncogenic pathway to targeted therapy[J].Curr Mol Med,2016,16(1):40-62.
[6] SHI Y J,TSANG J Y,NI Y B,et al.FGFR1 is an adverse outcome indicator for luminal A breast cancers[J].Oncotarget,2016,7(4):5063-5073.
[7] ZHANG W,XUE D,HU D,et al.Secreted klotho protein attenuates osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro via inactivation of the FGFR1/ERK signaling pathway[J].Growth Factors,2015,33(5/6):356-365.
[8] 付坤,辛毅,史雨晨,等.成纤维细胞生长因子21对大鼠血管平滑肌钙化的影响及机制[J].中华心血管病杂志,2015,43(10):879-886.
[9] 王柏川,叶剑.地塞米松对大鼠晶状体上皮细胞成纤维细胞生长因子受体表达的影响[J].眼科新进展,2007,27(10):750-753.
[10] FISCHBACH A,ROGLER A,ERBER R,et al.Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer[J].Histopathology,2015,66(5):639-649.
[11] SPOLCOVA A,HOLUBOVA M,MIKULASKOVA B,et al.Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes[J].Physiol Res,2014,63(4):483-490.
[12] HERO M,LAITINEN E M,VARIMO T,et al.Childhood growth of females with Kallmann syndrome and FGFR1 mutations[J].Clin Endocrinol (Oxf),2015,82(1):122-126.
[13] LING L,TAN S K,GOH T H,et al.Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy[J].Mol Cancer,2015,14:136.
[14] BREWER J R,MOLOTKOV A,MAZOT P,et al.Fgfr1 regulates development through the combinatorial use of signaling proteins[J].Genes Dev,2015,29(17):1863-1874.
[15] KUMAR B V,LAKSHMI N,KUMAR M R,et al.Design,synthesis and screening studies of potent thiazol-2-amine derivatives as fibroblast growth factor receptor 1 inhibitors[J].Curr Top Med Chem,2014,14(17):2031-2041.
[16] BOEHM D,VON MASSENHAUSEN A,PERNER S.Analysis of receptor tyrosine kinase gene amplification on the example of FGFR1[J].Methods Mol Biol,2015,1233:67-79.
[17] PARISH A,SCHWAEDERLE M,DANIELS G,et al.Fibroblast growth factor family aberrations in cancers:clinical and molecular characteristics[J].Cell Cycle,2015,14(13):2121-2128.
[18] KLEIN T,VAJPAI N,PHILLIPS J J,et al.Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase[J].Nat Commun,2015,6:7877.
[19] ZHUANG L,BLUTEAU G,TRUEB B.Phylogenetic analysis of receptor FgfrL1 shows divergence of the C-terminal end in rodents[J].Comp Biochem Physiol B Biochem Mol Biol,2015,186:43-50.
[20] KELLEHER F C,O′SULLIVAN H,SMYTH E,et al.Fibroblast growth factor receptors,developmental corruption and malignant disease[J].Carcinogenesis,2013,34(10):2198-2205.
[21] BARIK M,BAJPAI M,MALHOTRA A,et al.Novel mutation detection of fibroblast growth factor receptor 1 (FGFR1) gene,FGFR2Ⅲa,FGFR2Ⅲb,FGFR2Ⅲc,FGFR3,FGFR4 gene for craniosynostosis:a prospective study in Asian Indian patient[J].J Pediatr Neurosci,2015,10(3):207-213.
[22] ANTONELLIS P J,KHARITONENKOV A,ADAMS A C.Physiology and endocrinology symposium:FGF21:insights into mechanism of action from preclinical studies[J].J Anim Sci,2014,92(2):407-413.
[23] ASRIH M,ALTIRRIBA J,ROHNER-JEANRENAUD F,et al.Ketogenic diet impairs FGF21 signaling and promotes differential inflammatory responses in the liver and white adipose tissue[J].PLoS One,2015,10(5):e126364.
[24] 史雨晨,柳景华.成纤维细胞生长因子21在大鼠各组织中表达分布的研究[J].心肺血管病杂志,2016,35(7):574-577.
[25] HOUSE S L,CASTRO A M,LUPU T S,et al.Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury[J].Am J Physiol Heart Circ Physiol,2016,310(5):H559-H571.
[26] KUO C H,SUNG M C,CHEN P K,et al.FGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis[J].Cardiovasc Res,2015,105(1):107-117.
[27] 丁芝祥,陈阳.FGFs及其受体与后囊膜混浊的研究进展[J].医学综述,2014,20(5):775-778.
[28] 张静,李晓莉,王萌,等.成纤维细胞生长因子受体-癌症治疗新靶点[J].现代生物医学进展,2015,15(17):3393-3397,3352.
[29] GALLEGO-ESCUREDO J M,GOMEZ-AMBROSI J,CATALAN V,et al.Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients[J].Int J Obes (Lond),2015,39(1):121-129.
[30] 周文雅,王国文,杨蕴,等.肉瘤中FGFR信号通路研究进展[J].中国骨与关节杂志,2015,4(9):720-724.
[31] JUNG S H,LEE H C,YU D M,et al.Heparan sulfation is essential for the prevention of cellular senescence[J].Cell Death Differ,2016,23(3):417-429.
[32] SARFATI J,BOUVATTIER C,BRY-GAUILLARD H,et al.Kallmann syndrome with FGFR1 and KAL1 mutations detected during fetal life[J].Orphanet J Rare Dis,2015,10:71.
[33] MONACO S E,RODRIGUEZ E F,MAHAFFEY A L,et al.FGFR1 amplification in squamous cell carcinoma of the lung with correlation of primary and metastatic tumor status[J].Am J Clin Pathol,2016,145(1):55-61.
[34] KATOH M,NAKAGAMA H.FGF receptors:cancer biology and therapeutics[J].Med Res Rev,2014,34(2):280-300.
[35] BUNNEY T D,WAN S,THIYAGARAJAN N,et al.The effect of mutations on drug sensitivity and kinase activity of fibroblast growth factor receptors:a combined experimental and theoretical study[J].E Bio Med,2015,2(3):194-204.