[1]李嵩箕.黏附分子接触蛋白-1调控神经炎症参与神经精神疾病研究进展[J].新乡医学院学报,2024,(3):201-203.[doi:10.7683/xxyxyxb.2024.03.001]
 LI Songji.Research progress on the involvement of adhesion molecule contactin-1 in neuropsychiatric disorders by regulating neuroinflammation[J].Journal of Xinxiang Medical University,2024,(3):201-203.[doi:10.7683/xxyxyxb.2024.03.001]
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黏附分子接触蛋白-1调控神经炎症参与神经精神疾病研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年3
页码:
201-203
栏目:
国家自然科学基金专题述评
出版日期:
2024-03-05

文章信息/Info

Title:
Research progress on the involvement of adhesion molecule contactin-1 in neuropsychiatric disorders by regulating neuroinflammation
作者:
李嵩箕12
(1.河南省无创性神经调制国际联合实验室,河南 新乡 453003;2.新乡医学院基础医学院生理学与病理生理学系,河南 新乡 453003 )
Author(s):
LI Songji12
(1.International Joint Lab for Non-invasive Neural Modulation of Henan Province,Xinxiang 453003,Henan Province,China;2.Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
接触蛋白-1炎症胶质细胞抑郁症认知障碍
Keywords:
contactin-1inflammationglial celldepressioncognitive dysfunction
分类号:
R74
DOI:
10.7683/xxyxyxb.2024.03.001
文献标志码:
A
摘要:
接触蛋白-1 (CNTN1)属于神经细胞黏附分子之一,是免疫球蛋白超家族的一个亚组,其通过糖基磷脂酰肌醇锚定的神经元膜蛋白锚定在细胞表面,参与轴突导向、突触形成以及多种神经系统生长、发育和疾病的发生过程。此外,CNTN1可通过多种机制促进炎症反应以及小胶质细胞和星形胶质细胞之间的信号交流,从而参与多种神经、精神疾病的病理过程。本文就CNTN1在抑郁症和认知功能障碍中的作用进行阐述。
Abstract:
Contactin-1 (CNTN1) is a neural cell adhesion molecule belonging to the subgroup of immunoglobulin superfamily.It is anchored on the cell surface through glycosyl phosphatidyl inositol-anchored neural membrane proteins and participates in axon guidance,synapse formation,growth and development of nervous systems,and occurrence of related diseases.In addition,CNTN1 can promote inflammatory response and signal communication between microglia and astrocytes through various mechanisms,playing a role in the pathological processes of various neurological and psychiatric disorders.This article discusses the role of CNTN1 in depression and cognitive dysfunction.

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更新日期/Last Update: 2024-03-05