[1]阎婷婷,赵英政,易宪文,等.氧化应激及炎症对糖尿病肾病的影响[J].新乡医学院学报,2019,36(8):701-705.[doi:10.7683/xxyxyxb.2019.08.001]
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氧化应激及炎症对糖尿病肾病的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年8
页码:
701-705
栏目:
国家自然科学基金专题述评
出版日期:
2019-08-05

文章信息/Info

作者:
阎婷婷12赵英政1易宪文1徐光翠1
(1.新乡医学院公共卫生学院毒理学教研室,河南 新乡 453003;2.南阳市第二人民医院,河南 南阳 473200)
关键词:
氧化应激硫辛酸线粒体损伤炎症糖尿病糖尿病肾病活性氧
分类号:
R587.2
DOI:
10.7683/xxyxyxb.2019.08.001
文献标志码:
A
摘要:
氧化应激及炎症是糖尿病肾病(DN)发生和进展的决定因素,糖尿病患者持续高血糖会损伤线粒体功能,增加活性氧(ROS)产生,激活炎症介质,并抑制抗氧化防御机制,最终导致氧化应激,引起DN。线粒体损伤、ROS增多和炎症反应相互促进,是导致DN发生和病情进展的重要因素。硫辛酸是在线粒体内合成的强抗氧化剂,其能通过抗氧化途径保护线粒体免受损伤。本文就氧化应激、线粒体损伤及炎症反应在DN损伤中的机制及抗氧化剂硫辛酸对DN的保护作用进行综述,旨在为DN的防治提供新思路。

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更新日期/Last Update: 2019-08-05