参考文献/References:
[1] 国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2020:157-158.
CHINESE PHARMACOPOEIA COMMISSION.Pharmacopoeia of the people′s republic of China:VolⅠ[M].Beijing:China Medical Science Press,2020:157-158.
[2] 吴振华.中药红花研究进展的概述[J].世界最新医学信息文摘,2019,19(34):33-34.
WU Z H.Research progress summary of Chinese medicine safflower[J].World Latest Med Infom,2019,19(34):33-34.
[3] 陈梦,赵丕文,孙艳玲,等.红花及其主要成分的药理作用研究进展[J].环球中医药,2012,5(7):556-560.
CHEN M,ZHAO P W,SUN Y L,et al.Advances in pharmacological function of Carthamus tinctorius and its essential constitutes[J].Glob Tradit Chin Med,2012,5(7):556-560.
[4] OBARA H,ONODERA J I.Structure of carthamin[J].Chem Lett,1979,8(2):201-204.
[5] KAZUMA K,TAKAHASHI T,SATO K,et al.Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L[J].Biosci Biotechnol Biochem,2000,64(8):1588-1599.
[6] 武永刚,李雪莹,王苏丽,等.红花黄色素化学成分及对心脑血管作用研究进展[J].齐鲁药事,2011,30(8):481-484.
WU Y G,LI X Y,WANG S L,et al.Research progress on chemical composition and the effects of cardiovascular and cerebral vessels of safflower yellow[J].Qilu Pharm Aff,2011,30(8):481-484.
[7] MESELHY M R,KADOTA S,MOMOSE Y,et al.Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine[J].Chem Pharm Bull,1993,41(10):1796-1802.
[8] YUE S,TANG Y,XU C,et al.Two new quinochalcone C-glycosides from the florets of Carthamus tinctorius[J].Int J Mol Sci,2014,15(9):16760-16771.
[9] TAKAHASHI Y,MIYASAKA N,TASAKA S,et al.Constitution of two coloring matters in the flower petals of Carthamus[J].Tetrahedron Lett,1982,23(49):5163-5166.
[10] SATO S,OBARA H,ONODERA J I,et al.Synthesis of model compounds of safflomin C[J].Bull Chem Soc Jpn,1992,65(2):452-457.
[11] YIN H B,HE Z S,YE Y.Cartorimine,a new cycloheptenone oxide derivative from Carthamus tinctorius[J].J Nat Prod,2000,63(8):1164-1165.
[12] LI F,HE Z,YE Y.Isocartormin,a novel quinochalcone C-glycoside from Carthamus tinctorius[J].Acta Pharm Sin B,2017,7(4):527-531.
[13] JIANG J S,HE J,FENG Z M,et al.Two new quinochalcones from the florets of Carthamus tinctorius[J].Org Lett,2010,12(6):1196-1199.
[14] 杨胜华,陈惠贞,熊新科.四种中成药中红花的薄层层析鉴别[J].中药材,1994,17(4):21-22.
YANG S H,CHEN H Z,XIONG X K.Identification of Carthamus tinctorius in four Chinese patent medicines by TLC[J].J Chin Med Mater,1994,17(4):21-22.
[15] 赫军,陈钟,杨桠楠,等.红花水提取物的化学成分研究[J].中国药学杂志,2014,49(6):455-458.
HE J,CHEN Z,YANG Y N,et al.Chemical constituents from aqueous extract of Carthamus tinctorius[J].Chin Pharm J,2014,49(6):455-458.
[16] 施峰.红花黄酮类成分提取分离及其质量分析研究[D].武汉:湖北中医学院,2007.
SHI F.Study on the abstraction and the quality analysis of the flavonoids in Carthamus tinctorius L.[D].Wuhan:Hubei University of Chinese Medicine,2007.
[17] 范莉,赵海誉,濮润,等.红花的黄酮类化学成分研究[J].中国药学杂志,2011,46(5):333-337.
FAN L,ZHAO H Y,PU R,et al.Study on flavonoids in the flower of Carthamus tinctorius L[J].Chin Pharm J,2011,46(5):333-337.
[18] SAKAMURA S,TERAYAMA Y,KAWAKATSU S,et al.Conjugated serotonins related to cathartic activity in safflower seeds (Carthamus tinctorius L.)[J].Agric Biol Chem,1978,42(9):1805-1806.
[19] ZHANG H L,NAGATSU A,WATANABE T,et al.Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) oil cake[J].Chem Pharm Bull,1997,45(12):1910-1914.
[20] SATO H,KAWAGISHI H,NISHIMURA T,et al.Serotobenine,a novel phenolic amide from safflower seeds (Carthamus tinctorius L.)[J].Agricultural and Biological Chemistry,1985,49(10):2969-2974.
[21] 尹宏斌,何直升,叶阳.红花化学成分的研究[J].中草药,2001,32(9):776-778.
YIN H B,HE Z S,YE Y.Studies on chemical constituents of Carthamus tinctorius[J].Chin Tradit Herb Drugs,2001,32(9):776-778.
[22] 姜建双,夏鹏飞,冯子明,等.红花化学成分研究[J].中国中药杂志,2008,33(24):2911-2913.
JIANG J S,XIA P F,FENG Z M,et al.Chemical constituents from flowers of Carthamus tinctorius[J].China J Chin Mater Med,2008,33(24):2911-2913.
[23] 赫军,李福双,刘照振,等.红花中的多烯炔类化学成分[C]//2010年中国药学大会暨第十届中国药师周论文集.天津,2010:2122-2130.
HE J,LI F S,LIU Z Z,et al.Polyacetylenes from the florets of Carthamus tinctorius[C]//Chinese Pharmaceutical Association,Tianjin Municipal People′s Government.Proceedings of the 2010 Chinese Pharmaceutical Congress and the 10th Chinese Pharmacists Week.Tianjin,2010:2122-2130.
[24] ZHOU Y Z,MA H Y,CHEN H,et al.New acetylenic glucosides from Carthamus tinctorius[J].Chem Pharm Bull,2006,54(10):1455-1456.
[25] TAKII T,HAYASHI M,HIROMA H,et al.Serotonin derivative,N-(p-Coumaroyl)serotonin,isolated from safflower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibroblasts in synergy with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF)[J].J Biochem,1999,125(5):910-915.
[26] YOO H H,PARK J H,KWON S W.An anti-estrogenic lignan glycoside,tracheloside,from seeds of Carthamus tinctorius[J].Biosci Biotechnol Biochem,2006,70(11):2783-2785.
[27] NAGATSU A,ZHANG H L,WATANABE T,et al.New steroid and matairesinol glycosides from safflower (Carthamus tinctorius L.) oil cake[J].Chem Pharm Bull,1998,46(6):1044-1047.
[28] 任瑞涛,李云涛,吴志军,等.HPLC法测定安宫牛黄栓中体外培育牛黄含量[J].生物技术世界,2012,10(10):21.
REN R T,LI Y T,WU Z J,et al.Determination of in vitro cultivated Niuhuang in Angong Niuhuang by HPLC[J].Biotech World,2012,10(10):21.
[29] PALTER R,HADDON W F,LUNDIN R E.The complete structure of matairesinol monoglucoside[J].Phytochemistry,1971,10(7):1587-1589.
[30] PALTER R,LUNDIN R E,HADDON W F.A cathartic lignan glycoside isolated from Carthamus tinctorus[J].Phytochemistry,1972,11(9):2871-2874.
[31] 常海涛,韩宏星,屠鹏飞,等.中药红花化学成分及药理作用[J].国外医药(植物药分册),1999,14(5):201-203.
CHANG H T,HAN H X,TU P F,et al.Chemical constituents and pharmacological effects of Carthamus tinctorius L.[J].For Med(Sect Plant Med),1999,14(5):201-203.
[32] MATTHAUS B,ZCAN M M,AL JUHAIMI F Y.Fatty acid composition and tocopherol profiles of safflower (Carthamus tinctorius L.) seed oils[J].Nat Prod Res,2015,29(2):193-196.
[33] 张戈,郭美丽,李颖,等.红花化学成分研究(Ⅱ)[J].第二军医大学学报,2005,26(2):220-221.
ZHANG G,GUO M L,LI Y,et al.Study on chemical constituents of Flos Carthami(Ⅱ)[J].Acad J Sec Mil Med Univ,2005,26(2):220-221.
[34] 袁茂叶.红花中亚精胺类化合物及其生物活性研究[D].太原:山西大学,2015.
YUAN M Y.Coumaroylspermidines from Carthamus tinctorius L.and their biological activities[D].Taiyuan:Shanxi University,2015.
[35] 陶海荣,高修库,肖吾开提,等.红花籽油中不皂化物成分的分析[J].中国油料作物学报,2000,22(4):40-42.
TAO H R,GAO X K,XIAOWU K T,et al.Analysis of unsaponifia-bles from safflower seed oil[J].Chin J Oil Crop Sci,2000,22(4):40-42.
[36] 王佐梅,肖洪彬,李雪莹,等.中药红花的药理作用及临床应用研究进展[J].中华中医药杂志,2021,36(11):6608-6611.
WANG Z M,XIAO H B,LI X Y,et al.Research progress on pharmacological actions and clinical applications of Carthami Flos[J].China J Tradit Chin Med Pharm,2021,36(11):6608-6611.
[37] 刘发,魏苑,杨新中,等.红花黄素对高血压大鼠的降压作用及对肾素-血管紧张素的影响[J].药学学报,1992,27(10):785-787.
LIU F,WEI Y,YANG X Z,et al.Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin Ⅱ level[J].Acta Pharm,1992,27(10):785-787.
[38] 张团笑,敬华娥,买文丽,等.红花注射液降低家兔动脉血压的机制研究[J].时珍国医国药,2010,21(1):138-139.
ZHANG T X,JING H E,MAI W L,et al.Mechanism of safflower injection in reducing arterial blood pressure in rabbits[J].Lishi-zhen Med Mater Med Res,2010,21(1):138-139.
[39] 李志立,杨冰,翟艳敏,等.基于分子对接技术虚拟筛选红花中抗心肌缺血活性组分[J].中国中药杂志,2020,45(12):2881-2890.
LI Z L,YANG B,ZHAI Y M,et al.Virtual screening of components of safflower against myocardial ischemia based on molecular docking technology[J].China J Chin Mater Med,2020,45(12):2881-2890.
[40] 牛恒立,伏计能,马云海.红花提取物对大鼠心脏缺血再灌注的保护作用及机制研究[J].中国现代应用药学,2019,36(12):1492-1497.
NIU H L,FU J N,MA Y H.Protective effect and mechanism of safflower extract on cardiac ischemia-reperfusion in rats[J].Chin J Mod Appl Pharm,2019,36(12):1492-1497.
[41] XUE X,DENG Y,WANG J,et al.Hydroxysafflor yellow A,a natu-ral compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis[J].Phytomedicine,2021,91:153694.
[42] 崔丽霞,孙丽萍,赵丕文,等.羟基红花黄色素A对氧化应激损伤血管内皮细胞的保护作用研究[J].湖南中医药大学学报,2019,39(4):475-479.
CUI L X,SUN L P,ZHAO P W,et al.Protective mechanism of hydroxysafflor yellow A on vascular endothelial cells injured by oxidative stress[J].J Hunan Univ Chin Med,2019,39(4):475-479.
[43] 梁五林,蔡梦如,崔爽,等.注射用红花黄色素抗心肌缺血和抗凝量效关系研究[J].中南药学,2022,20(6):1322-1328.
LIANG W L,CAI M R,CUI S,et al.Dose-effect relationship between anti-myocardial ischemia and anticoagulation of safflower yellow injection[J].Cent South Pharm,2022,20(6):1322-1328.
[44] 马俊林,朱从飞,刘泽超.红花黄色素注射液辅助治疗非ST段抬高型心肌梗死患者的临床疗效及其对血小板聚集率、血栓弹力图指标的影响[J].实用心脑肺血管病杂志,2021,29(11):92-95.
MA J L,ZHU C F,LIU Z C.Clinical effect of safflower yellow injection in the treatment of patients with non-ST segment elevation myocardial infarction and its impact on platelet aggregation rate and thromboelastogram indexes[J].Pract J Card Cereb Pneumal Vasc Dis,2021,29(11):92-95.
[45] ZHU H,WANG Z,MA C,et al.Neuroprotective effects of hydroxysafflor yellow A:in vivo and in vitro studies[J].Planta Med,2003,69(5):429-433.
[46] 田京伟,傅风华,蒋王林,等.羟基红花黄色素A对脑缺血所致大鼠脑线粒体损伤的保护作用[J].药学学报,2004,39(10):774-777.
TIAN J W,FU F H,JIANG W L,et al.Protective effect of hydroxysafflor yellow A against rat cortex mitochondrial injuries induced by cerebral ischemia[J].Acta Pharm Sin,2004,39(10):774-777.
[47] HOU J,WANG C,ZHANG M,et al.Safflower yellow improves the synaptic structural plasticity by ameliorating the disorder of glutamate circulation in Aβ1-42-induced AD model rats[J].Neurochem Res,2020,45(8):1870-1887.
[48] 金鸣,李金荣,吴伟.红花黄色素抗氧化作用的研究[J].中国中药杂志,2004,29(5):447-449.
JIN M,LI J R,WU W.Study on the antioxidative effect of safflor yellow[J].China J Chin Mater Med,2004,29(5):447-449.
[49] BACCHETTI T,MORRESI C,BELLACHIOMA L,et al.Antioxidant and pro-oxidant properties of Carthamus tinctorius,hydroxy safflor yellow A,and safflor yellow A[J].Antioxidants(Basel),2020,9(2):119.
[50] LI X R,LIU J,PENG C,et al.Polyacetylene glucosides from the florets of Carthamus tinctorius and their anti-inflammatory activity[J].Phytochemistry,2021,187:112770.
[51] 李先燕,朴艺花,宋艺兰,等.羟基红花黄色素A通过AMPK/NF-κB/NLRP3对哮喘小鼠气道炎症的影响[J].时珍国医国药,2022,33(3):594-597.
LI X Y,PIAO Y H,SONG Y L,et al.Effect of hydroxysafflor yellow A on airway inflammation in asthmatic mice through AMPK/NF-κB/NLRP3[J].Lishizhen Med Mater Med Res,2022,33(3):594-597.
[52] 张华敏,刘娜,邓巧娟.羟基红花黄色素A对非酒精性脂肪肝炎细胞的作用[J].中医药导报,2021,27(3):9-12,22.
ZHANG H M,LIU N,DENG Q J.The effect of hydroxysafflor yellow A on non-alcoholic steatohepatitis cells[J].Guid J Tradit Chin Med Pharm,2021,27(3):9-12,22.
[53] LEI H,REN R,SUN Y,et al.Neuroprotective effects of safflower flavonoid extract in 6-hydroxydopamine-induced model of Parkinson′s disease may be related to its anti-inflammatory action[J].Molecules,2020,25(21):5206.
[54] ZHOU H,YANG J,ZHANG C,et al.Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma[J].World J Surg Oncol,2018,16(1):167.
[55] 白皓天,杨婧,李娅兰,等.红花多糖对人肝癌细胞凋亡和自噬的影响及潜在机制[J].中国药房,2022,33(24):2962-2967,2972.
BAI H T,YANG J,LI Y L,et al.Effect and potential mechanism of safflower polysaccharide on apoptosis and autophagy of human hepatocellular carcinoma cells[J].China Pharm,2022,33(24):2962-2967,2972.
[56] 刘超,姬乐,白铁成.红花多糖对胃癌MGC-803细胞增殖和侵袭的影响[J].现代肿瘤医学,2020,28(4):569-573.
LIU C,JI L,BAI T C.Effects of safflower polysaccharide on proliferation and invasion of gastric cancer MGC-803 cells[J].J Mod Oncol,2020,28(4):569-573.
[57] LUO Z,ZENG H,YE Y,et al.Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell[J].Mol Med Rep,2015,11(6):4611-4616.
[58] 龚建明,许小鸯,张选丽,等.羟基红花黄色素A抑制卵巢癌生长及其机制研究[J].中国临床药理学杂志,2020,36(8):971-974.
GONG J M,XU X Y,ZHANG X L,et al.The anti-tumor effect and mechanism of Hydroxysafflor yellow A on ovarian cancer[J].Chin J Clin Pharmacol,2020,36(8):971-974.
[59] ABBASI-MALEKI S,MOUSAVI Z.Hydroethanolic extract of Carthamus tinctorius induces antidepressant-like effects:modulation by dopaminergic and serotonergic systems in tail suspension test in mice[J].Iran J Basic Med Sci,2017,20(9):1063-1073.
[60] CHEN H,MA Y,CHEN M,et al.Safflower extract improves depression in mice by inhibiting the TLR4-NLRP3 inflammation signaling pathway[J].Ann Palliat Med,2021,10(7):8015-8023.
[61] LI S,LI T,JIN Y,et al.Antidepressant-like effects of coumaroylspermidine extract from safflower injection residues[J].Front Pharmacol,2020,11:713.
[62] KIM I,BAE J,KIM B J.Carthami flos regulates gastrointestinal motility functions[J].Integr Med Res,2017,6(4):404-408.
[63] 王月凡,马秀芳,李晓宇,等.红花对小鼠在体小肠平滑肌的作用及治疗习惯性便秘的实验研究[J].广东化工,2019,46(8):40-41.
WANG Y F,MA X F,LI X Y,et al.Effects of safflower on smooth muscle of small intestine in vivo and its treatment for habitual constipation in mice[J].Guangdong Chem Ind,2019,46(8):40-41.
[64] 代书景,石学魁,佟雷,等.红花多糖对肠道微生态失调小鼠肠黏膜sIgA、血浆内毒素和肠道菌群的影响[J].中国微生态学杂志,2022,34(1):12-17.
DAI S J,SHI X K,TONG L,et al.The effect of Carthamus tinctorius polysaccharides on intestinal mucosa sIgA,plasma endotoxin and intestinal flora in mice with intestinal microecological disorders[J].Chin J Microecol,2022,34(1):12-17.
[65] 吕晓梅,卢任玲,马月宏,等.红花对四氯化碳致大鼠急性肝损伤的保护作用及其机制[J].北京中医药大学学报,2018,41(11):943-949.
LYU X M,LU R L,MA Y H,et al.Protective effect of Honghua(Safflower,Flos Carthami) on acute liver injury induced by carbon tetrachloride in rats and mechanism study[J].J Beijing Univ Tradit Chin Med,2018,41(11):943-949.
[66] YAN K,WANG X,PAN H,et al.Safflower yellow and its main component HSYA alleviate diet-induced obesity in mice:possible involvement of the increased antioxidant enzymes in liver and adipose tissue[J].Front Pharmacol,2020,11:482.
[67] 聂园进泽,罗元,李欣洋,等.红花活性成分的提取及其改善皮肤微循环的功效评价[J].日用化学工业,2019,49(5):304-309.
NIE Y J Z,LUO Y,LI X Y,et al.Extraction of active components from Carthamus tinctorius and evaluation of its effect on improving skin microcirculation[J].China Surfactant Deterg Cosmet,2019,49(5):304-309.
[68] JEONG E H,YANG H,KIM J E,et al.Safflower seed oil and its active compound acacetin inhibit UVB-induced skin photoaging[J].J Microbiol Biotechnol,2020,30(10):1567-1573.
[69] 吕培霖,李成义,王俊丽.红花籽油的研究进展[J].中国现代中药,2016,18(3):387-389.
LYU P L,LI C Y,WANG J L.Review of safflower seed oil[J].Mod Chin Med,2016,18(3):387-389.
[70] DA SILVA PREZ E M,DE ALENCAR N M N,DE FIGUEIREDO I S T,et al.Effect of safflower oil (Carthamus tinctorius L.) supplementation in the abdominal adipose tissues and body weight of male Wistar rats undergoing exercise training[J].Food Chem(Oxf),2022,4:100083.
[71] SNOKE D B,ANGELOTTI A,BORKOWSKI K,et al.Linoleate-rich safflower oil diet increases linoleate-derived bioactive lipid mediators in plasma,and brown and white adipose depots of healthy mice[J].Metabolites,2022,12(8):743.
[72] ZHANG Z,LI Q,LIU F,et al.Prevention of diet-induced obesity by safflower oil:insights at the levels of PPARalpha,orexin,and ghrelin gene expression of adipocytes in mice[J].Acta Biochim Biophys Sin(Shanghai),2010,42(3):202-208.
[73] SNOKE D B,MAHLER C A,ANGELOTTI A,et al.Linoleic aci-denriched diet increases mitochondrial tetralinoleoyl cardiolipin,OXPHOS protein levels,and uncoupling in interscapular brown adipose tissue during diet-induced weight gain[J].Biology (Basel),2022,12(1):9.
[74] HONG H,LIM J M,KOTHARI D,et al.Antioxidant properties and diet-related α-glucosidase and lipase inhibitory activities of yogurt supplemented with safflower (Carthamus tinctorius L.) petal extract[J].Food Sci Anim Resour,2021,41(1):122-134.
[75] ADAMSKA I,BIERNACKA P.Bioactive substances in safflower flowers and their applicability in medicine and health-promoting foods[J].Int J Food Sci,2021,2021:6657639.
[76] 徐亮亮,王鹏,王海彬,等.羟基红花黄色素A在制备治疗骨质疏松药物中的应用:CN202010365168.8[P].2020-08-11.
XU L L,WANG P,WANG H B,et al.Application of hydroxysafflor yellow A in preparation of medicine for treating osteoporosis:CN202010365168.8[P].2020-08-11.
[77] RUYVARAN M,ZAMANI A,MOHAMADIAN A,et al.Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity,blood pressure,and insulin resistance in patients with metabolic syndrome:a randomized,double-blind,placebo-controlled clinical trial[J].J Ethnopharmacol,2022,282:114590.
[78] NASIRI K,AKBARI A,NIMROUZI M,et al.Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis,inflammation and oxidative stress[J].J Ethnopharmacol,2021,275:114139.