[1]白启荣,郭姣洁,吴娇.红花的化学成分及药理作用研究进展[J].新乡医学院学报,2024,(1):088-94.[doi:10.7683/xxyxyxb.2024.01.016]
 BAI Qirong,GUO Jiaojie,WU Jiao.Research progress on chemical constituents and pharmacological effects of safflower[J].Journal of Xinxiang Medical University,2024,(1):088-94.[doi:10.7683/xxyxyxb.2024.01.016]
点击复制

红花的化学成分及药理作用研究进展
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年1
页码:
088-94
栏目:
综述
出版日期:
2024-01-05

文章信息/Info

Title:
Research progress on chemical constituents and pharmacological effects of safflower
作者:
白启荣郭姣洁吴娇
(新乡医学院药学院,河南 新乡 453003)
Author(s):
BAI QirongGUO JiaojieWU Jiao
(School of Pharmacy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
红花化学成分药理作用食品保健
Keywords:
safflowerchemical componentspharmacological effectsfood health
分类号:
R285
DOI:
10.7683/xxyxyxb.2024.01.016
文献标志码:
A
摘要:
中药红花临床上主要用于促进血液循环,消除经络阻塞。其有效成分、药理活性和应用开发备受关注,具有广阔的应用前景。红花含有醌氏查尔酮类、黄酮类、生物碱、聚炔类、木脂素、脂肪酸等多种化学成分。现代药理研究表明,红花的多种药理学作用被应用于血管系统、神经系统、免疫系统疾病及抗氧化、抗炎、抗肿瘤等方面。同时,红花籽油具有抗衰老、预防饮食肥胖等作用。本文主要就红花的化学成分、药理作用和食品保健作用等的研究进展进行综述,并概述红花的开发应用前景,以期为红花的进一步研究和开发提供参考。
Abstract:
The traditional Chinese medicine safflower is mainly used to promote blood circulation and eliminate meridians obstruction and its effective ingredients,pharmacological activity and application development have attracted much attention,with broad application prospects.Safflower contains quinone chalcones,flavonoids,alkaloids,polyacetylenes,lignans,fatty acids and other chemical components.Modern pharmacological studies have shown that the various pharmacological effects of safflower have been applied in the vascular system,nervous system,immune system diseases and antioxidant,anti-inflammatory,anti-tumor and other aspects.At the same time,safflower seed oil has the function of anti-aging and preventing dietary obesity.This article mainly reviews the research progress on the chemical composition,pharmacological effects,and food health effects of safflower,and summarize the development and application prospects of safflower,in order to provide reference for further research and development of safflower.

参考文献/References:

[1] 国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2020:157-158.
CHINESE PHARMACOPOEIA COMMISSION.Pharmacopoeia of the people′s republic of China:VolⅠ[M].Beijing:China Medical Science Press,2020:157-158.
[2] 吴振华.中药红花研究进展的概述[J].世界最新医学信息文摘,2019,19(34):33-34.
WU Z H.Research progress summary of Chinese medicine safflower[J].World Latest Med Infom,2019,19(34):33-34.
[3] 陈梦,赵丕文,孙艳玲,等.红花及其主要成分的药理作用研究进展[J].环球中医药,2012,5(7):556-560.
CHEN M,ZHAO P W,SUN Y L,et al.Advances in pharmacological function of Carthamus tinctorius and its essential constitutes[J].Glob Tradit Chin Med,2012,5(7):556-560.
[4] OBARA H,ONODERA J I.Structure of carthamin[J].Chem Lett,1979,8(2):201-204.
[5] KAZUMA K,TAKAHASHI T,SATO K,et al.Quinochalcones and flavonoids from fresh florets in different cultivars of Carthamus tinctorius L[J].Biosci Biotechnol Biochem,2000,64(8):1588-1599.
[6] 武永刚,李雪莹,王苏丽,等.红花黄色素化学成分及对心脑血管作用研究进展[J].齐鲁药事,2011,30(8):481-484.
WU Y G,LI X Y,WANG S L,et al.Research progress on chemical composition and the effects of cardiovascular and cerebral vessels of safflower yellow[J].Qilu Pharm Aff,2011,30(8):481-484.
[7] MESELHY M R,KADOTA S,MOMOSE Y,et al.Two new quinochalcone yellow pigments from Carthamus tinctorius and Ca2+ antagonistic activity of tinctormine[J].Chem Pharm Bull,1993,41(10):1796-1802.
[8] YUE S,TANG Y,XU C,et al.Two new quinochalcone C-glycosides from the florets of Carthamus tinctorius[J].Int J Mol Sci,2014,15(9):16760-16771.
[9] TAKAHASHI Y,MIYASAKA N,TASAKA S,et al.Constitution of two coloring matters in the flower petals of Carthamus[J].
Tetrahedron Lett,
1982,23(49):5163-5166.
[10] SATO S,OBARA H,ONODERA J I,et al.Synthesis of model compounds of safflomin C[J].Bull Chem Soc Jpn,1992,65(2):452-457.
[11] YIN H B,HE Z S,YE Y.Cartorimine,a new cycloheptenone oxide derivative from Carthamus tinctorius[J].J Nat Prod,2000,63(8):1164-1165.
[12] LI F,HE Z,YE Y.Isocartormin,a novel quinochalcone C-glycoside from Carthamus tinctorius[J].Acta Pharm Sin B,2017,7(4):527-531.
[13] JIANG J S,HE J,FENG Z M,et al.Two new quinochalcones from the florets of Carthamus tinctorius[J].Org Lett,2010,12(6):1196-1199.
[14] 杨胜华,陈惠贞,熊新科.四种中成药中红花的薄层层析鉴别[J].中药材,1994,17(4):21-22.
YANG S H,CHEN H Z,XIONG X K.Identification of Carthamus tinctorius in four Chinese patent medicines by TLC[J].J Chin Med Mater,1994,17(4):21-22.
[15] 赫军,陈钟,杨桠楠,等.红花水提取物的化学成分研究[J].中国药学杂志,2014,49(6):455-458.
HE J,CHEN Z,YANG Y N,et al.Chemical constituents from aqueous extract of Carthamus tinctorius[J].Chin Pharm J,2014,49(6):455-458.
[16] 施峰.红花黄酮类成分提取分离及其质量分析研究[D].武汉:湖北中医学院,2007.
SHI F.Study on the abstraction and the quality analysis of the flavonoids in Carthamus tinctorius L.[D].Wuhan:Hubei University of Chinese Medicine,2007.
[17] 范莉,赵海誉,濮润,等.红花的黄酮类化学成分研究[J].中国药学杂志,2011,46(5):333-337.
FAN L,ZHAO H Y,PU R,et al.Study on flavonoids in the flower of Carthamus tinctorius L[J].Chin Pharm J,2011,46(5):333-337.
[18] SAKAMURA S,TERAYAMA Y,KAWAKATSU S,et al.Conjugated serotonins related to cathartic activity in safflower seeds (Carthamus tinctorius L.)[J].Agric Biol Chem,1978,42(9):1805-1806.
[19] ZHANG H L,NAGATSU A,WATANABE T,et al.Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) oil cake[J].Chem Pharm Bull,1997,45(12):1910-1914.
[20] SATO H,KAWAGISHI H,NISHIMURA T,et al.Serotobenine,a novel phenolic amide from safflower seeds (Carthamus tinctorius L.)[J].Agricultural and Biological Chemistry,1985,49(10):2969-2974.
[21] 尹宏斌,何直升,叶阳.红花化学成分的研究[J].中草药,2001,32(9):776-778.
YIN H B,HE Z S,YE Y.Studies on chemical constituents of Carthamus tinctorius[J].Chin Tradit Herb Drugs,2001,32(9):776-778.
[22] 姜建双,夏鹏飞,冯子明,等.红花化学成分研究[J].中国中药杂志,2008,33(24):2911-2913.
JIANG J S,XIA P F,FENG Z M,et al.Chemical constituents from flowers of Carthamus tinctorius[J].China J Chin Mater Med,2008,33(24):2911-2913.
[23] 赫军,李福双,刘照振,等.红花中的多烯炔类化学成分[C]//2010年中国药学大会暨第十届中国药师周论文集.天津,2010:2122-2130.
HE J,LI F S,LIU Z Z,et al.Polyacetylenes from the florets of Carthamus tinctorius[C]//Chinese Pharmaceutical Association,Tianjin Municipal People′s Government.Proceedings of the 2010 Chinese Pharmaceutical Congress and the 10th Chinese Pharmacists Week.Tianjin,2010:2122-2130.
[24] ZHOU Y Z,MA H Y,CHEN H,et al.New acetylenic glucosides from Carthamus tinctorius[J].Chem Pharm Bull,2006,54(10):1455-1456.
[25] TAKII T,HAYASHI M,HIROMA H,et al.Serotonin derivative,N-(p-Coumaroyl)serotonin,isolated from safflower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibroblasts in synergy with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF)[J].J Biochem,1999,125(5):910-915.
[26] YOO H H,PARK J H,KWON S W.An anti-estrogenic lignan glycoside,tracheloside,from seeds of Carthamus tinctorius[J].Biosci Biotechnol Biochem,2006,70(11):2783-2785.
[27] NAGATSU A,ZHANG H L,WATANABE T,et al.New steroid and matairesinol glycosides from safflower (Carthamus tinctorius L.) oil cake[J].Chem Pharm Bull,1998,46(6):1044-1047.
[28] 任瑞涛,李云涛,吴志军,等.HPLC法测定安宫牛黄栓中体外培育牛黄含量[J].生物技术世界,2012,10(10):21.
REN R T,LI Y T,WU Z J,et al.Determination of in vitro cultivated Niuhuang in Angong Niuhuang by HPLC[J].Biotech World,2012,10(10):21.
[29] PALTER R,HADDON W F,LUNDIN R E.The complete structure of matairesinol monoglucoside[J].Phytochemistry,1971,10(7):1587-1589.
[30] PALTER R,LUNDIN R E,HADDON W F.A cathartic lignan glycoside isolated from Carthamus tinctorus[J].Phytochemistry,1972,11(9):2871-2874.
[31] 常海涛,韩宏星,屠鹏飞,等.中药红花化学成分及药理作用[J].国外医药(植物药分册),1999,14(5):201-203.
CHANG H T,HAN H X,TU P F,et al.Chemical constituents and pharmacological effects of Carthamus tinctorius L.[J].For Med(Sect Plant Med),1999,14(5):201-203.
[32] MATTHAUS B,ZCAN M M,AL JUHAIMI F Y.Fatty acid composition and tocopherol profiles of safflower (Carthamus tinctorius L.) seed oils[J].Nat Prod Res,2015,29(2):193-196.
[33] 张戈,郭美丽,李颖,等.红花化学成分研究(Ⅱ)[J].第二军医大学学报,2005,26(2):220-221.
ZHANG G,GUO M L,LI Y,et al.Study on chemical constituents of Flos Carthami(Ⅱ)[J].Acad J Sec Mil Med Univ,2005,26(2):220-221.
[34] 袁茂叶.红花中亚精胺类化合物及其生物活性研究[D].太原:山西大学,2015.
YUAN M Y.Coumaroylspermidines from Carthamus tinctorius L.and their biological activities[D].Taiyuan:Shanxi University,2015.
[35] 陶海荣,高修库,肖吾开提,等.红花籽油中不皂化物成分的分析[J].中国油料作物学报,2000,22(4):40-42.
TAO H R,GAO X K,XIAOWU K T,et al.Analysis of unsaponifia-bles from safflower seed oil[J].Chin J Oil Crop Sci,2000,22(4):40-42.
[36] 王佐梅,肖洪彬,李雪莹,等.中药红花的药理作用及临床应用研究进展[J].中华中医药杂志,2021,36(11):6608-6611.
WANG Z M,XIAO H B,LI X Y,et al.Research progress on pharmacological actions and clinical applications of Carthami Flos[J].China J Tradit Chin Med Pharm,2021,36(11):6608-6611.
[37] 刘发,魏苑,杨新中,等.红花黄素对高血压大鼠的降压作用及对肾素-血管紧张素的影响[J].药学学报,1992,27(10):785-787. 
LIU F,WEI Y,YANG X Z,et al.Hypotensive effects of safflower yellow in spontaneously hypertensive rats and influence on plasma renin activity and angiotensin Ⅱ level[J].Acta Pharm,1992,27(10):785-787.
[38] 张团笑,敬华娥,买文丽,等.红花注射液降低家兔动脉血压的机制研究[J].时珍国医国药,2010,21(1):138-139.
ZHANG T X,JING H E,MAI W L,et al.Mechanism of safflower injection in reducing arterial blood pressure in rabbits[J].Lishi-zhen Med Mater Med Res,2010,21(1):138-139.
[39] 李志立,杨冰,翟艳敏,等.基于分子对接技术虚拟筛选红花中抗心肌缺血活性组分[J].中国中药杂志,2020,45(12):2881-2890.
LI Z L,YANG B,ZHAI Y M,et al.Virtual screening of components of safflower against myocardial ischemia based on molecular docking technology[J].China J Chin Mater Med,2020,45(12):2881-2890.
[40] 牛恒立,伏计能,马云海.红花提取物对大鼠心脏缺血再灌注的保护作用及机制研究[J].中国现代应用药学,2019,36(12):1492-1497.
NIU H L,FU J N,MA Y H.Protective effect and mechanism of safflower extract on cardiac ischemia-reperfusion in rats[J].Chin J Mod Appl Pharm,2019,36(12):1492-1497.
[41] XUE X,DENG Y,WANG J,et al.Hydroxysafflor yellow A,a natu-ral compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis[J].Phytomedicine,2021,91:153694.
[42] 崔丽霞,孙丽萍,赵丕文,等.羟基红花黄色素A对氧化应激损伤血管内皮细胞的保护作用研究[J].湖南中医药大学学报,2019,39(4):475-479.
CUI L X,SUN L P,ZHAO P W,et al.Protective mechanism of hydroxysafflor yellow A on vascular endothelial cells injured by oxidative stress[J].J Hunan Univ Chin Med,2019,39(4):475-479.
[43] 梁五林,蔡梦如,崔爽,等.注射用红花黄色素抗心肌缺血和抗凝量效关系研究[J].中南药学,2022,20(6):1322-1328.
LIANG W L,CAI M R,CUI S,et al.Dose-effect relationship between anti-myocardial ischemia and anticoagulation of safflower yellow injection[J].Cent South Pharm,2022,20(6):1322-1328.
[44] 马俊林,朱从飞,刘泽超.红花黄色素注射液辅助治疗非ST段抬高型心肌梗死患者的临床疗效及其对血小板聚集率、血栓弹力图指标的影响[J].实用心脑肺血管病杂志,2021,29(11):92-95.
MA J L,ZHU C F,LIU Z C.Clinical effect of safflower yellow injection in the treatment of patients with non-ST segment elevation myocardial infarction and its impact on platelet aggregation rate and thromboelastogram indexes[J].Pract J Card Cereb Pneumal Vasc Dis,2021,29(11):92-95.
[45] ZHU H,WANG Z,MA C,et al.Neuroprotective effects of hydroxysafflor yellow A:in vivo and in vitro studies[J].Planta Med,2003,69(5):429-433.
[46] 田京伟,傅风华,蒋王林,等.羟基红花黄色素A对脑缺血所致大鼠脑线粒体损伤的保护作用[J].药学学报,2004,39(10):774-777.
TIAN J W,FU F H,JIANG W L,et al.Protective effect of hydroxysafflor yellow A against rat cortex mitochondrial injuries induced by cerebral ischemia[J].Acta Pharm Sin,2004,39(10):774-777.
[47] HOU J,WANG C,ZHANG M,et al.Safflower yellow improves the synaptic structural plasticity by ameliorating the disorder of glutamate circulation in Aβ1-42-induced AD model rats[J].Neurochem Res,2020,45(8):1870-1887.
[48] 金鸣,李金荣,吴伟.红花黄色素抗氧化作用的研究[J].中国中药杂志,2004,29(5):447-449.
JIN M,LI J R,WU W.Study on the antioxidative effect of safflor yellow[J].China J Chin Mater Med,2004,29(5):447-449.
[49] BACCHETTI T,MORRESI C,BELLACHIOMA L,et al.Antioxidant and pro-oxidant properties of Carthamus tinctorius,hydroxy safflor yellow A,and safflor yellow A[J].Antioxidants(Basel),2020,9(2):119.
[50] LI X R,LIU J,PENG C,et al.Polyacetylene glucosides from the florets of Carthamus tinctorius and their anti-inflammatory activity[J].Phytochemistry,2021,187:112770.
[51] 李先燕,朴艺花,宋艺兰,等.羟基红花黄色素A通过AMPK/NF-κB/NLRP3对哮喘小鼠气道炎症的影响[J].时珍国医国药,2022,33(3):594-597.
LI X Y,PIAO Y H,SONG Y L,et al.Effect of hydroxysafflor yellow A on airway inflammation in asthmatic mice through AMPK/NF-κB/NLRP3[J].Lishizhen Med Mater Med Res,2022,33(3):594-597.
[52] 张华敏,刘娜,邓巧娟.羟基红花黄色素A对非酒精性脂肪肝炎细胞的作用[J].中医药导报,2021,27(3):9-12,22.
ZHANG H M,LIU N,DENG Q J.The effect of hydroxysafflor yellow A on non-alcoholic steatohepatitis cells[J].Guid J Tradit Chin Med Pharm,2021,27(3):9-12,22.
[53] LEI H,REN R,SUN Y,et al.Neuroprotective effects of safflower flavonoid extract in 6-hydroxydopamine-induced model of Parkinson′s disease may be related to its anti-inflammatory action[J].Molecules,2020,25(21):5206.
[54] ZHOU H,YANG J,ZHANG C,et al.Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma[J].World J Surg Oncol,2018,16(1):167.
[55] 白皓天,杨婧,李娅兰,等.红花多糖对人肝癌细胞凋亡和自噬的影响及潜在机制[J].中国药房,2022,33(24):2962-2967,2972.
BAI H T,YANG J,LI Y L,et al.Effect and potential mechanism of safflower polysaccharide on apoptosis and autophagy of human hepatocellular carcinoma cells[J].China Pharm,2022,33(24):2962-2967,2972.
[56] 刘超,姬乐,白铁成.红花多糖对胃癌MGC-803细胞增殖和侵袭的影响[J].现代肿瘤医学,2020,28(4):569-573.
LIU C,JI L,BAI T C.Effects of safflower polysaccharide on proliferation and invasion of gastric cancer MGC-803 cells[J].J Mod Oncol,2020,28(4):569-573.
[57] LUO Z,ZENG H,YE Y,et al.Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell[J].Mol Med Rep,2015,11(6):4611-4616.
[58] 龚建明,许小鸯,张选丽,等.羟基红花黄色素A抑制卵巢癌生长及其机制研究[J].中国临床药理学杂志,2020,36(8):971-974.
GONG J M,XU X Y,ZHANG X L,et al.The anti-tumor effect and mechanism of Hydroxysafflor yellow A on ovarian cancer[J].Chin J Clin Pharmacol,2020,36(8):971-974.
[59] ABBASI-MALEKI S,MOUSAVI Z.Hydroethanolic extract of Carthamus tinctorius induces antidepressant-like effects:modulation by dopaminergic and serotonergic systems in tail suspension test in mice[J].Iran J Basic Med Sci,2017,20(9):1063-1073.
[60] CHEN H,MA Y,CHEN M,et al.Safflower extract improves depression in mice by inhibiting the TLR4-NLRP3 inflammation signaling pathway[J].Ann Palliat Med,2021,10(7):8015-8023.
[61] LI S,LI T,JIN Y,et al.Antidepressant-like effects of coumaroylspermidine extract from safflower injection residues[J].Front Pharmacol,2020,11:713.
[62] KIM I,BAE J,KIM B J.Carthami flos regulates gastrointestinal motility functions[J].Integr Med Res,2017,6(4):404-408.
[63] 王月凡,马秀芳,李晓宇,等.红花对小鼠在体小肠平滑肌的作用及治疗习惯性便秘的实验研究[J].广东化工,2019,46(8):40-41.
WANG Y F,MA X F,LI X Y,et al.Effects of safflower on smooth muscle of small intestine in vivo and its treatment for habitual constipation in mice[J].Guangdong Chem Ind,2019,46(8):40-41.
[64] 代书景,石学魁,佟雷,等.红花多糖对肠道微生态失调小鼠肠黏膜sIgA、血浆内毒素和肠道菌群的影响[J].中国微生态学杂志,2022,34(1):12-17.
DAI S J,SHI X K,TONG L,et al.The effect of Carthamus tinctorius polysaccharides on intestinal mucosa sIgA,plasma endotoxin and intestinal flora in mice with intestinal microecological disorders[J].Chin J Microecol,2022,34(1):12-17.
[65] 吕晓梅,卢任玲,马月宏,等.红花对四氯化碳致大鼠急性肝损伤的保护作用及其机制[J].北京中医药大学学报,2018,41(11):943-949.
LYU X M,LU R L,MA Y H,et al.Protective effect of Honghua(Safflower,Flos Carthami) on acute liver injury induced by carbon tetrachloride in rats and mechanism study[J].J Beijing Univ Tradit Chin Med,2018,41(11):943-949.
[66] YAN K,WANG X,PAN H,et al.Safflower yellow and its main component HSYA alleviate diet-induced obesity in mice:possible involvement of the increased antioxidant enzymes in liver and adipose tissue[J].Front Pharmacol,2020,11:482.
[67] 聂园进泽,罗元,李欣洋,等.红花活性成分的提取及其改善皮肤微循环的功效评价[J].日用化学工业,2019,49(5):304-309.
NIE Y J Z,LUO Y,LI X Y,et al.Extraction of active components from Carthamus tinctorius and evaluation of its effect on improving skin microcirculation[J].China Surfactant Deterg Cosmet,2019,49(5):304-309.
[68] JEONG E H,YANG H,KIM J E,et al.Safflower seed oil and its active compound acacetin inhibit UVB-induced skin photoaging[J].J Microbiol Biotechnol,2020,30(10):1567-1573.
[69] 吕培霖,李成义,王俊丽.红花籽油的研究进展[J].中国现代中药,2016,18(3):387-389.
LYU P L,LI C Y,WANG J L.Review of safflower seed oil[J].Mod Chin Med,2016,18(3):387-389.
[70] DA SILVA PREZ E M,DE ALENCAR N M N,DE FIGUEIREDO I S T,et al.Effect of safflower oil (Carthamus tinctorius L.) supplementation in the abdominal adipose tissues and body weight of male Wistar rats undergoing exercise training[J].Food Chem(Oxf),2022,4:100083.
[71] SNOKE D B,ANGELOTTI A,BORKOWSKI K,et al.Linoleate-rich safflower oil diet increases linoleate-derived bioactive lipid mediators in plasma,and brown and white adipose depots of healthy mice[J].Metabolites,2022,12(8):743.
[72] ZHANG Z,LI Q,LIU F,et al.Prevention of diet-induced obesity by safflower oil:insights at the levels of PPARalpha,orexin,and ghrelin gene expression of adipocytes in mice[J].Acta Biochim Biophys Sin(Shanghai),2010,42(3):202-208.
[73] SNOKE D B,MAHLER C A,ANGELOTTI A,et al.Linoleic aci-denriched diet increases mitochondrial tetralinoleoyl cardiolipin,OXPHOS protein levels,and uncoupling in interscapular brown adipose tissue during diet-induced weight gain[J].Biology (Basel),2022,12(1):9.
[74] HONG H,LIM J M,KOTHARI D,et al.Antioxidant properties and diet-related α-glucosidase and lipase inhibitory activities of yogurt supplemented with safflower (Carthamus tinctorius L.) petal extract[J].Food Sci Anim Resour,2021,41(1):122-134.
[75] ADAMSKA I,BIERNACKA P.Bioactive substances in safflower flowers and their applicability in medicine and health-promoting foods[J].Int J Food Sci,2021,2021:6657639.
[76] 徐亮亮,王鹏,王海彬,等.羟基红花黄色素A在制备治疗骨质疏松药物中的应用:CN202010365168.8[P].2020-08-11.
XU L L,WANG P,WANG H B,et al.Application of hydroxysafflor yellow A in preparation of medicine for treating osteoporosis:CN202010365168.8[P].2020-08-11.
[77] RUYVARAN M,ZAMANI A,MOHAMADIAN A,et al.Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity,blood pressure,and insulin resistance in patients with metabolic syndrome:a randomized,double-blind,placebo-controlled clinical trial[J].J Ethnopharmacol,2022,282:114590.
[78] NASIRI K,AKBARI A,NIMROUZI M,et al.Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis,inflammation and oxidative stress[J].J Ethnopharmacol,2021,275:114139.

相似文献/References:

[1]孙 华,李春燕,薛金涛.葛根的化学成分及药理作用研究进展[J].新乡医学院学报,2019,36(11):1097.[doi:10.7683/xxyxyxb.2019.11.022]
[2]迟宇昊,李 暘,申 远.麦冬化学成分及药理作用研究进展[J].新乡医学院学报,2021,38(2):189.[doi:10.7683/xxyxyxb.2021.02.020]
[3]杜晓妍,吴 娇.茯苓的化学成分和药理作用研究进展[J].新乡医学院学报,2021,38(5):496.[doi:10.7683/xxyxyxb.2021.05.022]
[4]冬海洋,李彦灵,马矜烁,等.中药牛膝叶化学成分分析[J].新乡医学院学报,2020,37(1):012.[doi:10.7683/xxyxyxb.2020.01.004]
 DONG Haiyang,LI Yanling,MA Jinshuo,et al.Analysis of chemical constituents of Achyranthes bidentata leaf[J].Journal of Xinxiang Medical University,2020,37(1):012.[doi:10.7683/xxyxyxb.2020.01.004]
[5]吴 娇,王 聪.黄芪的化学成分及药理作用研究进展[J].新乡医学院学报,2018,35(9):755.[doi:10.7683/xxyxyxb.2018.09.002]
 N/A.N/A[J].Journal of Xinxiang Medical University,2018,35(1):755.[doi:10.7683/xxyxyxb.2018.09.002]
[6]殷田田,白意晓,庄方方,等.高莴苣化学成分研究[J].新乡医学院学报,2016,33(2):091.[doi:10.7683/xxyxyxb.2016.02.003]
 YIN Tian-tian,BAI Yi-xiao,ZHUANG Fang-fang,et al.Chemical constituents of Lactuca elata[J].Journal of Xinxiang Medical University,2016,33(1):091.[doi:10.7683/xxyxyxb.2016.02.003]
[7]曹 轲,丁明明,庄方方,等.中药糙苏中的环烯醚萜类化合物[J].新乡医学院学报,2016,33(3):164.[doi:10.7683/xxyxyxb.2016.03.002]
 CAO Ke,DING Ming-ming,ZHUANG Fang-fang,et al.Iridoid compounds from Phlomis umbrosa of herb medicine[J].Journal of Xinxiang Medical University,2016,33(1):164.[doi:10.7683/xxyxyxb.2016.03.002]
[8]刘军伟,吕洁丽,张来宾.山药地上部分石油醚部位的化学成分研究[J].新乡医学院学报,2016,33(6):457.[doi:10.7683/xxyxyxb.2016.06.003]
 LIU Jun-wei,LYU Jie-li,ZHANG Lai-bin.Chemical constituents of the petroleum ether fraction from the aerial part of Dioscorea opposita[J].Journal of Xinxiang Medical University,2016,33(1):457.[doi:10.7683/xxyxyxb.2016.06.003]
[9]周慧超,贺 爽,宋 宇,等.全缘橐吾根部化学成分及生物活性研究[J].新乡医学院学报,2016,33(12):1017.[doi:10.7683/xxyxyxb.2016.12.001]
 ZHOU Hui-chao,HE Shuang,SONG Yu,et al.Chemical constituents and biological activity of Ligularia mongolica root[J].Journal of Xinxiang Medical University,2016,33(1):1017.[doi:10.7683/xxyxyxb.2016.12.001]
[10]兰宝恒,吴泽青.柴胡的化学成分及药理作用研究进展[J].新乡医学院学报,2023,40(2):174.[doi:10.7683/xxyxyxb.2023.02.015]
 LAN Baoheng,WU Zeqing.Research progress on chemical constituents and pharmacological action of Bupleurum[J].Journal of Xinxiang Medical University,2023,40(1):174.[doi:10.7683/xxyxyxb.2023.02.015]

更新日期/Last Update: 2024-01-05