[1]常宇,胡云峰,苏亚妮,等.长链非编码RNA靶向调控自噬对结直肠癌化学治疗敏感性的影响研究进展[J].新乡医学院学报,2022,39(10):983-987.[doi:10.7683/xxyxyxb.2022.10.016]
　CHANG Yu,HU Yunfeng,SU Yani,et al.Research progress on the effect of long non-coding RNA targeting autophagy in chemotherapy sensitivity of colorectal cancer[J].Journal of Xinxiang Medical University,2022,39(10):983-987.[doi:10.7683/xxyxyxb.2022.10.016]
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长链非编码RNA靶向调控自噬对结直肠癌化学治疗敏感性的影响研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年10
页码:
983-987
栏目:
综述
出版日期:
2022-10-05

文章信息/Info

Title:
Research progress on the effect of long non-coding RNA targeting autophagy in chemotherapy sensitivity of colorectal cancer
作者:
常宇; 胡云峰; 苏亚妮; 侯慧娜
（延安大学附属医院放射治疗科，陕西　延安　716000）
Author(s):
CHANG Yu; HU Yunfeng; SU Yani; HOU Huina
（Department of Radiotherapy,Affiliated Hospital of Yan′an University,Yan′an 716000,Shaanxi Province,China）
关键词:
长链非编码RNA; 自噬; 结直肠癌; 化学治疗敏感性
Keywords:
long non-coding RNA; autophagy; colorectal cancer; chemotherapy sensitivity
分类号:
R735.34
DOI:
10.7683/xxyxyxb.2022.10.016
文献标志码:
A
摘要:
结直肠癌（CRC）是最常见的消化道肿瘤之一，其主要治疗方式包括手术、放射治疗、化学治疗等。CRC对化学治疗药物产生抗性是影响CRC化学治疗疗效的主要因素之一。长链非编码RNA（lncRNA）可在表观遗传水平、转录水平和转录后水平调控基因的表达，其功能的失调与恶性肿瘤的发生、发展密切相关。自噬是一种高度保守的过程，有助于维持适当的癌症微环境，能对饥饿和缺氧等环境变化产生反应，及时清除体内破损的细胞器、损坏的蛋白等有害成分，为机体提供能量。抑制自噬可以增强CRC化学治疗或某些靶向药物的治疗效果。 LncRNA可通过不同机制调控肿瘤细胞的自噬水平。本文就lncRNA调控自噬的机制及其在CRC化学治疗耐药中的作用研究进展进行综述，以期为化学治疗耐药的CRC患者的治疗提供新的治疗策略及潜在治疗靶点。
Abstract:
Colorectal cancer (CRC) is one of the most common digestive tract tumors,and its main treatments include surgery,radiotherapy and chemotherapy.The resistance of CRC to chemotherapy drugs is one of the main factors which affects the efficacy of chemotherapy for CRC.Long non-coding RNA(lncRNAs) can regulate gene expression at epigenetic level,transcription level and post-transcription level,and its dysfunction is closely related to the occurrence and development of malignant tumors.Autophagy is a highly conservative process,which helps to maintain a proper cancer microenvironment,and it can respond to environmental changes such as hunger and hypoxia,remove damaged organelles,damaged proteins and other harmful components in the body in time,and provide energy for the body.Inhibition of autophagy can enhance the therapeutic effect of chemotherapy or some targeted drugs for CRC.LncRNA can regulate the autophagy level of tumor cells through different mechanisms.This article will review the mechanism of lncRNA in regulating autophagy and its role in CRC chemotherapy resistance,in order to provide new therapeutic strategies and potential targets for CRC patients with chemotherapy resistance.

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更新日期/Last Update: 2022-10-05