参考文献/References:
［1］ 李茂军，吴青，陈昌辉，等.“新生儿脑病”比“缺氧缺血性脑病”更合适吗：美国妇产科学会和儿科学会发布的新生儿脑病工作组报告介绍［J］.国际儿科学杂志，2015，42（3）：351-354.
［2］ 邵华，刘炜炜，么鸿雁，等.1990～2010年我国新生儿疾病的疾病负担及变化趋势［J］.疾病监测，2015，30（8）：663-667.
［3］ LONGO M,HANKINS G D.Defining cerebral palsy:pathogenesis,pathophysiology and new intervention［J］.Minerva Ginecol,2009,61 (5):421-429.
［4］ BERSANI I,AURITI C,RONCHETTI M P,et al.Use of early biomarkers in neonatal brain damage and sepsis:state of the art and future perspectives［J］.Biomed Res Int,2015,2015:253520.
［5］ 刘媛，张志刚.泛素羧基末端水解酶-1的研究进展［J］.国际病理科学与临床杂志，2008，28（6）：544-549.
［6］ LIU M C,AKINYI L,SCHARF D,et al.Ubiquitin C-terminal hydr-olase-L1 as a biomarker for ischemic and traumatic brain injury in rats［J］.Eur J Neurosci,2010,31(4):722-732.
［7］ 瞿色华，单连强，董淮富，等.血清UCH-L1蛋白在新生大鼠缺氧缺血性脑病评估中的价值［J］.蚌埠医学院学报，2017，42（11）：1433-1436.
［8］ DOUGLAS-ESCOBAR M,YANG C,BENNETT J,et al.A pilot study of novel biomarkers in neonates with hypoxic-ischemic encephalopathy［J］.Pediatr Res,2010,68(6):531-536.
［9］ DOUGLAS-ESCOBAR M V,HEATON S C,BENNETT J,et al.UCH-L1 and GFAP serum levels in neonates with hypoxic-ischemic encephalopathy:a single center pilot study［J］.Front Neurol,2014,5:273.
［10］ 蒋曙红，王金秀，张一鸣，等.亚低温治疗对缺氧缺血性脑病新生儿血清神经胶质酸性蛋白和泛素羧基末端水解酶L1的影响［J］.中国当代儿科杂志，2014，16（12）：1193-1196.
［11］ 黄玮玲，卢红艳，朱海涛，等.早产儿血清泛素羧基末端水解酶 L1、神经胶质原纤维酸性蛋白与脑损伤的关系［J］.临床儿科杂志，2018，36（1）：44-47.
［12］ LEE T,CHIKKABYRAPPA S M,REFORMINA D,et al.Ubiq-uitin C-terminal hydrolase 1 and phosphorylated axonal neurofilament heavy chain in infants undergoing cardiac surgery:preliminary assessment as potential biomarkers of brain injury［J］.World J Pediatr Congenit Heart Surg,2018,9(4):412-418.
［13］ CHALAK L,LATREMOUILLE S,MIR I,et al.A review of the conundrum of mild hypoxic-ischemic encephalopathy:current challenges and moving forward［J］.Early Hum Dev,2018,120:88-94.
［14］ ENNEN C S,HUISMAN T A,SAVAGE W J,et al.Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling［J］.Am J Obstet Gynecol,2011,205(3):e1-e7.
［15］ MASSARO A N,JEROMIN A,KADOM N,et al.Serum biom-arkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia-a pilot study［J］.Pediatr Crit Care Med,2013,14(3):310-317.
［16］ CHALAK L F,SNCHEZ P J,ADAMS-HUET B,et al.Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy［J］.J Pediatr,2014,164(3):468-474.
［17］ 李振，王丽梅，耿美玉.Tau蛋白与神经细胞死亡［J］.中国临床康复，2006，10（6）：124-126.
［18］ DETERS K D,RISACHER S L,KIM S,et al.Plasma Tau association with brain atrophy in mild cognitive impairment and Alzheimer′s disease［J］.J Alzheimers Dis,2017,58(4):1245-1254.
［19］ HROMADKOVA L,KUPCIK R,JANKOVICOVA B,et al.Difficulties associated with the structural analysis of proteins susceptible to form aggregates:the case of Tau protein as a biomarker of Alzheimer′s disease［J］.J Sep Sci,2016,39(4):799-807.
［20］ FUJII H,TAKAHASHI T,MUKAI T,et al.Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer′s disease:hyperphosphorylation and cleavage of 4- and 3-repeat tau［J］.J Cereb Blood Flow Metab,2017,37(7):2441-2457.
［21］ 康建华，杨立顺，李娜.血浆总tau蛋白和磷酸化tau蛋白在阿尔茨海默病中的诊断意义［J］.国际检验医学杂志，2017，38（1）：37-38.
［22］ 蔡芳芳，温仲民.脑脊液tau蛋白预测轻度认知障碍进展为阿尔茨海默病的Meta分析［J］.中国临床神经科学，2015，23（4）：411-417.
［23］ TAKAHASHI K,HASEGAWA S,MAEBA S,et al.Serum tau protein level serves as a predictive factor for neurological prognosis in neonatal asphyxia［J］.Brain Dev,2014,36(8):670-675.
［24］ SALAMA M,MOHAMED W M.Tau protein as a biomarker for asphyxia:a possible forensic tool［J］.Appl Transl Genom,2016,9:20-22.
［25］ MASSARO A N,WU Y W,BAMMLER T K,et al.Plasma biomarkers of brain injury in neonatal hypoxic-ischemic encephalopathy［J］.J Pediatr,2018,194:67-75.
［26］ 卢雨欣，江雯，林艳，等.血清tau蛋白水平与新生儿缺血缺氧性脑病的严重程度并与神经发育预后相关研究［J］.中国儿童保健杂志，2015，23（11）：1142-1146.
［27］ FLORIO P,GAZZOLO D,LUISI S,et al.Activin A in brain injury［J］.Adv Clin Chem,2007,43:117-130.
［28］ FLORIO P,FRIGIOLA A,BATTISTA R,et al.Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy［J］.Front Biosci (Elite Ed),2010,2(1):36-42.
［29］ FIALA M,BAUMERT M,SURMIAK P,et al.Umbilical markers of perinatal hypoxia［J］.Ginekol Pol,2016,87(3):200-204.
［30］ 李力敏，辛素芳，刘佩，等.脐血tau蛋白、激活素A联合检测对新生儿脑损伤的诊断价值［J］.现代中西医结合杂志，2015，24（14）：1489-1491.
［31］ RISSO F M,SERPERO L D,ZIMMERMANN L J,et al.Urine S100 BB and A1B dimers are valuable predictors of adverse outcome in full-term asphyxiated infants［J］.Acta Paediatr,2013,102(10):e467-e472.
［32］ 王孝勇，张璋.血清S-100蛋白、NSE检测对新生儿缺氧缺血性脑病预后评估的临床价值［J］.临床医药文献电子杂志，2016，3（37）：7317-7318.DOI:10.16281/j.cnki.jocml.2016.37.010.
［33］ SHI L H,ZHOU Y,GUO M F,et al.Serum levels of S-100β correlate with the clinical status and severity of hypoxic-ischemic encephalopathy in neonates［J］.Genet Mol Res,2015,14(4):14760-14771.
［34］ 孟淑英.血清和尿S-100B蛋白对新生儿缺氧缺血性脑病预后的评估价值［J］.中国儿童保健杂志，2013，21（2）：163-165.
［35］ SUN J,LI J,CHENG G,et al.Effects of hypothermia on NSE and S-100 protein levels in CSF in neonates following hypoxic-ischaemic brain damage［J］.Acta Paediatr,2012,101(8):e316-e320.
［36］ 黄玮玲，卢红艳.新生儿脑损伤生物标记物研究进展［J］.中国新生儿科杂志，2016，31（6）：470-473.
［37］ ROKA A,KELEN D,HALASZ J,et al.Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia［J］.Acta Paediatr,2012,101(3):319-323.
［38］ ALSHWEKI A,PE＇REZ-MUN~UZURI A,LO＇PEZ-SUA＇REZ O,et al.Relevance of urinary S100B protein levels as a short-term prognostic biomarker in asphyxiated infants treated with hypothermia［J］.Medicine (Baltimore),2017,96(44):e8453.
［39］ ZAIGHAM M,LUNDBERG F,OLOFSSON P.Protein S100B in umbilical cord blood as a potential biomarker of hypoxic-ischemic encephalopathy in asphyxiated newborn［J］.Early Hum,2017,112:48-53.
［40］ BELLOS I,FITROU G,DASKALAKIS G,et al.Neutrophil gela-tinase-associated lipocalin as predictor of acute kidneyinjury in neonates with perinatal asphyxia:a systematic review and meta-analysis［J］.Eur J Pediatr,2018,117(10):1425-1434.
［41］ TECSON K M,ERHARDTSEN E,ERIKSEN P M,et al.Optimal cut points of plasma and urine neutrophil gelatinase-associated lipocalin for the prediction of acute kidney injury among critically ill adults retrospective determination and clinical validation of a prospective multicentre study［J］.BMJ Open,2017,7(7):e016028.
［42］ HOSNY S S,BEKHET M M,HEBAH H A,et al.Urinary neutrophil gelatinase-associated lipocalin in type 2 diabetes:relation to nephropathy and retinopathy［J］.Diabetes Metab Syndr,2018,12（6）:1019-1024.
［43］ FIALA M,BAUMERT M,SURMIAK P,et al.Umbilical markers of perinatal hypoxia［J］.Ginekol Pol,2016,87(3):200-204.
［44］ KISIEL A,ROSZKOWSKA-BLAIM M,PACZYK-TOMASZEWSKA M,et al.Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates［J］.Cent Eur J Immunol,2017,42(3):274-280.
［45］ 唐静，朱晓玲，张磊.凝溶胶蛋白与相关疾病的关系［J］.现代生物医学进展，2013，13（3）：578-581.
［46］ CHOU S H,LEE P S,KONIGSBERG R G,et al.Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage［J］.Stroke,2011,42(12):3624-3627.
［47］ XU J F,LIU W G,DONG X Q,et al.Change in plasma gelsolin level after traumatic brain injury［J］.J Trauma Acute Care Surg,2012,72(2):491-496.
［48］ YILDIRIM F,GERTZ K,KRONENBERG G,et al.Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury［J］.Exp Neurol,2008,210(2):531-542.
［49］ KOSE M,ELMAS T,GOKAHMETOGLU S,et al.The predictive value of gelsolin for the outcomes of preterm neonates:a pilot study［J］.Pediatr Int,2014,56(6):856-859.
［50］ BENAVENTE-FERNANDEZ I,RAMOS-RODRIGUEZ J J,INFANTE-GARCIA C,et al.Altered plasma-type gelsolin and amyloid-b in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia［J］.J Cereb Blood Flow Metab,2018,39(7):1349-1354.
［51］ LV H，WANG Q，WU S，et al．Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrosponal fluid［J］.Clin Chim Acta,2015,450(2):282-297.
［52］ CELTIK C,ACUNA B,ONER N,et al.Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy［J］.Brain Dev,2004,26(6):398-402.
［53］ 裘艳梅，侯洪涛，叶秀春，等.pH值、乳酸、神经烯醇化酶及泛素羧基末端水解酶L1在早产儿脑损伤中的意义［J］.广东医学，2017，38（6）：885-887.
［54］ KELEN D,ANDORKA C,SZABO＇ M,et al.Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome［J］.PLoS One,2017,12(9):e0184593.
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