[1]梁 活,全雪梅.脚桥核与帕金森病关系研究进展[J].新乡医学院学报,2017,34(9):860-864.[doi:10.7683/xxyxyxb.2017.09.022]
点击复制

脚桥核与帕金森病关系研究进展
分享到:

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年9
页码:
860-864
栏目:
综述
出版日期:
2017-09-05

文章信息/Info

作者:
梁 活全雪梅
(广西壮族自治区江滨医院,广西 南宁 530021)
关键词:
脚桥核帕金森病深部脑刺激
分类号:
R742.5
DOI:
10.7683/xxyxyxb.2017.09.022
文献标志码:
A
摘要:
脚桥核作为中脑运动区及网状激活系统的重要组成部分,与基底神经节等多个部位有密切的纤维联系。脚桥核与帕金森病(PD)患者的步态和姿势调节以及感觉、认知和情感信息整合、睡眠调节有关,在PD的发病中起着重要作用。脚桥核深部脑刺激对PD的运动与非运动症状均有一定疗效,但具体机制尚不明确。为了更好地了解脚桥核在帕金森病的发病及治疗中的作用,本文就脚桥核解剖学、电生理特性及在PD中的病理变化以及脚桥核与PD患者认知障碍、睡眠障碍、运动障碍和PD深部脑刺激治疗的关系进行综述。

参考文献/References:

[1] VITALE F,MATTEI C,CAPOZZO A,et al.Cholinergic excitation from the pedunculopontine tegmental nucleus to the dentate nucleus in the rat[J].Neuroscience,2016,317:12-22.
[2] ARAVAMUTHAN B R,ANGELAKI D E.Vestibular responses in the macaque pedunculopontine nucleus and central mesencephalic reticular formation[J].Neuroscience,2012,223:183-199.
[3] FRAIX V,BASTIN J,DAVID O,et al.Pedunculopontine nucleus area oscillations during stance,stepping and freezing in Parkinson′s disease[J].PLoS One,2013,8(12):e83919.
[4] SEBILLE S B,BELAID H,PHILIPPE A C,et al.Anatomical evidence for functional diversity in the mesencephalic locomotor region of primates[J].Neuro Image,2017,147:66-78.
[5] COLLOMB-CLERC A,WELTER M L.Effects of deep brain stimulation on balance and gait in patients with Parkinson′s disease:a systematic neurophysiological review[J].Neurophysiol Clin,2015,45(4/5):371-388.
[6] PIENAAR I S,ELSON J L,RACCA C,et al.Mitochondrial abnormality associates with type-specific neuronal loss and cell morphology changes in the pedunculopontine nucleus in Parkinson′s disease[J].Am J Pathol,2013,183(6):1826-1840.
[7] ZWEIG R M,JANKEL W R,HEDREEN J C,et al.The pedunculopontine nucleus in Parkinson′s disease[J].Ann Neurol,1989,26(1):41-46.
[8] KARACHI C,GRABLI D,BERNARD F A,et al.Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson′s disease[J].J Clin Invest,2010,120(8):2745-2754.
[9] BOHNEN N I,ALBIN R L.The cholinergic system and Parkinson′s disease[J].Behav Brain Res,2011,221(2):564-573.
[10] BOHNEN N I,MULLER M L,KOTAGAL V,et al.Heterogeneity of cholinergic denervation in Parkinson′s disease without dementia[J].J Cereb Blood Flow Metab,2012,32(8):1609-1617.
[11] RINNE J O,MA S Y,LEE M S,et al.Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson′s disease is related to disability of the patients[J].Parkinsonism Relat Disord,2008,14(7):553-557.
[12] CHUNG K A,LOBB B M,NUTT J G,et al.Effects of a central cholinesterase inhibitor on reducing falls in Parkinson′s disease[J].Neurology,2010,75(14):1263-1269.
[13] DAUTAN D,SOUZA A S,HUERTA-OCAMPO I,et al.Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits[J].Nat Neurosci,2016,19(8):1025-1033.
[14] DAUTAN D,HACIOGLU BAY H,BOLAM J P,et al.Extrinsic sources of cholinergic innervation of the striatal complex:a whole-brain mapping analysis[J].Front Neuroanat,2016,10:1.
[15] PETZOLD A,VALENCIA M,PAL B,et al.Decoding brain state transitions in the pedunculopontine nucleus:cooperative phasic and tonic mechanisms[J].Front Neural Circuits,2015,9:68.
[16] BROOKS P L,PEEVER J H.Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice[J].J Neurosci,2011,31(19):7111-7121.
[17] THEVATHASAN W,POGOSYAN A,HYAM J A,et al.Alpha oscillations in the pedunculopontine nucleus correlate with gait performance in parkinsonism[J].Brain,2012,135(Pt1):148-160.
[18] LAU B,WELTER M L,BELAID H,et al.The integrative role of the pedunculopontine nucleus in human gait[J].Brain,2015,138(Pt5):1284-1296.
[19] LI M,ZHOU M,WEN P,et al.The network of causal interactions for beta oscillations in the pedunculopontine nucleus,primary motor cortex,and subthalamic nucleus of walking parkinsonian rats[J].Exp Neurol,2016,282:27-36.
[20] BOUCETTA S,CISSE Y,MAINVILLE L,et al.Discharge profiles across the sleep-waking cycle of identified cholinergic,GABA ergic,and glutamatergic neurons in the pontomesencephalic tegmentum of the rat[J].J Neurosci,2014,34(13):4708-4727.
[21] GARCIA-RILL E,KEZUNOVIC N,D′ONOFRIO S,et al.Gamma band activity in the RAS-intracellular mechanisms[J].Exp Brain Res,2014,232(5):1509-1522.
[22] URBANO F J,D′ONOFRIO S M,LUSTER B R,et al.Pedunculopontine nucleus gamma band activity-preconscious awareness,waking,and rem sleep[J].Front Neurol,2014,5:210.
[23] KEZUNOVIC N,URBANO F J,SIMON C,et al.Mechanism behind gamma band activity in the pedunculopontine nucleus[J].Eur J Neurosci,2011,34(3):404-415.
[24] NOSKO D,FERRAYE M U,FRAIX V,et al.Low-frequency versus high-frequency stimulation of the pedunculopontine nucleus area in Parkinson′s disease:a randomised controlled trial[J].J Neurol Neurosurg Psychiatry,2015,86(6):674-679.
[25] AMBONI M,BARONE P,HAUSDORFF J M.Cognitive contributions to gait and falls:evidence and implications[J].Mov Disord,2013,28(11):1520-1533.
[26] ALESSANDRO S,CERAVOLO R,BRUSA L,et al.Non-motor functions in parkinsonian patients implanted in the pedunculopontine nucleus:focus on sleep and cognitive domains[J].J Neurol Sci,2010,289(1/2):44-48.
[27] PETERSON D S,FLING B W,MANCINI M,et al.Dual-task interference and brain structural connectivity in people with Parkinson′s disease who freeze[J].J Neurol Neurosurg Psychiatry,2015,86(7):786-792.
[28] STEFANI A,PEPPE A,GALATI S,et al.The serendipity case of the pedunculopontine nucleus low-frequency brain stimulation:chasing a gait response,finding sleep,and cognition improvement[J].Front Neurol,2013,4:68.
[29] CERAVOLO R,BRUSA L,GALATI S,et al.Low frequency stimulation of the nucleus tegmenti pedunculopontini increases cortical metabolism in Parkinsonian patients[J].Eur J Neurol,2011,18(6):842-849.
[30] DATTA S,O′MALLEY M W,PATTERSON E H.Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulness[J].J Neurosci,2011,31(47):17007-17016.
[31] PERUSSE A D,TURCOTTE I,ST-JEAN G,et al.Types of primary insomnia:is hyperarousal also present during napping[J].J Clin Sleep Med,2013,9(12):1273-1280.
[32] BERDYYEVA T,OTTE S,ALUISIO L,et al.Zolpidem reduces hippocampal neuronal activity in freely behaving mice:a large scale calcium imaging study with miniaturized fluorescence microscope[J].PLoS One,2014,9(11):e112068.
[33] KRENZER M,ANACLET C,VETRIVELAN R,et al.Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia[J].PLoS One,2011,6(10):e24998.
[34] MARTINEZ-GONZALEZ C,BOLAM J P,MENA-SEGOVIA J.Topographical organization of the pedunculopontine nucleus[J].Front Neuroanat,2011,5:22.
[35] TAKAKUSAKI K,CHIBA R,NOZU T,et al.Brainstem control of locomotion and muscle tone with special reference to the role of the mesopontine tegmentum and medullary reticulospinal systems[J].J Neural Transm (Vienna),2016,123(7):695-729.
[36] TATTERSALL T L,STRATTON P G,COYNE T J,et al.Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus[J].Nat Neurosci,2014,17(3):449-454.
[37] WANG M,JIANG S,YUAN Y,et al.Alterations of functional and structural connectivity of freezing of gait in Parkinson′s disease[J].J Neurol,2016,263(8):1583-1592.
[38] YOUN J,LEE J M,KWON H,et al.Alterations of mean diffusivity of pedunculopontine nucleus pathway in Parkinson′s disease patients with freezing of gait[J].Parkinsonism Relat Disord,2015,21(1):12-17.
[39] FISCHER J,SCHWIECKER K,BITTNER V,et al.Modulation of attentional processing by deep brain stimulation of the pedunculopontine nucleus region in patients with parkinsonian disorders[J].Neuropsychology,2015,29(4):632-637.
[40] GOLESTANIRAD L,ELAHI B,GRAHAM S J,et al.Efficacy and safety of pedunculopontine nuclei (ppn) deep brain stimulation in the treatment of gait disorders:a meta-analysis of clinical studies[J].Can J Neurol Sci,2016,43(1):120-126.
[41] WEN P,LI M,XIAO H,et al.Low-frequency stimulation of the pedunculopontine nucleus affects gait and the neurotransmitter level in the ventrolateral thalamic nucleus in 6-OHDA Parkinsonian rats[J].Neurosci Lett,2015,600:62-68.
[42] BALLANGER B,LOZANO A M,MORO E,et al.Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson′s disease:a [(15)O]H2O PET study[J].Hum Brain Mapp,2009,30(12):3901-3909.
[43] WEISS P H,HERZOG J,POTTER-NERGER M,et al.Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers[J].Mov Disord,2015,30(8):1121-1125.
[44] COLNAT-COULBOIS S,GAUCHARD G C,MAILLARD L,et al.Management of postural sensory conflict and dynamic balance control in late-stage Parkinson′s disease[J].Neuroscience,2011,193:363-369.
[45] HONG S,HIKOSAKA O.Pedunculopontine tegmental nucleus neurons provide reward,sensorimotor,and alerting signals to midbrain dopamine neurons[J].Neuroscience,2014,282:139-155.
[46] MULLER M L,ALBIN R L,KOTAGAL V,et al.Thalamic cholinergic innervation and postural sensory integration function in Parkinson′s disease[J].Brain,2013,136(Pt11):3282-3289.
[47] YOUSIF N,BHATT H,BAIN P G,et al.The effect of pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception[J].Eur J Neurol,2016,23(3):668-670.
[48] WELTER M L,DEMAIN A,EWENCZYK C,et al.PPNa-DBS for gait and balance disorders in Parkinson′s disease:a double-blind,randomised study[J].J Neurol,2015,262(6):1515-1525.
[49] THEVATHASAN W,COLE M H,GRAEPEL C L,et al.A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation[J].Brain,2012,135(Pt5):1446-1454.
[50] SCHRADER C,SEEHAUS F,CAPELLE H H,et al.Effects of pedunculopontine area and pallidal DBS on gait ignition in Parkinson′s disease[J].Brain Stimul,2013,6(6):856-859.
[51] MESTRE T A,SIDIROPOULOS C,HAMANI C,et al.Long-term double-blinded unilateral pedunculopontine area stimulation in Parkinson′s disease[J].Mov Disord,2016,31(10):1570-1574.
[52] PINTO S,FERRAYE M,ESPESSER R,et al.Stimulation of the pedunculopontine nucleus area in Parkinson′s disease:effects on speech and intelligibility[J].Brain,2014,137(Pt10):2759-2772.

相似文献/References:

[1]马琪林,鲁丛霞,蔡琰,等.帕金森病患者血小板线粒体谷氨酸载体和复合物活性研究 [J].新乡医学院学报,2007,24(02):114.
[2]洪丽,李珂,闫晓海,等.瞬目反射与肛门括约肌肌电图对帕金森病患者病情分期判定的意义[J].新乡医学院学报,2012,29(12):936.
[3]朱丰霞,常海敏,段 瑛,等.人参皂苷 Rg1对帕金森病小鼠黑质中酪氨酸羟化酶及ephrinB2和磷酸化 c-Jun表达的影响[J].新乡医学院学报,2014,31(10):781.[doi:10.7683/xxyxyxb.2014.10.003]
[4]魏家彬,杨 帆,王淑秀.人参皂苷Rg1对1甲基4苯基1,2,3,6四氢吡啶诱导的帕金森病小鼠黑质酪氨酸蛋白激酶A4表达的影响[J].新乡医学院学报,2015,32(05):404.
[5]李 乐,黄志勇,贺文麟.血浆同型半胱氨酸、催乳素水平与帕金森病及帕金森病痴呆相关性分析[J].新乡医学院学报,2015,32(05):438.
[6]宋金辉,王普清,丁旭东,等.节律性视觉刺激对帕金森病患者运动功能及平衡能力的影响[J].新乡医学院学报,2014,31(12):1006.[doi:10.7683/xxyxyxb.2014.12.011]
[7]孙 冰,徐玉英.氧化苦参碱对帕金森小鼠中枢神经系统氧化应激的影响[J].新乡医学院学报,2020,37(6):509.[doi:10.7683/xxyxyxb.2020.06.002]
 SUN Bing,XU Yuying.Effects of oxymatrine on oxidative stress of central nervous system in Parkinson mice[J].Journal of Xinxiang Medical University,2020,37(9):509.[doi:10.7683/xxyxyxb.2020.06.002]
[8]张静怡,邓永宁,张 萌,等.Sirt3基因过表达慢病毒载体的构建及其在人神经母细胞瘤SH-SY5Y细胞中的表达[J].新乡医学院学报,2021,38(1):006.[doi:10.7683/xxyxyxb.2021.01.002]
 ZHANG Jingyi,DENG Yongning,ZHANG Meng,et al.Construction of lentiviral vector with Sirt3 gene overexpression and its expression in human neuroblastoma SH-SY5Y cells[J].Journal of Xinxiang Medical University,2021,38(9):006.[doi:10.7683/xxyxyxb.2021.01.002]
[9]汤丹丹,张 勋,符益纲,等.磁共振波谱在原发性帕金森病治疗效果评估中的应用价值[J].新乡医学院学报,2021,38(8):734.[doi:10.7683/xxyxyxb.2021.08.007]
 TANG Dandan,ZHANG Xun,FU Yigang,et al.Value of magnetic resonance spectroscopy in evaluating the therapeutic effect of primary Parkinson′s disease[J].Journal of Xinxiang Medical University,2021,38(9):734.[doi:10.7683/xxyxyxb.2021.08.007]
[10]赵雪薇,陈珮琪,牛延翔,等.帕金森病的病因及发病机制研究进展[J].新乡医学院学报,2021,38(4):378.[doi:10.7683/xxyxyxb.2021.04.018]

更新日期/Last Update: 2017-09-05