[1]魏占芳,武永萍,马莉莎,等.彩色多普勒超声半定量评分对慢性乙型病毒性肝炎早期肝硬化的诊断价值[J].新乡医学院学报,2017,34(1):047-49.[doi:10.7683/xxyxyxb.2017.01.013]
 WEI Zhan-fang,WU Yong-ping,MA Li-sha,et al.Diagnostic value of color Doppler ultrasound semi-quantitative grading in the diagnosis of early cirrhosis in patients with chronic hepatitis B[J].Journal of Xinxiang Medical University,2017,34(1):047-49.[doi:10.7683/xxyxyxb.2017.01.013]
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彩色多普勒超声半定量评分对慢性乙型病毒性肝炎早期肝硬化的诊断价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年1
页码:
047-49
栏目:
临床研究
出版日期:
2017-01-05

文章信息/Info

Title:
Diagnostic value of color Doppler ultrasound semi-quantitative grading in the diagnosis of early cirrhosis in patients with chronic hepatitis B
作者:
魏占芳武永萍马莉莎段凌梅
(张家口市传染病医院功能科,河北 张家口 075000)
Author(s):
WEI Zhan-fangWU Yong-pingMA Li-shaDUAN Ling-mei
(Department of Function,Infectious Hospital of Zhangjiakou City,Zhangjiakou 075000,Hebei Province,China)
关键词:
慢性乙型病毒性肝炎早期肝硬化彩色多普勒超声半定量评分诊断价值
Keywords:
chronic hepatitis Bearly cirrhosiscolor Doppler ultrasound semi-quantitative gradingdiagnostic value
分类号:
R575.1
DOI:
10.7683/xxyxyxb.2017.01.013
文献标志码:
A
摘要:
目的 分析彩色多普勒超声半定量评分对慢性乙型病毒性肝炎早期肝硬化的诊断价值。方法 对2015年3月至2016年3月在张家口市传染病医院行肝组织活检并确诊的70例慢性乙型病毒性肝炎患者的临床资料进行回顾性分析,依据活检病理检查结果分为早期肝硬化组(28例)和非肝硬化组(42例),2组患者均行二维超声肝脏检查,使用彩色多普勒超声对患者肝脏实质回声、边缘形态、表面被膜、脾脏面积、肝静脉清晰度、肝内韧带、胆囊壁等进行检查和半定量评分,观察门静脉内径、血流速及血流量;采集患者清晨空腹肘静脉血,分离血清,采用化学发光法检测血清透明质酸(HA)、Ⅳ型胶原(ⅣC)及层粘连蛋白(LN)水平。结果 早期肝硬化组患者肝实质回声、边缘形态、表面被膜、肝静脉清晰度、脾脏面积、肝内韧带及胆囊壁彩色多普勒超声半定量评分均显著高于非肝硬化组,总评分亦显著高于非肝硬化组(P<0.05);早期肝硬化组患者门静脉内径、血流速、血流量显著高于非肝硬化组(P<0.05);早期肝硬化组患者HA、ⅣC、LN水平显著高于非肝硬化组(P<0.05)。结论 彩色多普勒超声半定量评分对慢性乙型病毒性肝炎具有较高的诊断价值,肝纤维化血清学指标升高可考虑早期肝硬化的可能。
Abstract:
Objective To explore the value of color Doppler ultrasound semi-quantitative grading in the diagnosis of early cirrhosis in patients with chronic hepatitis B.Methods A total of 70 patients with chronic hepatitis confirmed by liver tissue biopsy who were admitted in Infectious Hospital of Zhangjiakou City from March 2015 to March 2016 were included in this study and their clinical data were analysed retrospectively;the patients were divided into the early cirrhosis group (n=28) and non-cirrhosis group (n=42) according to the pathological examination results.The two-dimensional ultrasound was performed for liver examination in the two groups.The color Doppler ultrasound was used to examine the liver parenchyma echo,margin morphology,surface capsule,spleen area,hepatic vein resolution,hepatic internal ligament,and gall bladder wall;and the semi-quantitative grading was performed.The portal vein inner diameter,blood flow velocity,and blood flow volume of patients in the two groups were observed.The morning fasting elbow venous blood was collected,and the serum was separated.The chemiluminiscence was used to detect hyaluronic acid (HA),collagen type Ⅳ(ⅣC),and laminin (LN) levels.Results The semi-quantitative scores of liver parenchyma echo,margin morphology,surface capsule,spleen area,hepatic vein resolution,hepatic internal ligament,and gall bladder wall by the color Doppler ultrasound in the early cirrhosis group were significantly higher than those in the non-cirrhosis group (P<0.05),and the total scores were also significantly higher than those in the non-cirrhosis group (P<0.05).The portal vein inner diameter,blood flow velocity,and blood flow volume of patients in the early cirrhosis group were significantly higher than those in the non-cirrhosis group (P<0.05).HA,ⅣC,and LN levels of patients in the early cirrhosis group were significantly higher than those in the non-cirrhosis group (P<0.05).Conclusion The color Doppler ultrasound semi-quantitative grading has a high value in the diagnosis of chronic hepatitis B,and the elevated serological indicators of liver fibrosis can predict the probability of early liver cirrhosis.

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更新日期/Last Update: 2017-01-05