[1]林凤平,何望安.老年原发性高血压患者记忆障碍及其危险因素分析[J].新乡医学院学报,2016,33(3):212-214.[doi:10.7683/xxyxyxb.2016.03.014]
　LIN Feng-ping,HE Wang-an.Risk factors for memory disorders in elderly patients with primary hypertension[J].Journal of Xinxiang Medical University,2016,33(3):212-214.[doi:10.7683/xxyxyxb.2016.03.014]
点击复制

老年原发性高血压患者记忆障碍及其危险因素分析
分享到：

《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年3
页码:
212-214
栏目:
临床研究
出版日期:
2016-03-05

文章信息/Info

Title:
Risk factors for memory disorders in elderly patients with primary hypertension
作者:
林凤平1; 何望安2
（1.咸宁市中心医院内科，湖北　咸宁　430077；2.华润武钢总医院心血管内科，湖北　武汉　430080）
Author(s):
LIN Feng-ping1; HE Wang-an2
(1.Department of Internal Medicine,Xianning Central Hospital,Xianning 430077,Hubei Province,China;2.Department of Cardioangiology,the Huarun Wugang General Hospital,Wuhan 430080,Hubei Province,China)
关键词:
原发性高血压; 记忆障碍; 简易精神状态检查表; 危险因素
Keywords:
primary hypertension; memory disorder; mini-mental state examination; risk factor
分类号:
R473.71
DOI:
10.7683/xxyxyxb.2016.03.014
文献标志码:
A
摘要:
目的　探讨老年原发性高血压患者记忆障碍及其危险因素。方法　选择2013年1月至2014年12月在咸宁市中心医院接受治疗的老年原发性高血压患者152例为研究对象，采用简易精神状态检查表（MMSE）评估患者的认知功能，采用行为记忆测验法第2版（RBMT-Ⅱ）评定患者的记忆功能，采用Pearson线性相关性检验分析记忆障碍患者收缩压（SBP）、脉压（PP）与MMSE、RBMT-Ⅱ评分的相关性，采用logistic回归分析方法分析高血压患者记忆障碍的危险因素。结果　152例患者中发生记忆障碍80例（观察组），无记忆障碍72例（对照组）。观察组患者定向力、短时记忆评分及总评分显著低于对照组（P<0.05），2组患者即刻记忆、注意力和计算能力、语言能力评分比较差异无统计学意义（P>0.05）。高血压Ⅲ级患者的MMSE评分、RBMT-Ⅱ评分均显著低于高血压Ⅰ、Ⅱ级患者（P<0.05），高血压Ⅱ级患者的RBMT-Ⅱ评分显著低于高血压Ⅰ级患者（P<0.05）。观察组患者SBP、PP与RBMT-Ⅱ评分呈负相关（r=-0.403,-0.348,P<0.05），SBP与MMSE评分呈负相关 （r=-0.224,P<0.05)。Logistic回归分析显示，高SBP和PP水平是老年原发性高血压患者记忆障碍的独立危险因素（P<0.05）。结论　老年原发性高血压患者可出现记忆障碍，患者血压水平越高，记忆障碍越严重；高水平的SBP和PP是老年原发性高血压患者记忆障碍的独立危险因素。
Abstract:
Objective　To study the risk factors for memory disorders in elderly patients with primary hypertension.Methods　A total of 152 elderly patients with primary hypertension were selected from January 2013 to December 2014 in Xianning Central Hospital.The cognitive function of the patients was evaluated by mini-mental state examination(MMSE),the memonic function of the patients was evaluated by the rivermead behavioral memory test second edition(RBMT-Ⅱ).The correlation of systolic blood pressure(SBP),pulse pressure(PP) and MMSE,RBMT-Ⅱ score in patients with memory disorders were analyzed by Pearson linear correlation test.The risk factors of memory disorders in patients with primary hypertension were analyzed by logistic regression analysis.Results　There were 80 patients with memory disorder(observation group) among 152 patients,72 patients without memory disorder(control group).The orientation score,short-term memory score and total score in observation group were significantly lower than those in control group(P<0.05).There was no significant difference in the scores of immediate memory,attention and computational ability,linguistic capacity between the two groups(P>0.05).The MMSE score and RBMT-Ⅱ score in patients with grade Ⅲ hypertension were significantly lower than those in patients with gradeⅠ-Ⅱ hypertension(P<0.05).The RBMT-Ⅱ score in patients with grade Ⅱ hypertension was significantly lower than that in patients with grade Ⅰ hypertension(P<0.05).In observation group,SBP and PP were negatively correlated with RBMT-Ⅱ score(r=-0.403,-0.348,P<0.05),SBP was negatively correlated with MMSE score(r=-0.224,P<0.05).Logistic regression analysis showed that high SBP and PP were independent risk factors for memory disorder in elderly patients with primary hypertension(P<0.05).Conclusion　Memory disorder can occur in the elderly patients with primary hypertension.With the increase of blood pressure,the memory disorder is more serious.High SBP and PP are independent risk factors for memory disorder in elderly patients with primary hypertension.

参考文献/References:

［1］　黄勤洲.高血压Ⅱ、Ⅲ级患者血清同型半胱氨酸的水平变化及关系研究［J］.中国实验诊断学，2015，19（9）：1515-1516.
［2］　王自豪，李素娟，王淑辉，等.老年高血压合并血管性痴呆患者血压变异性分析［J］.中国实用神经疾病杂志，2015，18（2）：79-80.
［3］　赵亚军，李丹，陈长香，等.血压水平与高血压患者记忆功能的相关性［J］.中国老年学杂志，2013，33（10）：2368-2369.
［4］　中国高血压防治指南修订委员会.中国高血压防治指南2010［J］.中华心血管杂志，2011，39（7）：579-616.
［5］　郝智慧，李文杰，崔志杰，等.阿尔茨海默病患者尿甲醛浓度与MMSE的相关性［J］.中国老年学杂志，2011，31（18）：3442-3444.
［6］　王立敏，陈长香，李晶影，等.高血压病人不同病程对记忆功能的影响［J］.现代预防医学，2012，39（16）：4173-4174.
［7］　王建辉，陈长香.高血压患者血压水平与记忆障碍的相关性［J］.中华高血压杂志，2012，20（4）：352-357.
［8］　刘素芳.老年脑血管性痴呆早期记忆障碍的康复训练［J］.中国老年保健医学，2014，12（6）：20-21.
［9］　赵晓军，李丹，陈长香，等.颈动脉供血状况对老年高血压患者记忆功能的影响［J］.中国老年学杂志，2012，32（11）：2358-2359.
［10］　陈洪娜，陈长香，王建辉，等.收缩压水平对高血压患者记忆功能的影响［J］.现代预防医学，2012，39（15）：3892-3893.

相似文献/References:

[1]孙丽娟,徐秀敏,王建周,等.82例高血压患者16项人格特质测验[J].新乡医学院学报,1994,11(03):224.
[2]赵建萍,赵秀娟,武德珍.维拉帕米缓释片与普通片对原发性高血压降压效果比较[J].新乡医学院学报,2001,18(05):371.
[3]杨志平,扈秀丽,王津生.培哚普利与非洛地平逆转原发性高血压左室肥厚的对比研究[J].新乡医学院学报,2002,19(04):332.
[4]成　力,陈文江,姚　峰,等.miRNA-505-3p在原发性高血压发病机制中的作用[J].新乡医学院学报,2018,35(11):965.[doi:10.7683/xxyxyxb.2018.11.005]
　CHENG Li,CHEN Wen-jiang,YAO Feng,et al.Role of miRNA-505-3p in the pathogenesis of essential hypertension[J].Journal of Xinxiang Medical University,2018,35(3):965.[doi:10.7683/xxyxyxb.2018.11.005]
[5]牛丹丹,吕本艳.原发性高血压病患者交感神经和迷走神经张力对静息心率的影响[J].新乡医学院学报,2020,37(5):430.[doi:10.7683/xxyxyxb.2020.05.007]
　NIU Dandan,LYU Benyan.Effects of sympathetic nerve and vagal nerve tension on resting heart rate in patients with essential hypertension[J].Journal of Xinxiang Medical University,2020,37(3):430.[doi:10.7683/xxyxyxb.2020.05.007]
[6]李清红,王晓宇,栗夏莲.2型糖尿病并发原发性高血压患者心脏结构和功能变化[J].新乡医学院学报,2018,35(4):314.[doi:10.7683/xxyxyxb.2018.04.014]
　LI Qing-hong,WANG Xiao-yu,LI Xia-lian.Changes of cardiac structure and function in patients with type 2 diabetes mellitus complicated with essential hypertension[J].Journal of Xinxiang Medical University,2018,35(3):314.[doi:10.7683/xxyxyxb.2018.04.014]

更新日期/Last Update: 2016-03-05