[1]王锦,张海艳.注意缺陷多动障碍患儿血清中去甲肾上腺素和多巴胺水平与病情严重程度的关系[J].新乡医学院学报,2023,40(8):769-773.[doi:10.7683/xxyxyxb.2023.08.013]
　WANG Jin,ZHANG Haiyan.Relationship between serum norepinephrine and dopamine levels and disease severity in children with attention deficit hyperactivity disorder[J].Journal of Xinxiang Medical University,2023,40(8):769-773.[doi:10.7683/xxyxyxb.2023.08.013]
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注意缺陷多动障碍患儿血清中去甲肾上腺素和多巴胺水平与病情严重程度的关系
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年8
页码:
769-773
栏目:
临床研究
出版日期:
2023-08-05

文章信息/Info

Title:
Relationship between serum norepinephrine and dopamine levels and disease severity in children with attention deficit hyperactivity disorder
作者:
王锦1; 张海艳2
(1.西安市精神卫生中心妇女心理卫生一科,陕西　西安　710061;2.西安市精神卫生中心少儿心理科,陕西　西安　710061)
Author(s):
WANG Jin1; ZHANG Haiyan2
(1.Department of Women′s Mental Health,Xi′an Mental Health Center,Xi′an 710061,Shaanxi Province,China;2.Department of Children and Adolescent Psychology,Xi′an Mental Health Center,Xi′an 710061,Shaanxi Province,China）
关键词:
注意缺陷多动障碍; 多巴胺; 去甲肾上腺素; 预测价值
Keywords:
attention deficit hyperactivity disorder; dopamine; norepinephrine; predictive value
分类号:
R749.94
DOI:
10.7683/xxyxyxb.2023.08.013
文献标志码:
A
摘要:
目的　探讨注意缺陷多动障碍（ADHD）儿童血清中多巴胺（DA）、去甲肾上腺素（NE）水平及其与病情严重程度的关系。
方法　选择2019年10月至2021年3月于西安市精神卫生中心就诊的86例ADHD患儿为研究对象（观察组），另选择52例健康儿童作为对照组。收集观察组患儿的临床一般资料；采用酶联免疫吸附法检测2组受试者血清NE、DA水平；根据ADHD父母评定量表评分将观察组患儿分为轻度组、中度组和重度组，分析患儿血清NE、DA水平与病情严重程度的关系；采用多因素logistic回归分析影响患儿病情严重程度的因素；采用受试者操作特征（ROC）曲线下面积（AUC）评估NE、DA对病情严重程度的预测价值。
结果　观察组患儿血清NE、DA水平显著高于对照组（P<0.05）。中度组、重度组患儿血清NE、DA水平显著高于轻度组（P<0.05）,重度组患儿血清NE、DA水平显著高于中度组（P<0.05）。Logistic回归分析结果显示，血清NE、DA、铅水平是影响ADHD患儿病情严重程度的独立因素（P<0.05）。ROC曲线分析结果显示，血清NE、DA及二者联合预测ADHD患儿病情严重程度的AUC分别为0.756、0.727、0.895。
结论　ADHD患儿存在NE、DA水平过高现象，且NE、DA水平与ADHD患儿病情严重程度有关，二者联合检测对ADHD患儿病情严重程度具有一定的预测效能。
Abstract:
Objective　To explore the changes of serum dopamine (DA) and norepinephrine (NE) levels in children with attention deficit hyperactivity disorder(ADHD) and their relationships with the severity of the disease.
Methods　A total of 86 children with ADHD admitted to Xi′an Mental Health Center from October 2019 to March 2021 were selected as the research objects(observation group),and 52 healthy children were selected as the control group.The clinical general data of children in the observation group were collected;the serum NE and DA levels of subjects in the two groups were detected by enzyme-linked immunosorbent assay.The children in the observation group were divided into mild group,moderate group and severe group according to the ADHD rating scale-Ⅳ parent version scores;and the relationship between the serum NE and DA levels and the severity of disease of children in the observation group was analyzed;the factors affecting the severity of disease of children were analyzed by using multivariate logistic regression analysis;the predictive value of serum NE and DA levels for the severity of the disease of children was evaluated by using receiver operating characteristic(ROC）area under the curve(AUC).
Results　The serum NE and DA levels of children in the observation group were significantly higher than those in the control group (P<0.05).The serum NE and DA levels of children in the moderate group and severe group were significantly higher than those in the mild group(P<0.05);the serum NE and DA levels of children in the severe group were significantly higher than those in the moderate group(P<0.05).Logistic regression analysis results showed that the NE,DA,lead levels were independent factors affecting the severity of ADHD children (P<0.05).ROC curve analysis results showed that the AUC of serum NE,DA and their combination in predicting of the severity of ADHD in children were 0.756,0.727,0.895,respectively.
Conclusion　Children with ADHD have high levels of NE and DA,and the levels of NE and DA are related to the severity of the disease in children with ADHD.The combination detection of the two indexes has a certain predictive power for the severity of the disease in children with ADHD.

参考文献/References:

［1］　POSNER J,POLANCZYK G V,SONUGA-BARKE E.Attention-deficit hyperactivity disorder［J］.Lancet,2020,395(10222):450-462.
［2］　FARAONE S V,LARSSON H.Genetics of attention deficit hypera-ctivity disorder［J］.Mol Psychiatry,2019,24(4):562-575.
［3］　ALBAJARA SAENZ A,VILLEMONTEIX T,MASSAT I.Structural and functional neuroimaging in attention-deficit/hyperactivity disorder［J］.Dev Med Child Neurol,2019,61(4):399-405.
［4］　JANGMO A,STALHANDSKE A,CHANG Z,et al.Attention-deficit/hyperactivity disorder,school performance,and effect of medication［J］.J Am Acad Child Adolesc Psychiatry,2019,58(4):423-432.
［5］　LOPEZ-LOPEZ A,POCH-OLIVE M L,LOPEZ-PISON J,et al.Treatment of attention-deficit/hyperactivity disorder in clinical practice.A retrospective study［J］.Medicina,2019,79(1):68-71.
［6］　PARRAGA J L,CALLEJA PEREZ B,LOPEZ-MARTIN S,et al.Attention-deficit/hyperactivity disorder and lifestyle habits in children and adolescents［J］.Actas Esp Psiquiatr,2019,47(4):158-164.
［7］　《中华儿科杂志》编辑委员会,中华医学会儿科学分会神经学组,中华医学会儿科学分会儿童保健学组,等.儿童注意缺陷多动障碍诊疗建议［J］.中华儿科杂志,2006,44(10):758-759.
EDITORIAL COMMITTEE OF THE CHINESE JOURNAL OF PEDIATRICS,NEUROLOGY GROUP OF THE CHINESE MEDICAL PEDIATRICS BRANCH,AND CHILD HEALTH GROUP OF THE CHINESE MEDICAL PEDIATRICS BRANCH,et al.Diagnosis and treatment for attention-deficit/hyperactivity disorder in children［J］.Chin J Pediatr,2006,44(10):758-759.
［8］　CARDO E,BUSTILLO M,SERVERA M.The predictive value of DSM-IV criteria in the diagnosis of attention deficit hyperactivity disorder and its cultural differences［J］.Rev Neurol,2007,44(1):19-22.
［9］　MCGRATH J.ADHD and Covid-19:current roadblocks and future opportunities［J］.Ir J Psychol Med,2020,37(3):204-211.
［10］　WONG H C,ZAMAN R.Neurostimulation in treating ADHD［J］.Psychiatr Danub,2019,31(3):265-275.
［11］　HECHTMAN L.ADHD medication treatment and risk of psychosis［J］.Lancet Psychiatry,2019,6(8):632-633.
［12］　OCHOZKOVA A,MIHALCIKOVA L,YAMAMOTOVA A,et al.ADHD symptoms induced by prenatal methamphetamine exposure［J］.Physiol Res,2019,68(3):347-352.
［13］　DICARLO G E,AGUILAR J I,MATTHIES H J,et al.Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors［J］.J Clin Invest,2019,129(8):3407-3419.
［14］　SIGURDARDOTTIR H L,KRANZ G S,RAMI-MARK C,et al.Association of norepinephrine transporter methylation with in vivo NET expression and hyperactivity-impulsivity symptoms in ADHD measured with PET［J］.Mol Psychiatry,2021,26(3):1009-1018.
［15］　宋宇尘,雷爽,韩新民,等.“安神定志灵”对自发性高血压大鼠行为学及前额叶去甲肾上腺素α2A受体的影响研究［J］.江苏中医药,2019,51(12):85-89.
SONG Y C,LEI S,HAN X M,et al.Effect of "Anshen Dingzhi-ling" on behavior and norepinephrine α2A receptor in prefrontal lobe of spontaneously hypertensive rats［J］.Jiangsu J TCM,2019,51(12):85-89.

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更新日期/Last Update: 2023-08-05