[1]张楠,陶源,李春燕,等.白术的化学成分及药理作用研究进展[J].新乡医学院学报,2023,40(6):579-586.[doi:10.7683/xxyxyxb.2023.06.015]
　ZHANG Nan,TAO Yuan,LI Chunyan,et al.Research progress in chemical constituents and pharmacological effect of Atractylodes macrocephala Koidz．[J].Journal of Xinxiang Medical University,2023,40(6):579-586.[doi:10.7683/xxyxyxb.2023.06.015]
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白术的化学成分及药理作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年6
页码:
579-586
栏目:
综述
出版日期:
2023-06-05

文章信息/Info

Title:
Research progress in chemical constituents and pharmacological effect of Atractylodes macrocephala Koidz．
作者:
张楠1; 陶源1; 李春燕2; 罗彪彪1; 郭超1
(1.新乡医学院药学院，河南　新乡　453003；2.新乡医学院三全学院生物与基础医学实验教学中心，河南　新乡　453003)
Author(s):
ZHANG Nan1; TAO Yuan1; LI Chunyan2; LUO Biaobiao1; GUO Chao1
(1.College of Pharmacy,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.Biological and Basic Medical Experimental Teaching Center,Sanquan College of Xinxiang Medical University,Xinxiang 453003,Henan Province,China)
关键词:
白术; 化学成分; 倍半萜及其内酯; 药理活性
Keywords:
Atractylodes macrocephala Koidz.; chemical component; sesquiterpenes and their lactones; pharmacological activity
分类号:
R932
DOI:
10.7683/xxyxyxb.2023.06.015
文献标志码:
A
摘要:
白术为菊科苍术属植物，以干燥的根茎入药，在我国有悠久的药用历史。白术含有多种化学成分，包括倍半萜及内酯类、黄酮类、苯丙素类、炔烃及其苷类、多糖等。现代药理学研究表明，白术具有抗炎、抗肿瘤、改善胃肠道功能、调节泌尿系统、改善神经功能、改善免疫、兴奋子宫平滑肌、降血脂血糖等药理作用，临床上主要用于胃肠道疾病、肝脏疾病等的治疗，具有良好的开发潜力。本文就白术中单体成分及其药理作用的国内外研究进展进行综述，以期为其进一步开发利用提供参考。
Abstract:
Atractylodes macrocephala Koidz．is a plant of Atractylodes DS.in Asteraceae,which is used as medicine with dry rhizomes,and has a long history of medicinal use in China.Studies have found that Atractylodes macrocephala Koidz.contains a variety of chemical components,including sesquiterpene and their lactones,flavonoids,phenylpropanoids,alkynes and their glycosides,polysaccharides,etc.Modern pharmacological research shows that Atractylodes macrocephala Koidz．has anti-infla-mmatory,anti-tumor,improving gastrointestinal function,regulating urinary system,improving neurological function,improving immunity,stimulating uterine smooth muscle,lowering blood lipids and blood sugar and other pharmacological effects;it is mainly used clinically for gastrointestinal diseases,liver diseases and other aspects,and has good development potential.This article reviews the research progress of monomeric components and their pharmacological effects in Atractylodes macrocephala Koidz．at home and abroad,in order to provide reference for its further development and utilization.

参考文献/References:

［1］　CHEN Z L,CAO W Y,ZHOU G X,et al.A sesquiterpene lactam from Atractylodes macrocephala［J］.Phytochemistry,1997,45(4):765-767.
［2］　DING H Y,LIU M Y,CHANG W L,et al.New Sesquiterpenoids from the rhizomes of Atractylodes macrocephala［J］.Chin Pharm J,2005,57:37-42.
［3］　ZHANG N,LIU C,SUN T M,et al.Two new compounds from Atractylodes macrocephala with neuroprotective activity［J］.J Asian Nat Prod Res,2017,19(1):35-41.
［4］　LI Y,DAI M,PENG D.New bisesquiterpenoid lactone from the wild rhizome of Atractylodes macrocephala Koidz.grown in Qimen［J］.Nat Prod Res,2017,31(20):2381-2386.
［5］　JIN H G,KIM K W,LI J,et al.Anti-inflammatory components isolated from Atractylodes macrocephala in LPS-induced RAW264.7 macrophages and BV2 microglial cells［J］.Appl Biol Chem,2022,65:11-24.
［6］　SI J G,ZHANG H X,YU M,et al.Sesquiterpenoids from the rhizomes of Atractylodes macrocephala and their protection against lipopolysaccharide-induced neuroinflammation in microglia BV-2 cells［J］.J Funct Foods,2021,83:104541.
［7］　HOANG LE S,TRAN M H,LEE J S,et al.Inflammatory inhibitory activity of sesquiterpenoids from Atractylodes macrocephala rhizomes［J］.Chem Pharm Bull (Tokyo),2016,64(5):507-511.
［8］　KITAJIMA J,KAMOSHITA A,ISHIKAWA T,et al.Glycosides of Atractylodes ovata［J］.Chem Pharm Bull (Tokyo),2003,51(9):1106-1108.
［9］　JUNG H H,JIN H K,SUNG G K,et al.Anti-oxidative compounds from the aerial parts of Atractylodes macrocephala Koidzumi［J］.Yakhak Hoeji,2007,51(2):88-95.
［10］　邹辉,杨郴,易美玲,等.白术化学成分分离鉴定［J］.中国实验方剂学杂志,2016,22(17):43-48.
ZOU H,YANG B,YI M L,et al.Chemical constituents of Atractylodis macrocephalae rhizoma［J］.Chin J Exp Trad Med Form,2016,22(17):43-48.
［11］　DONG H,HE L,HUANG M,et al.Anti-inflammatory components isolated from Atractylodes macrocephala Koidz.［J］.Nat Prod Res,2008,22(16):1418-1427.
［12］　杨颖,魏梦昕,伍耀业,等.白术多糖提取分离、化学组成和药理作用的研究进展［J］.中草药,2021,52(2):578-584.
YANG Y,WEI M X,WU Y Y,et al.Research progress on extraction separation,chemical constitution and pharmacological activities of polysaccharide extracted from Atractylodes macrocephala［J］.Chin Trad Herb Drugs,2021,52(2):578-584.
［13］　黄玉燕,丁昕宇,孙伟,等.白术水煎剂外用对致炎小鼠血清TNF-α含量的影响［J］.北京中医药大学学报,2005,28(6):57-58.
HUANG Y Y,DING X Y,SUN W,et al.Effect of Baizhu Decoction used externally on serum content of TNF-α in mice with auricle infection［J］.J Beijing Univ Trad Chin Med,2005,28(6):57-58.
［14］　LI C Q,HE L C,JIN J Q.Atractylenolide I and atractylenolide III inhibit lipopolysaccharide-induced TNF-alpha and NO production in macrophages［J］.Phytother Res,2007,21(4):347-353.
［15］　LI C Q,HE L C,DONG H Y,et al.Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala Koidz.［J］.J Ethnopharmacol,2007,114(2):212-217.
［16］　WANG A,XIAO Z,ZHOU L,et al.The protective effect of atractylenolide I on systemic inflammation in the mouse model of sepsis created by cecal ligation and puncture［J］.Pharm Biol,2016,54(1):146-150.
［17］　AMIN A,HOSSEN M J,FU X Q,et al.Inhibition of the Akt/NF-κB pathway is involved in the anti-gastritis effects of an ethanolic extract of the rhizome of Atractylodes macrocephala［J］.J Ethnopharmacol,2022,293:115251.
［18］　GAO Y,XIN D,LIANG X D,et al.Effect of a combination of Atractylodes macrocephala extract with strychnine on the TLR4/NF-κB/NLRP3 pathway in MH7A cells［J］.Exp Ther Med,2023,25(2):91.
［19］　QIAN X,JIANG Y,LUO Y,et al.The anti-hyperuricemia and anti-inflammatory effects of Atractylodes macrocephala in hyperuricemia and gouty arthritis rat models［J］.Comb Chem High Throughput Screen,2023,26(5):950-964.
［20］　朱庆均,郑广娟,张丹.白术水提物抑瘤作用及其机制研究［J］.山东中医药大学学报,2006,30(1):69-71.
ZHU Q J,ZHENG G J,ZHANG D.Study on antitumor effect and mechanism of extract of largehead atractylodes rhizome［J］.J Shandong Univ Trad Chin Med,2006,30(1):69-71.
［21］　朱超,杨晨,郭晨旭,等.白术对胃癌SGC-7901侧群细胞体外增殖影响［J］.社区医学杂志,2019,17(10):574-578.
ZHU C,YANG C,GUO C X,et al.Effect of Atractylodes macrocephala on the vitro proliferation of the side population of gastric cancer cell line SGC-7901［J］.J Comm Med,2019,17(10):574-578.
［22］　HUANG H L,CHEN C C,YEH C Y,et al.Reactive oxygen species mediation of baizhu-induced apoptosis in human leukemia cells［J］.J Ethnopharmacol,2005,97(1):21-29.
［23］　王翕,刘玉瑛,史天良,等.白术挥发油抗实体瘤的作用研究［J］.中国药物与临床,2002,2(4):239-240.
WANG X,LIU Y Y,SHI T L,et al.Inhibitory activity of volatile oil from Atractylodes macrocephala Koidz.on parenchymatous tumor in mice［J］.Chin Remed Clin,2002,2(4):239-240.
［24］　沈国庆,何法霖,李凤新,等.白术挥发油化学成分及抗肿瘤实验研究［J］.北京中医药大学学报,2009,32(6):413-415.
SHEN G Q,HE F L,LI F X,et al.Chemical compositions and anti-tumor test of volatile oil from Rhizome Atractylodes macrocephala［J］.J Beijing Univ Trad Chin Med,2009,32(6):413-415.
［25］　张宗,张鸿翔,史天良,等.白术挥发油抗肿瘤作用的研究［J］.肿瘤研究与临床,2006,18(12):799-800.
ZHANG Z,ZHANG H X,SHI T L,et al.Research about the antitumor function of Atractylodes macrocephala Koidz.volatile oil［J］.Cancer Res Clin,2006,18(12):799-800.
［26］　赵洪敏,朱庆均,郑广娟,等.白术提取物对人肺癌PG细胞体外侵袭作用的影响［J］.山东中医药大学学报,2005,29(6):465-466,486.
ZHAO H M,ZHU Q J,ZHENG G J,et al.Extract of largehead atractylodes rhizome on external inhibitor invasion of PG cells of human lung cancer［J］.J Shandong Univ TCM,2005,29(6):465-466,486.
［27］　LI X J,LIU F,LI Z,et al.Atractylodes macrocephala polysaccharides induces mitochondrial-mediated apoptosis in glioma C6 cells［J］.Int J Biol Macromol,2014,66:108-112.
［28］　WANG C C,CHEN L G,YANG L L.Cytotoxic activity of sesquite-rpenoids from Atractylodes ovata on leukemia cell lines［J］.Planta Med,2002,68(3):204-208.
［29］　YAN Y,CHOU G X,HUI W,et al.Effects of sesquiterpenes isolated from largehead atractylodes rhizome on growth,migration,and differentiation of B16 melanoma cells［J］.Integr Cancer Ther,2011,10(1):92-100.
［30］　GAO X L,WANG B Y,CHEN Y L,et al.Atractylenolide II significantly reduces proliferation of mouse colon cancer cells［J］.World Chin J Digest,2013,21(26):2690-2693.
［31］　高小玲,汪保英,尹素改,等.白术内酯对IEC-6细胞及食管癌细胞ECA9706增殖能力的影响［J］.中华中医药杂志,2015,30(3):921-923.
GAO X L,WANG B Y,YIN S G,et al.Research of atractylenolide on proliferation ability of IEC-6 cells and esophageal cancer ECA9706 cells［J］.Chin J Trad Chin Med Pharm,2015,30(3):921-923.
［32］　龙方懿,贾萍,王华飞,等.白术内酯 Ⅰ 抑制卵巢癌SK-OV-3与OVCAR-3细胞增殖作用机制的研究［J］.局解手术学杂志,2017,26(2):89-93.
LONG F Y,JIA P,WANG H F,et al.Mechanisms and proliferation inhibitory effects of atractylenolide Ⅰ on SK-OV-3 and OVCAR-3 ovarian cancer cell［J］.J Reg Anat Oper Surg,2017,26(2):89-93.
［33］　张彩霞,张亚杰,江滨,等.白术内酯 Ⅱ 促进大肠癌Lovo细胞凋亡及对PARP1和caspase-3表达的影响［J］.中国实验方剂学杂志,2017,23(5):157-161.
ZHANG C X,ZHANG Y J,JIANG B,et al.Effect of atractylenolide Ⅱ in promoting apoptosis of lovo cells and its impact on expression of PARP1 and caspase-3［J］.Chin J Exp Trad Med Formulae,2017,23(5):157-161.
［34］　朱金照,冷恩仁,桂先勇,等.白术、藿香等中药对胃排空、肠推进影响的实验研究［J］.中国中医基础医学杂志,2000,6(1):24-26.
ZHU J Z,LENG E R,GUI X Y,et al.Experimental study for effects of some Chinese herbals on gastrointestinal motility［J］.Chin J Bas Med TCM,2000,6(1):24-26.
［35］　朱金照,张捷,许其增,等.白术促进大鼠胃肠道运动的机制探讨［J］.中国临床药学杂志,2001,10(6):365-368.
ZHU J Z,ZHANG J,XU Q Z,et al.Mechanisms of Atractylodes macrocephala enhancing gastrointestinal motility［J］.Chin J Clin Pharm,2001,10(6):365-368.
［36］　余平,费莹,李洪玉,等.以离体肠肌抑制作用评价麸炒炮制工艺对白术药效的影响［J］.中华中医药学刊,2017,35(5):1091-1093.
YU P,FEI Y,LI H Y,et al.Effects of Atractylodes with different processing on isolated intestinal muscle［J］.Chin Arch TCM,2017,35(5):1091-1093.
［37］　张奕强,许实波,林永成.白术内酯系列物的胃肠抑制作用［J］.中药材,1999,22(12):636-640.
ZHANG Y Q,XU S B,LIN Y C.Gastrointestinal inhibitory effects of sesquiterpene lactones from Atractylodes macrocephala［J］.J Chin Med Mater,1999,22(12):636-640.
［38］　马晓松，樊雪萍，陈忠，等.白术对动物胃肠运动的作用及其机制的探讨［J］.中华消化杂志,1996,16(5):261-264.
MA X S,FAN X P,CHEN Z,et al.Effects and mechanism of rhizome Atractylodes macrocephala on gastrointestinal motility in animals［J］.Chin J Digest,1996,16(5):261-264.
［39］　李多,杜三军,于永强.白术内酯Ⅰ对慢性萎缩性胃炎大鼠相关炎性因子的影响［J］.解放军医药杂志,2016,28(8):10-14.
LI D,DU S J,YU Y Q.Effect of atractylenolide Ⅰ on related inflammatory factors of rats with chronic atrophic gastritis［J］.Med Pharm J Chin PLA,2016,28(8):10-14.
［40］　WANG K T,CHEN L G,WU C H,et al.Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo［J］.J Pharm Pharmacol,2010,62(3):381-388.
［41］　王洲,李茹柳,徐颂芬,等.白术糖复合物对IEC-6细胞分化及绒毛蛋白表达的影响［J］.中药材,2010,33(6):938-944.
WANG Z,LI R L,XU S F,et al.Effects of Atractylodes macrocephala monosaccharide composition on cytodifferentiation and villin expression of IEC-6 cells in vitro［J］.J Chin Med Mater,2010,33(6):938-944.
［42］　SONG H P,LI R L,CHEN X,et al.Atractylodes macrocephala Koidz.promotes intestinal epithelial restitution via the polyamine--voltage-gated K+ channel pathway［J］.J Ethnopharmacol,2014,152(1):163-172.
［43］　伍婷婷,李茹柳,曾丹,等.白术多糖调控钙离子以促进细胞迁移及E-钙黏蛋白表达的研究［J］.中药新药与临床药理,2017,28(2):145-150.
WU T T,LI R L,ZENG D,et al.Research of Atractylodes macrocephala polysaccharides in promoting cell migration and E-cadherin expression through regulating calcium ions［J］.Trad Chin Drug Res Clin Pharm,2017,28(2):145-150.
［44］　鄢伟伦,王帅帅,任霞.白术对小鼠肠道菌群调节作用的实验研究［J］.山东中医杂志,2011,30(6):417-419.
YAN W L,WANG S S,REN X.Experimental study of atractylodes on intestinal microflora in mice［J］.Shandong J Trad Chin Med,2011,30(6):417-419.
［45］　WANG R,ZHOU G,WANG M,et al.The metabolism of polysaccharide from Atractylodes macrocephala Koidz.and its effect on intestinal microflora［J］.Evid Based Complement Alternat Med,2014,2014:926381.
［46］　刘丽莎,王锐,旭日花,等.白术多糖对益生菌的促生长作用及结构分析［J］.食品科学,2010,31(19):124-128.
LIU L S,WANG R,XU R H,et al.Promoting effect of polysaccharides isolated from Rhizoma Atractylodis macrocephalae on the growth of probiotics and structure analysis［J］.Food Sci,2010,31(19):124-128.
［47］　陈敏珠,张毅.白术的利尿作用［J］.生理学报,1961,24(3):227-237.
CHEN M Z,ZHANG Y.The diuretic action of Atractylodes macrocephala［J］.Acta Physiol Sin,1961,24(3):227-237.
［48］　李继承，吕志连，石元和，等.腹膜孔的药物调节和计算机图像处理［J］.中国医学科学院学报,1996,18(3):219-223.
LI J C,LV Z L,SHI Y H,et al.Study on pharmacological regulation of the peritoneal stomata and its computer image processing［J］.Acta Acad Med Sin,1996,18(3):219-223.
［49］　SATOH K,NAGAI F,USHIYAMA K,et al.Specific inhibition of Na+,K+-ATPase activity by atractylon,a major component of byaku-jutsu,by interaction with enzyme in the E2 state［J］.Biochem Pharmacol,1996,51(3):339-343.
［50］　陈静,孙云超,冉小库,等.白术利尿作用研究［J］.中国现代中药,2016,18(5):563-567.
CHEN J,SUN Y C,RAN X K,et al.Study on diuretic effect of Atractylodis macrocephalae rhizoma［J］.Mod Chin Med,2016,18(5):563-567.
［51］　施文荣,刘艳,陈玲,等.白术燥湿利水作用的研究［J］.福建中医学院学报,2007,17(3):29-31.
SHI W R,LIU Y,CHEN L,et al.Experimental study on the effect of drying dampness and diuresis of Atractylodes macrocephala［J］.J Fujian Coll TCM,2007,17(3):29-31.
［52］　高群.白术对局灶性脑缺血/再灌注大鼠的神经保护作用的研究［J］.医学理论与实践,2017,30(15):2185-2186,2189.
GAO Q.Effect of rhizome Atractylodis macrocephalae on neural functional recovery on cerebral ischemia/reperfusion rat［J］.J Med Theor Prac,2017,30(15):2185-2186,2189.
［53］　高群,于新宇.白术对脑老化小鼠记忆能力和突触结构的影响［J］.菏泽医学专科学校学报,2016,28(2):1-3,14.
GAO Q,YU X Y.Effect of rhizoma Atractylodis macrocephalae on learning-memory and synaptic structure in aging mice［J］.J Heze Med Coll,2016,28(2):1-3,14.
［54］　高群,于新宇.白术对脑老化小鼠认知能力及相关信号蛋白表达的影响［J］.菏泽医学专科学校学报,2016,28(1):1-3,45.
GAO Q,YU X Y.Effect of rhizoma Atractylodis macrocephalae on learning-memory and expression of related signal proteins in hippocampus of brain aging mice［J］.J Heze Med Coll,2016,28(1):1-3,45.
［55］　胡微煦,向勤,付爱珍,等.白术多糖对神经细胞毒性及抗缺氧诱导的神经细胞凋亡的影响［J］.中药药理与临床,2014,30(3):89-91.
HU W X,XIANG Q,FU A Z,et al.Study of Atractylodes macrocephala on polysaccharides on the neuron toxicity and anti-apoptosis induced by hypoxia/reoxygenation［J］.Pharmac Clin Chin Mater Medica,2014,30(3):89-91.
［56］　王光伟,丰昀,邱细敏,等.白术多糖对大鼠创伤性脑损伤后脑水肿的影响及其机制探讨［J］.食品科学,2008,29(6):675-677.
WANG G W,FENG J,QIU X M,et al.Effects of polysaccharide of Atractylodes macrocephala Koidz.on brain edema after traumatic brain injury in rats［J］.Food Sci,2008,29(6):675-677.
［57］　石娜,苏洁,杨正标,等.白术多糖对D-半乳糖致衰老模型小鼠的抗氧化作用［J］.中国新药杂志,2014,23(5):577-581,584.
SHI N,SU J,YANG Z B,et al.Antoxidantive effect of polysaccharides from Atractylodes macrocephala in D-galactose-induced aging mice［J］.Chin J New Drugs,2014,23(5):577-581,584.
［58］　冯星,王正濂,林永成,等.双白术内酯对Aβ1-40致痴呆模型大鼠的作用［J］.中国药理学通报,2009,25(7):949-951.
FENG X,WANG Z L,LIN Y C,et al.Effects of biatractylolide on the AD rats induced by Aβ1-40［J］.Chin Pharm Bull,2009,25(7):949-951.
［59］　刘洋,廖春梅.双白术内酯对三氯化铝致痴呆模型小鼠的作用研究［J］.湖南师范大学学报(医学版),2006,3(3):25-26,30.
LIU Y,LIAO C M.Effects of biatractylolide on the AD rats induced by AlCl3［J］.J Hunan Norm Univ (Med Sci),2006,3(3):25-26,30.
［60］　LIU C,ZHAO H,JI Z H,et al.Neuroprotection of atractylenolide Ⅲ from Atractylodis macrocephalae against glutamate-induced neuronal apoptosis via inhibiting caspase signaling pathway［J］.Neurochem Res,2014,39(9):1753-1758.
［61］　GAO H,ZHU X,XI Y,et al.Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress［J］.Exp Ther Med,2018,15(2):1574-1579.
［62］　孙文平,李发胜,侯殿东,等.当归、白术、制白附子多糖对小鼠免疫调节作用的影响［J］.中国中医药信息杂志,2008,15(7):37-38.
SUN W P,LI F S,HOU D D,et al.Effect of three kinds of polysaccharides from herbal medicines on immunomodulation in mice［J］.Chin J Inform Trad Chin Med,2008,15(7):37-38.
［63］　孙文平,李发胜,陈晨,等.白术多糖对小鼠免疫功能调节的研究［J］.中国微生态学杂志,2011,23(10):881-882,886.
SUN W P,LI F S,CHEN C,et al.Immunomodulation of Atractylodis polysaccharides in mice［J］.Chin J Microecol,2011,23(10):881-883,886.
［64］　相雪莲,许丹宁,曹楠,等.白术多糖对环磷酰胺诱导的免疫抑制小鼠白细胞数量及功能的修复作用［J］.中国兽医杂志,2020,56(7):36-41,32.
XIANG X L,XU D N,CAO N,et al.The repair effect of polysaccharide of Atractylodes macrocephala Koidz.induced by cyclophosphamide on the number and function of white blood cells of immunosuppressive micc［J］.Chin J Veter Med,2020,56(7):36-41,32.
［65］　郭志欣,梁中焕,娄丽秋,等.白术多糖的提取、纯化和活性研究［J］.安徽农业科学,2012,40(24):12011-12013.
GUO Z X,LIANG Z H,LOU L Q,et al.Isolation,purification and activity analysis of polysaccharides from rhizoma Atractylodes macrocephalae［J］.J Anhui Agric Sci,2012,40(24):12011-12013.
［66］　关晓辉,曲娴,杨志萍,等.白术挥发油对小鼠免疫功能的影响［J］.北华大学学报(自然科学版),2001,2(2):122-124.
GUAN X H,QU X,YANG Z P,et al.Effect of Atractylodes macrocephala Koidz.on immune function of mice［J］.J Beihua Univ(Nat Sci）,2001,2(2):122-124.
［67］　冯子芳,唐仕华,郭莉佳,等.白术多糖通过激活免疫细胞抑制小鼠结肠癌HT-29细胞原位移植瘤的生长［J］.中国肿瘤生物治疗杂志,2019,26(11):1209-1213.
FENG Z F,TANG S H,GUO L J,et al.Polysaccharide of Atractylodes macrocephala inhibits the growth of mice in-situ colon cancer HT-29 cell xenograft via activating immune cells［J］.Chin J Cancer Biother,2019,26(11):1209-1213.
［68］　银瑞,王俊钢.白术多糖对肺癌模型大鼠免疫功能的调节作用及机制研究［J］.中国医药生物技术,2019,14(6):527-533.
YIN R,WANG J G.Regulation and mechanism of Atractylodes macrocephala L.polysaccharide on immune function in lung cancer model rats［J］.Chin Med Biotechnol,2019,14(6):527-533.
［69］　QIN M,LIU J,SAKWIWATKUL K,et al.Effect of the extract made from rhizoma Atractylodis macrocephalae (RAM) on the immune responses of mice to a commercial foot-and-mouth disease vaccine［J］.Vet Med Sci,2022,8(5):2067-2075.
［70］　章小莉,汪琳,李家福,等.白术对人妊娠子宫平滑肌收缩活动的影响［J］.武汉大学学报(医学版),2008,29(3):383-386.
ZHANG X L,WANG L,LI J F,et al.Effects of Atractylodes macrocephala on the contraction of human pregnant myometrium［J］.Med J Wuhan Univ,2008,29(3):383-386.
［71］　章小莉,汪琳,徐龙,等.白术对人妊娠子宫平滑肌细胞膜钙依赖钾通道电流的影响［J］.中国妇幼保健,2009,24(3):366-368.
ZHANG X L,WANG L,XU L,et al.Effect of Atractylodes macrocephala on the cytomembrane Ca2+ activated K+ curents in human pregnant myometrium smooth muscle cells［J］.Matern Child Health Care Chin,2009,24(3):366-368.
［72］　单俊杰,田庚元.白术糖复合物AMP-B的理化性质及降血糖活性的研究［J］.药学学报,2003,38(6):438-441.
SHAN J J,TIAN G Y.Studies on physico-chemical properties and hypoglycemic activity of complex polysaccharide AMP-B from Atractylodes macrocephala Koidz.［J］.Acta Pharm Sinic,2003,38(6):438-441.
［73］　李燕,陈素红,吉星,等.白术多糖对自发性2型糖尿病小鼠血糖及相关指标的影响［J］.中国实验方剂学杂志,2015,21(10):162-165.
LI Y,CHEN S H,JI X,et al.Effects of polysaccharide from Atractylodes macrocephala on blood glucose and related indicators in spontaneous type 2 diabetes db/db mice［J］.Chin J Exp Trad Med Formul,2015,21(10):162-165.
［74］　CHAO C L,HUANG H C,LIN H C,et al.Sesquiterpenes from Baizhu stimulate glucose uptake by activating AMPK and PI3K［J］.Am J Chin Med,2016,44(5):963-979.
［75］　彭敏,顾施健,姜淋洁,等.白术提取物降血脂作用的有效部位研究［J］.时珍国医国药,2011,22(10):2363-2365.
PENG M,GU S J,JIANG L J,et al.Antihyperlipidemia active fraction of Atractylodis macrocephalae rhizome extracts［J］.Lishizhen Med Mater Med Res,2011,22(10):2363-2365.
［76］　KIM C K,KIM M,OH S D,et al.Effects of Atractylodes macrocephala Koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity［J］.J Ethnopharmacol,2011,137(1):396-402.
［77］　LI W,ZHI W,LIU F,et al.Atractylenolide I restores HO-1 expression and inhibits Ox-LDL-induced VSMCs proliferation,migration and inflammatory responses in vitro［J］.Exp Cell Res,2017,353(1):26-34.
［78］　JIN C,ZHANG P J,BAO C Q,et al.Protective effects of Atractylodes macrocephala polysaccharide on liver ischemia-reperfusion injury and its possible mechanism in rats［J］.Am J Chin Med,2011,39(3):489-502.
［79］　HWANG J M,TSENG T H,HSIEH Y S,et al.Inhibitory effect of atractylon on tert-butyl hydroperoxide induced DNA damage and hepatic toxicity in rat hepatocytes［J］.Arch Toxicol,1996,70(10):640-644.
［80］　JIANG H,SHI J,LI Y.Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz.［J］.Molecules,2011,16(4):3146-3151.
［81］　ZHU Q,LIN M,ZHUO W,et al.Chemical constituents from the wild Atractylodes macrocephala Koidz.and acetylcholinesterase inhibitory activity evaluation as well as molecular docking study［J］.Molecules,2021,26(23):7299-7305.
［82］　LI X,WEI G,WANG X,et al.Targeting of the Sonic Hedgehog pathway by atractylenolides promotes chondrogenic differentiation of mesenchymal stem cells［J］.Biol Pharm Bull,2012,35(8):1328-1335.
［83］　蒲含林,王正濂,黄巧娟,等.双白术内酯对豚鼠离体心房肌的作用［J］.中国药理学通报,2000,16(1):60-62.
PU H L,WANG Z L,HUANG Q J,et al.Effects of biatractylolide on isolated guinea pig myocardium［J］.Chin Pharmacol Bull,2000,16(1):60-62.
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更新日期/Last Update: 2023-06-05