[1]张璋,孙翠翠,黎晓曦.重度子痫前期患者血清血管内皮生长因子和白细胞介素-4水平与新生儿窒息的相关性[J].新乡医学院学报,2022,39(11):1060-1063.[doi:10.7683/xxyxyxb.2022.11.012]
　ZHANG Zhang,SUN Cuicui,LI Xiaoxi.Correlation between serum vascular endothelial growth factor,interleukin-4 levels and neonatal asphyxia in patients with severe preeclampsia[J].Journal of Xinxiang Medical University,2022,39(11):1060-1063.[doi:10.7683/xxyxyxb.2022.11.012]
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重度子痫前期患者血清血管内皮生长因子和白细胞介素-4水平与新生儿窒息的相关性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
39
期数:
2022年11
页码:
1060-1063
栏目:
临床研究
出版日期:
2022-11-05

文章信息/Info

Title:
Correlation between serum vascular endothelial growth factor,interleukin-4 levels and neonatal asphyxia in patients with severe preeclampsia
作者:
张璋; 孙翠翠; 黎晓曦
（信阳市中心医院妇产科，河南　信阳　464000）
Author(s):
ZHANG Zhang; SUN Cuicui; LI Xiaoxi
(Department of Obstetrics and Gynecology,Xinyang Central Hospital,Xinyang 464000,Henan Province,China)
关键词:
重度子痫前期; 血管内皮生长因子; 白细胞介素4; 新生儿窒息
Keywords:
severe preeclampsia; vascular endothelial growth factor; interleukin-4; neonatal asphyxia
分类号:
R722.12；R714.24+4
DOI:
10.7683/xxyxyxb.2022.11.012
文献标志码:
A
摘要:
目的　探讨重度子痫前期（sPE）患者血清血管内皮生长因子（VEGF）、白细胞介素-4（IL-4）水平与新生儿窒息的相关性。方法　选择2017年1月至2021年1月信阳市中心医院妇产科收治的300例sPE患者作为研究对象，根据是否发生新生儿窒息分为新生儿窒息组（n=19）和非新生儿窒息组（n=281）。于分娩前，采集2组患者的空腹静脉血5 mL，采用酶联免疫吸附法测定血清中VEGF、IL-4水平。采用logistic回归分析血清VEGF、IL-4水平与sPE患者发生新生儿窒息关系。绘制受试者操作特征（ROC）曲线分析血清VEGF、IL-4水平对sPE患者发生新生儿窒息的预测价值。结果　新生儿窒息组患者血清中VEGF、IL-4水平均显著低于非新生儿窒息组（P<0.05）。sPE患者血清VEGF、IL-4水平过表达是新生儿窒息发生的保护因素（P<0.05）。sPE患者血清VEGF、IL-4水平预测新生儿窒息发生的曲线下面积分别为0.889（95%置信区间为0.835~0.943；P<0.001）、0.809（95%置信区间为0.709~0.909；P<0.001），特异度分别为0.842、0.526，灵敏度分别为0.815、 0.954，约登指数分别为0.657、0.480。结论　sPE患者有较高的新生儿窒息发生风险，可能与血清中VEGF、IL-4的异常低表达有关，血清VEGF、IL-4水平对sPE患者发生新生儿窒息有一定的预测价值。
Abstract:
Objective　To investigate the correlation between the levels of serum vascular endothelial growth factor (VEGF),interleukin-4 (IL-4) and neonatal asphyxia in patients with severe preeclampsia (sPE).Methods　A total of 300 sPE patients admitted to the Department of Obstetrics and Gynecology,Xinyang Central Hospital from January 2017 to January 2021 were selected as the research subjects.According to whether neonatal asphyxia occurred,the patients were divided into the neonatal asphyxia group (n=19) and the non-neonatal asphyxia group (n=281).Before delivery,5 mL of fasting venous blood was collected from patients in the two groups,and the levels of VEGF and IL-4 in serum were determined by enzyme-linked immunosorbent assay.The relationship between serum VEGF,IL-4 levels of patients with sPE and neonatal asphyxia was analyzed by logistic regression.The predictive value of serum VEGF and IL-4 levels of patients with sPE on neonatal asphyxia was analyzed by receiver operating characteristic (ROC) curve.Results　The levels of VEGF and IL-4 in serum of patients in the neonatal asphyxia group were significantly lower than those in the non-neonatal asphyxia group (P<0.05).Overexpression of serum VEGF and IL-4 levels were the protective factors for neonatal asphyxia in patients with sPE (P<0.05).The area under curve of serum VEGF and IL-4 levels to predict neonatal asphyxia in sPE patients was 0.889 (95% confidence interval 0.835-0.943,P<0.001) and 0.809 (95% confidence interval 0.709-0.909,P<0.001);the specificity were 0.842 and 0.526,respectively;the sensitivity were 0.815 and 0.954,respectively;and the Jordan index were 0.657 and 0.480,respectively.Conclusion　The patients with sPE have a higher risk of neonatal asphyxia,which may be related to the abnormal low expression of VEGF and IL-4 in serum.The serum VEGF and IL-4 levels have certain predictive value for the occurrence of neonatal asphyxia in patients with sPE.

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更新日期/Last Update: 2022-11-05