参考文献/References:
[1] WEIHRAUCH-BLHER S,SCHWARZ P,KLUSMANN J H.Childhood obesity:increased risk for cardiometabolic disease and cancer in adulthood[J].Metabolism,2019,92:147-152.
[2] 马冠生,张玉.中国儿童肥胖防控面临的挑战和机遇[J].中国儿童保健杂志,2020,28(2):117-119.
MA G S,ZHANG Y.Challenges and opportunities for prevention and control of childhood obesity in China[J].Chin J Child Health Care,2020,28(2):117-119
[3] RUIZO F J,ANGUITAR A,LEIS R,et al.Genetic factors and molecular mechanisms of vitamin D and obesity relationship[J].Ann Nutr Metab,2018,73(2):89-99.
[4] ZAKHAROVA I,KLIMOV L,KURYANINOVA V,et al.Vitamin D insufficiency in overweight and obese children and adolescents[J].Front Endocrinol (Lausanne),2019,10:103.
[5] DUR-TRAV T,GALLINAS-VICTORIANO F,CHUECA-GUINDULAIN M J,et al.Assessment of vitamin D status and parathyroid hormone during a combined intervention for the treatment of childhood obesity[J].Nutr Diabetes,2019,9(1):18.
[6] 许君,杨素红,叶蓓.肥胖儿童维生素D营养状况与胰岛素抵抗、内皮损伤及脂代谢的相关性分析[J].中国现代医生,2020,58(17):20-24.
XU J,YANG S H,YE B.Correlation analysis of vitamin D nutrition status with insulin resistance,endothelial damage and lipid metabolism in obese children[J].Chin Modern Doctors,2020,58(17):20-24.
[7] BACHA F,BARTZ S K,TOMSA A,et al.Free vitamin D:relationship to insulin sensitivity and vascular health in youth[J].J Pediatr,2019,212:28-34.
[8] ADIKARAM S G S,SAMARANAYAKE D B D L,ATAPATTU N,et al.Prevalence of vitamin D deficiency and its association with metabolic derangements among children with obesity[J].BMC Pediatr,2019,19(1):186.
[9] CORICA D,ZUSI C,OLIVIERI F,et al.Vitamin D affects insulin sensitivity and β-cell function in obese non-diabetic youths[J].Eur J Endocrinol,2019,181(4):439-450.
[10] PRAMONO A,JOCKEN J W E,BLAAK E E.Vitamin D deficiency in the aetiology of obesity-related insulin resistance[J].Diabetes Metab Res Rev,2019,35(5):e3146.
[11] HOSSAIN M J,LEVINSON A,GEORGE D,et al.Vitamin D status and cardiovascular risk in obesity:effect of physical activity in nonvitamin D supplemented adolescents[J].Metab Syndr Relat Disord,2018,16(4):197-203.
[12] BHOWMIK B,SIDDIQUE T,MAJUMDER A,et al.Maternal BMI and nutritional status in early pregnancy and its impact on neonatal outcomes at birth in Bangladesh[J].BMC Pregnancy Childbirth,2019,19(1):413.
[13] DARAKI V,ROUMELIOTAKI T,CHALKIADAKI G,et al.Low maternal vitamin D status in pregnancy increases the risk of childhood obesity[J].Pediatr Obes,2018,13(8):467-475.
[14] BOYLE V T,THORSTENSEN E B,THOMPSON J M D,et al.The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy:an observational study[J].Int J Obes(Lond),2017,41(12):1755-1760.
[15] 王剑清,刘艳明.维生素D调控儿童肥胖、胰岛素抵抗及其机制的研究进展[J].中华实用儿科临床杂志,2015,30(20):1598-1600.
WANG J Q,LIU Y M.Research progress of vitamin D regulating childhood obesity and insulin resistance and its mechanism[J].Chin J Appl Clin Pediatr,2015,30(20):1598-1600.
[16] CHANG E,KIM Y.Vitamin D insufficiency exacerbates adipose tissue macrophage infiltration and decreases AMPK/SIRT1 activity in obese rats[J].Nutrients,2017,9(4):338.
[17] 蔡小玲,哈小琴.正负调控胰岛素受体的分子蛋白研究进展[J].医学研究杂志,2019,48(5):179-181.
CAI X L,HA X Q.Research progress of molecular proteins that positively and negatively regulate insulin receptor[J].J Med Res,2019,48(5):179-181.
[18] 孙莹,梁晓春.维生素 D 缺乏在胰岛素抵抗中的作用及其中药研究价值[J].世界中西医结合杂志,2017,12(1):138-141.
SUN Y,LIANG X C.The role of vitamin D deficiency in insulin resistance and the research value of traditional Chinese medicine[J].World J Integr Tradit Chin Western Med,2017,12(1):138-141.
[19] PARK S,KIM D S,KANG S.Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-γ expression in nonobese type 2 diabetic rats[J].J Nutr Biochem,2016,27:257-265.
[20] KANG E J,LEE J E,AN S M,et al.The effects of vitamin D3 on lipogenesis in the liver and adipose tissue of pregnant rats[J].Int J Mol Med,2015,36(4):1151-1158.
[21] 吴文君,时俊锋,汤孙寅炎,等.固醇调节元件结合蛋白1c抑制骨骼肌胰岛素受体底物1基因表达的分子机制[J].中华糖尿病杂志,2015,7(12):754-758.
WU W J,SHI J F,TANG S Y Y,et al.Molecular mechanism of sterol regulatory element binding protein 1c inhibiting the expre-ssion of insulin receptor substrate gene in skeletal muscle[J].Chin J Diabetes Mellitus,2015,7(12):754-758.
[22] 向薇.1,25-(OH)2D3对脂肪细胞脂滴生长和细胞因子的作用研究[D].乌鲁木齐:新疆医科大学,2019.
XIANG W.Study on the effect of 1,25-(OH)2D3 on lipid droplet growth and cytokines in adipocytes[D].Urumqi:Xinjiang Medical University,2019.
[23] XU Y,LOU Y,KONG J.VDR regulates energy metabolism by modulating remodeling in adipose tissue[J].Eur J Pharmacol,2019,865:172761.
[24] ABBAS M A.Physiological functions of vitamin D in adipose tissue[J].Steroid Biochem Mol Biol,2017,165(Pt B):369-381.
[25] 刘贝贝,阳琰,李琪,等.1,25二羟基维生素D3对2型糖尿病大鼠肝脏中维生素D受体、脂联素受体2、过氧化物酶体增殖物激活受体α mRNA表达及甘油三酯含量的影响[J].中国糖尿病杂志,2018,26(1):55-58.
LIU B B,YANG Y,LI Q,et al.Effects of 1,25 dihydroxyvitamin D3 on the expression of vitamin D receptor,adiponectin receptor 2,peroxisome proliferator-activated receptor α mRNA and triglyceride content in the liver of type 2 diabetic rats[J].Chin J Diabetes,2018,26(1):55-58.
[26] W DRYCHOWICZ A,SZTEFKO K,STARZYK J B.Sclerostin and its association with insulin resistance in children and adolescents[J].Bone,2019,120:232-238.
[27] CRUJEIRAS A B,CARREIRA M C,CABIA B,et al.Leptin resistance in obesity:an epigenetic landscape[J].Life Sci,2015,140:57-63.
[28] KANEKO I,SABIR M S,DUSSIK C M,et al.1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes:implication for behavioral influences of vitamin D[J].FASEB J,2015,29(9):4023-4035.
[29] 郑若怡,张雨哲.肥胖相关性胰岛素抵抗发病机制的研究[J].实用糖尿病杂志,2019,15(4):71-73.
ZHENG R Y,ZHANG Y Z.Study on the pathogenesis of obesity-related insulin resistance[J].J Pract Diabetes,2019,15(4):71-73.
[30] KHAN R J,RIESTRA P,GEBREAB S Y,et al.Vitamin D receptor gene polymorphisms are associated with abdominal visceral adipose tissue volume and serum adipokine concentrations but not with body mass index or waist circumference in African Americans:the Jackson Heart Study[J].J Nutr,2016,146(8):1476-1482.
[31] 赖鹏斌,魏文锋,李彦,等.内脂素通过激活胰岛素受体底物1/胰岛素受体底物2信号调节胰岛βTc6细胞功能、胰十二指肠同源框因子1及过氧化物酶体增殖物激活受体γ表达的研究[J].中国糖尿病杂志,2020,28(6):453-460.
LAI P B,WEI W F,LI Y,et al.Study of visfatin regulating islet β Tc6 cell function,pancreatoduodenal homeobox factor 1 and peroxisome proliferator-activated receptor γ expression by activating insulin receptor substrate/insulin receptor substrate 2 signal[J].Chin J Diabetes,2020,28(6):453-460.
[32] EMAMI M R,SHARIFI A,YASERI M,et al.Vitamin D suppresses proangiogenic factors in patients with ulcerative colitis:a randomized double blind placebo controlled clinical trial[J].Complement Ther Clin Pract,2020,39:101086.
[33] RIVERA P,MARTOS-MORENO G ,BARRIOS V,et al.A novel approach to childhood obesity:circulating chemokines and growth factors as biomarkers of insulin resistance[J].Pediatr Obes,2019,14(3):e12473.
[34] LANDRIER J F,KARKENI E,MARCOTORCHINO J,et al.Vitamin D modulates adipose tissue biology:possible consequences for obesity[J].Proc Nutr Soc,2016,75(1):38-46.
[35] GARBOSSA S G,FOLLI F.Vitamin D,sub-inflammation and insulin resistance.A window on a potential role for the interaction between bone and glucose metabolism[J].Rev Endocr Metab Disord,2017,18(2):243-258.
[36] 黎明真,龙容.维生素D缺乏与肥胖儿童脂代谢、微炎症反应、内皮损伤的关系研究[J].海南医学院学报,2017,23(11):1548-1551.
LI M Z,LONG R.Relationship of vitamin D deficiency with lipid metabolism,micro-inflammatory resoponse and endothelial injury in obese children[J].J Hainan Med Univ,2017,23(11):1548-1551.
[37] LOTFI-DIZAJI L,MAHBOOB S,ALIASHRAFI S,et al.Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency:a double-blind placebo-controlled randomized clinical trial[J].Clin Endocrinol(Oxf),2019,90(1):94-101.
[38] SZYMCZAK I,PAWLICZAK R.The active metabolite of vitamin D3 as a potential immunomodulator[J].Scand Immunol,2016,83(2):83-91.
[39] FILGUEIRASM S,ROCHAN P,NOVAESJ F,et al.Vitamin D status,oxidative stress,and inflammation in children and adolescents:a systematic review[J].Crit Rev Food Sci Nutr,2020,60(4):660-669.
[40] 祝素萍,杜青,陈妙,等.肥胖儿童免疫状态与维生素D水平相关性研究[J].现代实用医学,2015,27(10):1335-1336.
ZHU S P,DU Q,CHEN M,et al.Study on the correlation between immune status and vitamin D level in obese children[J].Moden Pract Med,2015,27(10):1335-1336.
[41] 曹洁,朱亦堃,焦玉睿,等.2型糖尿病患者辅助性T细胞和调节性T细胞水平及其与胰岛素抵抗、胰岛B功能的相关性[J].广西医学,2019,41(12):1495-1498.
CAO J,ZHU Y K,JIAO Y R,et al.Helper T cell and regulatory T cell levels and their correlation with insulin resistance and islet β function in patients with type 2 diabetes mellitus[J].Guangxi Med J,2019,41(12):1495-1498.
[42] DIMITROV V,WHITE J H.Vitamin D signaling in intestinal innate immunity and homeostasis[J].Mol Cell Endocrinol,2017,453:68-78.
[43] MONTERO D,VICENTE-SALAR N,HERRANZ M,et al.Glutathione-dependent enzyme activities of peripheral blood mononuclear cells decrease during the winter season compared with the summer in normal-weight and severely obese adolescents[J].J Physiol Biochem,2019,75(3):321-327.
[44] FILGUEIRAS M S,ROCHA N P,NOVAES J F,et al.Vitamin D status,oxidative stress,and inflammation in children and adolescents:a systematic review[J].Crit Rev Food Sci Nutr,2020,60(4):660-669.
[45] FARHANGI M A,MESGARI-ABBASI M,HAJILUIAN G,et al.Adipose tissue inflammation and oxidative stress:the ameliorative effects of vitamin D[J].Inflammation,2017,40(5):1688-1697.
[46] MANSOURNIA M A,OSTADMOHAMMADI V,DOOSTI-IRANI A,et al.The effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients:asystematic review and meta-analysis of randomized controlled trials[J].Horm Metab Res,2018,50(6):429-440.
[47] BERRIDGE M J.Vitamin D cell signalling in health and disease[J].Biochem Biophys Res Commun,2015,460(1):53-71.
[48] SONG C,FU B,ZHANG J,et al.Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway[J].Sci Rep,2017,7(1):672.
[49] YU W,GAO B,LI N,et al.Sirt3 deficiency exacerbates diabetic cardiac dysfunction:role of Foxo3A-parkin-mediated mitophagy[J].Biochim Biophys Acta Mol Basis Dis,2017,1863(8):1973- 1983.
[50] DING X,JIAN T,WU Y,et al.Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway[J].Biomed Pharmacother,2019,110:85-94.
[51] ABBAS M A.Physiological functions of vitamin D in adipose tissue[J].J Steroid Biochem Mol.Biol,2017,165 (Pt B):369-381.
[52] LEPRETTI M,MARTUCCIELLO S,BURGOS ACEVES M A,et al.Omega-3 fatty acids and insulin resistance:focus on the regulation of mitochondria and endoplasmic reticulum stress[J].Nutrients,2018,10(3):350.
[53] BORGES C C,SALLES A F,BRINGHENTI I,et al.Vitamin D deficiency increases lipogenesis and reduces beta-oxidation in the liver of diet-induced obese mice[J].J Nutr Sci Vitaminol (Tokyo),2018,64(2):106-115.
[54] DI MEO S,IOSSA S,VENDITTI P.Skeletal muscle insulin resistance:role of mitochondria and other ROS sources[J].J Endocrinol,2017,233(1):R15-R42.
[55] 蒙青青,韦小妮,陈华干,等.肥胖儿童血清25羟维生素D及胰岛素抵抗研究[J].医学美学美容,2020,29(11):75.
MENG Q Q,WEI X N,CHEN H G,et al.Study on serum 25-hydroxyvitamin D and insulin resistance in obese children[J].Med Aesthet,2020,29(11):75.
[56] GRUNWALD T,FADIA S,BERNSTEIN B,et al.Vitamin D supplementation,the metabolic syndrome and oxidative stress in obese children[J].J Pediatr Endocrinol Metab,2017,30(4):383-388.
[57] BILICI M E,ERDEVE S,ETINKAYA S,et al.The effect of 2 000 IU/day vitamin D supplementation on insulin resistance and cardiovascular risk parameters in vitamin D deficient obese adolescents[J].Turk J Pediatr,2019,61(5):723-732.