[1]王进芳,王小菊,黄　飞,等.轮状病毒感染对轻度胃肠炎伴良性惊厥患儿临床特征及预后的影响[J].新乡医学院学报,2020,37(6):555-558.[doi:10.7683/xxyxyxb.2020.06.012]
　WANG Jinfang,WANG Xiaoju,HUANG Fei,et al.Effect of rotavirus infection on the clinical characteristics and prognosis of children with benign infantile convulsions associated with mild gastroenteritis[J].Journal of Xinxiang Medical University,2020,37(6):555-558.[doi:10.7683/xxyxyxb.2020.06.012]
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轮状病毒感染对轻度胃肠炎伴良性惊厥患儿临床特征及预后的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
37
期数:
2020年6
页码:
555-558
栏目:
临床研究
出版日期:
2020-06-05

文章信息/Info

Title:
Effect of rotavirus infection on the clinical characteristics and prognosis of children with benign infantile convulsions associated with mild gastroenteritis
作者:
王进芳1; 王小菊2; 黄　飞2; 陈丽娜2; 林　尧2
（1.锦州医科大学湖北医药学院附属随州市中心医院研究生培养基地，湖北　随州　441300；2.湖北医药学院附属随州市中心医院儿科，湖北　随州　441300）
Author(s):
WANG Jinfang1; WANG Xiaoju2; HUANG Fei2; CHEN Lina2; LIN Yao2
(1.Postgraduate Training Base of Suizhou Central Hospital Affiliated to Hubei University of Medicine,Jinzhou Medical University,Suizhou 441300,Hubei Province,China;2.Department of Pediatrics,Suizhou Central Hospital Affiliated to Hubei University of Medicine,Suizhou 441300,Hubei Province,China)
关键词:
轮状病毒; 胃肠炎; 惊厥
Keywords:
rotavirus; gastroenteritis; convulsion
分类号:
R725
DOI:
10.7683/xxyxyxb.2020.06.012
文献标志码:
A
摘要:
目的　探讨轮状病毒感染对轻度胃肠炎伴良性惊厥患儿（BICE）临床表现、实验室指标及预后的影响。方法　选择2017年4月至2018年4月随州市中心医院收治的98例BICE患儿为研究对象，根据粪便轮状病毒抗原检测结果分为轮状病毒阳性组（n=35）和轮状病毒阴性组（n=63）。收集2组患儿的一般资料、胃肠炎症状、惊厥特点、实验室检查指标、是否接种轮状病毒疫苗及1～2 a年随访结果（有无复发或转化为癫痫），并进行比较。结果　BICE好发于12～24月龄儿童，秋季为其发病高峰期。2组患儿的性别构成、起病年龄及发病月份比较差异均无统计学意义（P＞0.05）。2组患儿均在病程的第1～3天出现低热、呕吐、腹泻症状，且呕吐、腹泻症状轻微。2组患儿首次发热时间、首次呕吐时间、每日呕吐次数、首次腹泻时间、每日腹泻次数比较差异均无统计学意义（P＞0.05）。2组患儿首次惊厥发作均在病程的第1～3天，持续时间30 s至5 min，发作次数1～3次，表现形式均为全身阵挛型。2组患儿首次惊厥发作时间、惊厥发作次数比较差异无统计学意义（P＞0.05），轮状病毒阳性组患儿每次惊厥持续时间长于轮状病毒阴性组（P＜0.05）。接种轮状病毒疫苗患儿与未接种轮状病毒疫苗患儿的首次惊厥发作时间、惊厥发作次数比较差异无统计学意义（P＞0.05），接种轮状病毒疫苗患儿每次惊厥持续时间短于未接种轮状病毒疫苗患儿（P＜0.05）。2组患儿外周血WBC水平均无明显升高，血清Na+、K+、Ca2+、Cl-水平均在正常范围内。2组患儿外周血WBC水平及血清Na+、K+、Ca2+、Cl-水平比较差异均无统计学意义（P＞0.05），轮状病毒阳性组患儿血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶水平高于轮状病毒阴性组（P＜0.05）。2组患儿经积极治疗均治愈，出院后1～2 a内2组患儿均无复发或转化为癫痫者。结论　轮状病毒感染可使BICE患儿的肝功能受损，惊厥持续时间延长，但未加重胃肠炎症状，也不影响患儿预后，接种轮状病毒疫苗可能会减少BICE患儿的惊厥持续时间。
Abstract:
Objective　To investigate the effect of rotavirus infection on the clinical manifestations,laboratory indexes and prognosis of children with benign infantile convulsions associated with mild gastroenteritis (BICE).Methods　A total of 98 children with BICE admitted to Suizhou Central Hospital from April 2017 to April 2018 were selected as the study objects,and they were divided into positive rotavirus group (n=35) and negative rotavirus group (n=63) according to the results of rotavirus antigen detection in feces.The general data,gastroenteritis symptoms,convulsion characteristics,laboratory indexes,rotavirus vaccines vaccination and follow-up results within 1-2 years of children in the two groups were collected and compared.Results　Bice occured predominantly in children aged 12-24 months,and the peak incidence was in autumn.There was no significant difference in the gender composition,onset age and onset month between the two groups (P>0.05).The children in the two groups showed low fever,vomiting,diarrhea on the first to the third day of the course of disease,and the vomiting and diarrhea symptoms were mild.There was no significant difference in the time of first fever,the time of first vomiting,the times of daily vomiting,the time of first diarrhea and the times of daily diarrhea between the two groups (P>0.05).The first seizure of children in the two groups attacked on the first to third day of the course of disease,lasting for 30 seconds to 5 minutes,and the number of seizures was 1-3 times,and the manifestation was generalized clonic type.There was no significant difference in the first seizure time and the number of seizures between the two groups (P>0.05).The duration of convulsion in the positive rotavirus group was longer than that in the negative rotavirus group (P＜0.05).There was no significant difference in the first seizure time and the number of convulsions between the children with and without rotavirus vaccine (P>0.05).The duration of convulsion in the children with rotavirus vaccine was shorter than that in the children without rotavirus vaccine (P＜0.05).There was no significant increase in WBC level in peripheral blood of the children in the two groups.The levels of serum Na+　,K+　,Ca2+ and Cl-　 were within the normal range.There was no significant difference in WBC and serum Na+　,K+　,Ca2+ and Cl-　 levels between the two groups (P>0.05).The levels of serum alanine aminotransferase and aspartase amiontransferase in the positive rotavirus group were higher than those in the negative rotavirus group (P＜0.05).All the children in the two groups were cured by active treatment.There was no recurrence or conversion to epilepsy in the two groups within 1-2 years after discharge.Conclusion　Rotavirus infection can damage the liver function of children with BICE,prolong the duration of convulsion;but it does not aggravate the symptoms of gastroenteritis,and does not affect the prognosis of children.Rotavirus vaccination may reduce the duration of convulsion in children with BICE.

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更新日期/Last Update: 2020-06-05