[1]郑　航,张　峰,窦启锋.基于UPOINT系统盐酸坦索罗辛、地西泮单药或联合治疗Ⅲ型前列腺炎疗效比较[J].新乡医学院学报,2019,36(7):681-683.[doi:10.7683/xxyxyxb.2019.07.020]
　ZHENG Hang,ZHANG Feng,DOU Qi-feng.Comparison of the efficacy of tamsulosin hydrochloride,diazepam monotherapy or combination therapy for type Ⅲ prostatitis based on UPOINT system[J].Journal of Xinxiang Medical University,2019,36(7):681-683.[doi:10.7683/xxyxyxb.2019.07.020]
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基于UPOINT系统盐酸坦索罗辛、地西泮单药或联合治疗Ⅲ型前列腺炎疗效比较
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年7
页码:
681-683
栏目:
临床研究
出版日期:
2019-07-05

文章信息/Info

Title:
Comparison of the efficacy of tamsulosin hydrochloride,diazepam monotherapy or combination therapy for type Ⅲ prostatitis based on UPOINT system
作者:
郑　航; 张　峰; 窦启锋
（新乡医学院第三附属医院泌尿外科，河南　新乡　453003）
Author(s):
ZHENG Hang; ZHANG Feng; DOU Qi-feng
(Department of Urology，the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003，Henan Province,China)
关键词:
慢性前列腺炎; UPOINT系统; 地西泮; 盐酸坦索罗辛
Keywords:
type Ⅲ prostatitis; UPOINT; diazepam; tamsulosin hydrochloride
分类号:
R697+.33
DOI:
10.7683/xxyxyxb.2019.07.020
文献标志码:
A
摘要:
目的　比较盐酸坦索罗辛、地西泮单药或联合治疗UPOINT系统分型中Ⅲ型前列腺炎的疗效。方法　将新乡医学院第三附属医院2013年1月至2015年12月收治的1 103例UPOINT系统分型中Ⅲ型前列腺炎患者随机分为盐酸坦索罗辛组（n=366）、地西泮组（n=374）和联合用药组（n=363）。盐酸坦索罗辛组患者给予盐酸坦索罗辛缓释胶囊0.2 mg，口服，每晚1次；地西泮组患者给予地西泮片2.5 mg，口服，每日2次；联合用药组患者给予盐酸坦索罗辛缓释胶囊0.2 mg，口服，每晚1次；地西泮片2.5 mg，口服，每日2次。3组患者给药方法均为给药2周、停药2周、再服药2周；采用美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）评分评价3组患者的临床疗效，并观察3组患者的不良反应发生情况。结果　3组患者治疗前NIH-CPSI评分比较差异无统计学意义（P>0.05）；治疗2、4、6、8、12周后，3组患者NIH-CPSI评分均低于治疗前（P<0.05）,地西泮组和联合用药组患者NIH-CPSI评分均低于盐酸坦索罗辛组（P<0.05），地西泮组与联合用药组患者NIH-CPSI评分比较差异无统计学意义（P>0.05）。盐酸坦索罗辛组、地西泮组、联合用药组患者治疗总有效率分别为84.15%（308/366）、91.71%（343/374）、91.18%（331/363）；地西泮组和联合用药组患者治疗总有效率高于盐酸坦索罗辛组，差异有统计学意义（χ2=9.987、8.327，P<0.05）；地西泮组与联合用药组患者治疗总有效率比较差异无统计学意义（χ2=0.065，P>0.05）。结论　基于UPOINT系统地西泮治疗Ⅲ型前列腺炎患者的疗效优于盐酸坦索罗辛，与二者联合用药效果相当。
Abstract:
Objective　To compare the effect of tamsulosin hydrochloride,diazepam monotherapy or combination therapy for type Ⅲ prostatitis based on UPOINT system.Methods　A total of 1 103 patients with type Ⅲ prostatitis based on UPOINT system admitted to the Third Affiliated Hospital of Xinxiang Medical University from January 2013 to December 2015 were randomly divided into tamsulosin hydrochloride group (n=366),diazepam group (n=374) and combined medication group (n=363).The patients in the tamsulosin hydrochloride group received 0.2 mg of tamsulosin hydrochloride sustained-release capsules once a day,orally;the patients in the diazepam group were given diazepam 2.5 mg orally,twice a day;and the patients in the combination group were given tamsulosin hydrochloride sustained-release capsule (0.2 mg,oral,once a night) and diazepam (2.5 mg,oral,twice a day).The drug administration methods of the three groups were two weeks of drug administration,two weeks of drug withdrawal,and two weeks of drug administration.The clinical effect of patients in the three groups was evaluated by the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI).The adverse reactions were observed in the three groups.Results　Before treatment,there was no statistically significant difference in the NIH-CPSI scores among the three groups (P>0.05).After 2,4,6,8,and 12 weeks of treatment,the NIH-CPSI scores of patients in the three groups were lower than those before treatment (P<0.05);the NIH-CPSI scores of patients in the diazepam group and the combination group were lower than those in the tamsulosin hydrochloride group (P<0.05);but there was no statistically significant difference in the NIH-CPSI scores of patients between the diazepam group and the combined medication group (P>0.05).The total effective rate in the tamsulosin hydrochloride group,diazepam group and combined medication group was 86.89% (308/366),91.71% (343/374) and 91.18% (331/363),respectively.The total effective rate in the diazepam group and the combined medication group was higher than that in the tamsulosin hydrochloride group(χ2=9.987,8.327;P<0.05).There was no statistically significant difference in the total effective rate between the diazepam group and the combined medication group (χ2=0.065，P>0.05).Conclusion　The effect of diazepam in the treatment of patients with type Ⅲ prostatitis base on UPOINT system is better than that of tamsulosin hydrochloride,and the effect of diazepam is similar to that of the combination of diazepam and tamsulosin hydrochloride.

参考文献/References:

［1］　郭应禄，李宏军.前列腺炎［M］.人民军医出版社，2007:68.
［2］　LITWIN M S，MCNAUGHTON-COLLINS M，FOWLER F J J R，et al.The National prostatitis symptom index:development institutes of health chronic and validation of a new outcome measure［J］.J Urol，1999，162(2):369-375.
［3］　SHOSKES D A，NICHEL J C，RACKLEY R R，et al.Clinical phenotyping in chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis：a management atrategy for urological chronic pelvic pain syndromes［J］.Prostate Cancer Prostatic Dis,2009,12(2):177-183.
［4］　SHOSKES D A，NICHEL J C，KATTAN M W.Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome:a prospective study using UPOINT［J］.Urology,2010,75(6):1249-1253.
［5］　戴维灿.介绍美国国立卫生研究院慢性前列腺炎症状积分指数（NIH-CPSI）［J］.中国男科学杂志，2000，14（1）：62.
［6］　王平，王侠，刘屹立，等.慢性前列腺炎诊治和疗效评价：附600例报告［J］.中华泌尿外科杂志，2001，9（22）：528-530.
［7］　COLLINS M M,STAFFORD R S,O′LEARY M P,et al.How common is prostatitis? A national survey of physician visits［J］.J Urol,1998,159:1224-1228.
［8］　ROBERTS R O,LIEBER M M,BOSTWICK D G,et al.A review of clinical and pathological prostatitis syndrome［J］.Urology,1997,49:809-821.
［9］　宋旭，漆贯华，汤鹏，等.慢性骨盆疼痛综合征的综合性治疗［J］.中华男科学，2004，6(10):429-433.
［10］　ZERMANN D H，ISHIGOOKA M，DOGGWEILER W R,et al.The male chronic pelvic pain syndrome［J］.World J Urol，2001,19(3):173-179.

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更新日期/Last Update: 2019-07-05