[1]李 琦.丁苯酞软胶囊联合清脑益智方治疗血管性痴呆疗效观察[J].新乡医学院学报,2019,36(7):677-680.[doi:10.7683/xxyxyxb.2019.07.019]
 LI Qi.Effect of butylphthalide soft capsule combined with Qingnao Yizhi Decoction in the treatment of vascular dementia[J].Journal of Xinxiang Medical University,2019,36(7):677-680.[doi:10.7683/xxyxyxb.2019.07.019]
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丁苯酞软胶囊联合清脑益智方治疗血管性痴呆疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年7
页码:
677-680
栏目:
临床研究
出版日期:
2019-07-05

文章信息/Info

Title:
Effect of butylphthalide soft capsule combined with Qingnao Yizhi Decoction in the treatment of vascular dementia
作者:
李 琦
(西安市中医医院脑病科,陕西 西安 710021)
Author(s):
LI Qi
(Department of Encephalopathy,Xi′an Hospital of Traditional Chinese Medicine,Xi′an 710021,Shaanxi Province,China)
关键词:
血管性痴呆清脑益智方丁苯酞软胶囊认知功能血管内皮生长因子脑源性神经营养因子
Keywords:
vascular dementiaQingnao Yizhi Decoctionbutylphthalide soft capsulecognitive functionvascular endothelial growth factorbrain-derived neurotrophic factor
分类号:
R743
DOI:
10.7683/xxyxyxb.2019.07.019
文献标志码:
A
摘要:
目的 探讨丁苯酞软胶囊联合清脑益智方治疗血管性痴呆(VD)的临床效果。方法 选择2014年4月至2017年5月西安市中医医院收治的86例VD患者为研究对象,根据治疗方法将患者分为观察组和对照组,每组43例;2组患者均给予营养脑神经、调节血脂及改善脑循环等常规治疗,在常规治疗基础上,对照组患者给予丁苯酞软胶囊治疗,观察组患者给予丁苯酞软胶囊和清脑益智方联合治疗。2组患者分别于治疗前后检测血清丙二醛(MDA)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、脑源性神经营养因子(BDNF)及血管内皮生长因子(VEGF)水平,应用简易精神状况检查(MMSE)评分评估患者认知功能;治疗后,根据患者总体衰退量表(GDS)分级评估临床疗效。结果 治疗前2组患者血清MDA、CAT、GSH-Px、SOD、BDNF及VEGF水平比较差异无统计学意义(P>0.05);与治疗前比较,治疗后2组患者血清MDA水平显著降低,CAT、GSH-Px、SOD、BDNF及VEGF水平显著升高(P<0.05);治疗后,观察组患者血清MDA水平显著低于对照组,CAT、GSH-Px、SOD、BDNF及VEGF水平显著高于对照组(P<0.05)。治疗前2组患者MMSE评分比较差异无统计学意义(P>0.05),2组患者治疗后MMSE评分显著高于治疗前(P<0.05);治疗后,观察组患者MMSE评分显著高于对照组(P<0.05)。观察组和对照组患者治疗总有效率分别为90.70%(39/43)、69.77%(30/43),观察组患者总有效率高于对照组(χ2=5.939,P<0.05)。结论 丁苯酞软胶囊联合清脑益智方可以促进VD患者新生血管形成,保护神经细胞,改善氧化应激状态和患者认知功能。
Abstract:
Objective To investigate the clinical effect of butylphthalide soft capsule combined with Qingnao Yizhi Decoction in the treatment of vascular dementia (VD).Methods Eighty-six patients with VD admitted to Xi′an Hospital of Traditional Chinese Medicine from April 2014 to May 2017 were selected as the subjects.The patients were divided into observation group and control group according to the treatment method,43 cases in each group.The patients in the two groups were given routine treatment such as nourishing brain nerve,regulating blood lipid and improving cerebral circulation.On the basis of routine treatment,the patients in the control group were treated with butylphthalide soft capsule,while the patients in the observation group were treated with butylphthalide soft capsule and Qingnao Yizhi Decoction.The levels of serum malondialdehyde (MDA),catalase (CAT),glutathione peroxidase (GSH-Px),superoxide dismutase (SOD),brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were detected;and the cognitive function was assessed by mini-mental state examination (MMSE) before and after treatment.The clinical effect was evaluated by global deterioration scale (GDS) after treatment.Results There was no significant difference in the levels of serum MDA,CAT,GSH-Px,SOD,BDNF and VEGF between the two groups before treatment (P>0.05).Compared with before treatment,the level of serum MDA decreased significantly after treatment,while the levels of CAT,GSH-Px,SOD,BDNF and VEGF increased significantly after treatment in the two groups (P<0.05).After treatment,the serum MDA level in the observation group was significantly lower than that in the control group,and the levels of serum CAT,GSH-Px,SOD,BDNF and VEGF in the observation group were significantly higher than those in the control group (P<0.05).There was no significant difference in MMSE score between the two groups before treatment (P>0.05).The MMSE score after treatment was significantly higher than that before treatment in the two groups (P<0.05).The MMSE score in the observation group was significantly higher than that in the control group after treatment (P<0.05).The total effective rate in the observation group and the control group was 90.70% (39/43) and 69.77% (30/43),respectively.The total effective rate in the observation group was higher than that in the control group (χ2=5.939,P<0.05).Conclusion Butylphthalide soft capsule combined with Qingnao Yizhi Decoction can promote neovascularization,protect nerve cells,improve oxidative stress and cognitive function of VD patients.

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更新日期/Last Update: 2019-07-05