[1]杨振方.纳米碳染色对早期结肠癌内镜黏膜下剥离术后追加手术效果的影响[J].新乡医学院学报,2018,35(11):994-996.[doi:10.7683/xxyxyxb.2018.11.012]
　YANG Zhen-fang.Effect of nano-carbon staining on additional operation after endoscopic submucosal dissection for early colon cancer[J].Journal of Xinxiang Medical University,2018,35(11):994-996.[doi:10.7683/xxyxyxb.2018.11.012]
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纳米碳染色对早期结肠癌内镜黏膜下剥离术后追加手术效果的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年11
页码:
994-996
栏目:
临床研究
出版日期:
2018-11-05

文章信息/Info

Title:
Effect of nano-carbon staining on additional operation after endoscopic submucosal dissection for early colon cancer
作者:
杨振方
（驻马店市中心医院胃肠外科，河南　驻马店　463000）
Author(s):
YANG Zhen-fang
(Department of Gastrointestinal Surgery,Zhumadian Central Hospital,Zhumadian 463000,Henan Province,China)
关键词:
结肠癌; 追加手术; 纳米碳; 病灶定位
Keywords:
colon cancer; additional operation; nano-carbon; lesion location
分类号:
R735.3+5
DOI:
10.7683/xxyxyxb.2018.11.012
文献标志码:
A
摘要:
目的　探讨纳米碳染色对早期结肠癌内镜黏膜下剥离术（ESD）后追加手术效果的影响。方法　选择2015年1月至2018年1月于驻马店市中心医院行ESD及追加手术的早期结肠癌患者92例，其中46例患者于ESD结束前应用纳米碳染色定位病灶（观察组），46例患者于ESD结束前未使用纳米碳染色定位病灶（对照组）。对2组患者病灶定位时间、病灶与上切缘距离、手术时间、淋巴结清扫数目、术中出血量及术后首次排气时间、首次下床活动时间、首次进食流质食物时间、住院时间、并发症发生率进行比较。结果　观察组患者病灶定位时间、手术时间显著短于对照组，病灶与上切缘距离显著短于对照组，淋巴结清扫数目、术中出血量显著少于对照组（P<0.05）。2组患者术后首次排气时间、首次下床活动时间、首次进食流质食物时间及住院时间比较差异均无统计学意义（P>0.05）。观察组和对照组患者并发症发生率分别为8.70%（4/46）、19.57%（9/46），观察组患者并发症发生率低于对照组（χ2=7.435，P<0.05）。结论　早期结肠癌ESD后追加手术行纳米碳染色标记能够快速定位病灶，缩短病灶与上切缘距离，减少手术时间和术中出血量，降低并发症发生率。
Abstract:
Objective　To investigate the effect of nano-carbon staining on the additional operation after endoscopic submucosal dissection (ESD) for early colon cancer.Methods　A total of 92 patients with early colon cancer who underwent ESD and additional surgery in Zhumadian Central Hospital were selected from January 2015 to January 2018.Among them,46 patients were performed with nano-carbon staining before the end of ESD (observation group),and 46 patients were not treated with nano-carbon staining before the end of ESD (control group).The lesion location time,distance between lesion and upper incisal margin,operation time,the number of lymph node dissection,intraoperative bleeding volume,the first exhaust time,first ambulation time,first eating liquid food time,hospitalization time and the incidence of complications were compared between the two groups.Results　Compared with the control group,the lesion location time,operation time and the distance between the lesion and the upper incisal margin shortened significantly;the number of lymph node dissection and intraoperative bleeding volume reduced significantly in the observation group (P<0.05).There was no significant difference in the first exhaust time,first ambulation time,first eating liquid food time and hospitalization time after operation between the two groups (P>0.05).The incidence of complications in the observation group and control group was 8.70% (4/46) and 19.57% (9/46),respectively.The incidence of complications in the observation group was lower than that in the control group (χ2=7.435,P<0.05).Conclusion　Nano-carbon staining on the additional operation after ESD for early colon cancer can quickly locate the lesion,shorten the distance between the lesion and the upper incisal margin,reduce the operation time and intraoperative bleeding volume,and reduce the incidence of complications.

参考文献/References:

［1］　于秀芝，朱清海，刘海龙，等.单纯腹腔镜与腹腔镜联合肛门内镜手术在左半结肠癌根治术中的应用效果比较［J］.新乡医学院学报，2017，34（3）：224-227.
［2］　TIAN X Y,WEI Z B,WANG J,et al.MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling［J］.Oncol Rep,2015,34(2):707-714.
［3］　PUGLISI M A,CENCIARELLI C,TESORI V,et al.High nitric oxide production,secondary to inducible nitric oxide synthase expression,is essential for regulation of the tumour-initiating properties of colon cancer stem cells［J］.J Pathol,2015,236(4):479-490.
［4］　陈鸿，周晓俊，杨龙，等.纳米碳淋巴示踪剂在腹腔镜早期胃癌根治术中的应用［J］.江苏医药，2017，43（1）：23-25.
［5］　黄军，郑海伦，王启之，等.微探头超声内镜辅助内镜治疗消化道黏膜下肿物291例临床分析［J］.中华全科医学，2017，15（12）：2038-2041.
［6］　麦麦提·艾合麦提，刘少壮，陈成，等.术前胃镜下纳米碳标记在腹腔镜胃癌根治术中的应用价值［J］.腹腔镜外科杂志，2018，23（1）：31-35.
［7］　张慧文，白俊文.乳腺癌前哨淋巴结检出方法研究进展［J］.肿瘤研究与临床，2017，29（1）：66-70.
［8］　方敏，吴凯男，林健，等.术前超声引导下亚甲蓝注射定位法切除触诊阴性乳腺肿块1例［J］.中华乳腺病杂志：电子版，2017，11（1）：55-56.DOI：10.3877/cma.j.issn.1674-0807.2017.01.012.
［9］　白预弘.功能化多壁碳纳米管对小鼠生殖毒性的研究［D］.济南：山东大学，2011.
［10］　卢艳，姚德生，韦金颖，等.纳米炭在腹腔镜下早期宫颈癌前哨淋巴结示踪的临床研究［J］.现代妇产科进展，2017，26（2）：109-112，115.
［11］　林晓萌，陈鹊汀，韩倩倩，等.纳米活性炭联合吲哚菁绿定位前哨淋巴结的效果［J］.中国老年学杂志，2017，37（20）：4990-4992.
［12］　谢毅，姜燕，刘宗旸，等.纳米碳甲状旁腺淋巴负显影技术在慢性肾脏病SHPT患者手术中的应用［J］.重庆医学，2017，46（18）：2489-2491.

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更新日期/Last Update: 2018-11-05