[1]严明珠,张　婷,赵艳秋,等.延续性护理对广泛期小细胞肺癌患者化学治疗依从性及生存状况的影响[J].新乡医学院学报,2018,35(5):435-438.[doi:10.7683/xxyxyxb.2018.05.021]
　YAN Ming-zhu,ZHANG Ting,ZHAO Yan-qiu,et al.Effects of continuous nursing on the chemotherapy compliance and survival status of patients with extensive-stage small cell lung cancer[J].Journal of Xinxiang Medical University,2018,35(5):435-438.[doi:10.7683/xxyxyxb.2018.05.021]
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延续性护理对广泛期小细胞肺癌患者化学治疗依从性及生存状况的影响
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年5
页码:
435-438
栏目:
护理研究
出版日期:
2018-05-05

文章信息/Info

Title:
Effects of continuous nursing on the chemotherapy compliance and survival status of patients with extensive-stage small cell lung cancer
作者:
严明珠; 张　婷; 赵艳秋; 吴红波
（郑州大学附属肿瘤医院内科学部，河南　郑州　450001）
Author(s):
YAN Ming-zhu; ZHANG Ting; ZHAO Yan-qiu; WU Hong-bo
（Department of Internal Medicine，the Affiliated Tumor Hospital of Zhengzhou University，Zhengzhou 450001，Henan Province，China）
关键词:
延续性护理; 广泛期小细胞肺癌; 化学治疗; 依从性; 生活质量
Keywords:
continuous nursing; extensive-stage small cell lung cancer; chemotherapy; compliance; quality of life
分类号:
R734.2
DOI:
10.7683/xxyxyxb.2018.05.021
文献标志码:
A
摘要:
目的　探讨延续性护理对广泛期小细胞肺癌（SCLC）患者化学治疗依从性、生存质量及生存时间的影响。方法　选择2013年3月至2015年3月郑州大学附属肿瘤医院收治的广泛期SCLC患者80例，根据护理措施分为观察组和对照组，每组40例。2组患者均给予常规出院指导，观察组患者在常规出院指导的基础上给予出院后延续性护理干预2 a，对2组患者化学治疗依从性、不良反应、心理状态、生活质量及总生存期进行比较。结果　观察组和对照组患者完成化学治疗周期数分别为5.30±0.14、4.85±0.18，观察组患者化学治疗周期数多于对照组（t=0.043，P<0.05）。观察组患者完成6个化学治疗周期者24例（60.0%），对照组患者完成6个化学治疗周期者15例（37.5%），观察组患者6个化学治疗周期完成率高于对照组（χ2=4.051，P<0.05）。观察组和对照组患者化学治疗前心理状态评分分别为35.30±4.12、36.29±2.21，化学治疗结束后4周心理状态评分分别为19.17±3.18、25.00±2.78，化学治疗前2组患者心理状态评分比较差异无统计学意义（t=0.245，P>0.05），2组患者化学治疗结束后4周心理状态评分显著低于化学治疗前（t=10.105、13.297，P<0.05），化学治疗结束后4周观察组患者心理状态评分显著低于对照组（t=12.614，P<0.05）。化学治疗后4周，观察组患者生理状况、社会/家庭状况、情感状况及功能状况显著优于对照组（P<0.05）。观察组和对照组患者中位生存时间分别为13.25、12.50个月，2组患者中位生存时间比较差异无统计学意义（P>0.05，RR=1.108，95%可信区间为0.687～1.788）。结论　延续性护理可以提高广泛期SCLC患者的化学治疗依从性，减轻不良反应，改善患者心理状态和生存质量。
Abstract:
Objective　To investigate the effect of continuous nursing on the chemotherapy compliance，quality of life and survival time of the patients with extensive-stage small cell lung cancer （SCLC）.Methods　A total of 80 patients with extensive-stage SCLC were selected from March 2013 to March 2015 in the Affiliated Tumor Hospital of Zhengzhou University.The patients were divided into the observation group and the control group according to the nursing measures，with 40 cases in each group.The patients in the two groups were given routine discharging guidance，and the patients in the observation group were given continuous nursing intervention on the basis of routine discharging guidance.The chemotherapy compliance，adverse reaction，mental state，quality of life and total survival time were compared between the two groups.Results　The number of completing chemotherapeutic cycle of patients in the observation group and the control group was 5.30±0.14 and 4.85±0.18 respectively，the number of completing chemotherapeutic cycle in the observation group was significantly more than that in the control group（t=0.043，P<0.05）.A total of 24 （60.0%） patients had completed 6 chemotherapy cycles in the observation group，and 15 （37.5%） patients had completed 6 chemotherapy cycles in the control group；the completion rate of 6 chemotherapy cycles in the observation group was significantly higher than that in the control group （χ2=4.051，P<0.05）.The mental state scores of the patients in the observation group and the control group were 35.30±4.12 and 36.29±2.21 before chemotherapy respectively，and they were 19.17±3.18 and 25.00±2.78 at four weeks after chemotherapy.There was no significant difference in mental state score between the two groups before chemotherapy （t=0.245，P>0.05），the mental state score at four weeks after chemotherapy was significantly lower than that before chemotherapy in the two groups （t=10.105，13.297，P<0.05），the mental state score in the observation group was significantly lower than that in the control group at four weeks after chemotherapy （t=12.614，P<0.05）.The physiological status，society and family status，emotional status and functional status of the patients in the observation group were significantly better than those in the control group at four weeks after chemotherapy （P<0.05）.The median survival time of the patients in the observation group and the control group was 13.25 and 12.50 months respectively，there was no significant difference in the median survival time between the two groups （P>0.05，RR=1.108，95% CI：0.687-1.788）.Conclusion　Continuous nursing can improve the chemotherapy compliance，reduce the adverse reaction and improve the mental state and quality of life of the patients with extensive-stage SCLC.

参考文献/References:

［1］　BYERS L A，RUDIN C M.Small cell lung cancer：where do we go from here［J］.Cancer，2015，121（5）：664-672.
［2］　ASAI N，OHKUNI Y，KANEKO N，et al.Relapsed small cell lung cancer：treatment options and latest developments［J］.Ther Adv Med Oncol，2014，6（2）：69-82.
［3］　吴碧珊，李津.综合护理干预对乳腺癌患者术后生存质量、不良情绪的影响［J］.中国医药科学，2017，7（11）：110-112.
［4］　张红娟，袁桃花，贾蕊，等.化学治疗肿瘤患者实施延续护理干预效果分析［J］.新乡医学院学报，2017，34（2）：160-162.
［5］　KALEMKERIAN G P，AKERLEY W，BOGNER P，et al.Small cell lung cancer：clinical practice guidelines in oncology［J］.J Nat Compr Canc Netw，2013，11（1）：78-98.
［6］　石远凯，孙燕，于金明，等.中国晚期原发性肺癌诊治专家共识：2016年版［J］.中国肺癌杂志，2016，19（1）：1-15.
［7］　赵跃，刘伟，黄景昊，等.浅谈癌症诊疗中科学精神与人文精神的融合［J］.医学与哲学，2018，39（1B）：76-79.
［8］　杨海霞.延续护理模式对宫颈癌患者生活质量和抑郁焦虑的影响［J］.中国健康心理学杂志，2017，25（8）：1155-1158.
［9］　BUNN P A，MINNA J，AUGUSTYN A，et al.Small cell lung cancer：can recent advances in biology and molecular biology be translated into improved outcomes［J］.J Thorac Oncol，2016，11（4）：453-474.
［10］　VAN DER SPEK N，VOS J，VAN UDEN-KRAAN C F，et al.Efficacy of meaning-centered group psychotherapy for cancer survivors：a randomized controlled trial［J］.Psychol Med，2017，47（11）：1990-2001.

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更新日期/Last Update: 2018-05-05