[1]肖　莉.血清葡萄糖-6-磷酸异构酶测定在类风湿关节炎活动性判断中的应用价值[J].新乡医学院学报,2018,35(5):432-434.[doi:10.7683/xxyxyxb.2018.05.020]
　XIAO Li.Value of serum glucose-6-phosphoric isomerase in the activity judgment of rheumatoid arthritis[J].Journal of Xinxiang Medical University,2018,35(5):432-434.[doi:10.7683/xxyxyxb.2018.05.020]
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血清葡萄糖-6-磷酸异构酶测定在类风湿关节炎活动性判断中的应用价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年5
页码:
432-434
栏目:
临床研究
出版日期:
2018-05-05

文章信息/Info

Title:
Value of serum glucose-6-phosphoric isomerase in the activity judgment of rheumatoid arthritis
作者:
肖　莉
(新乡市中心医院检验科,河南　新乡　453000)
Author(s):
XIAO Li
（Department of Clinical Laboratory,Xinxiang Central Hospital, Xinxiang 453000,Henan Province,China）
关键词:
类风湿关节炎; 活动性; 诊断; 葡萄糖-6-磷酸异构酶
Keywords:
rheumatoid arthritis;  activity;  diagnosis;  glucose-6-phosphate isomerase
分类号:
R593.22
DOI:
10.7683/xxyxyxb.2018.05.020
文献标志码:
A
摘要:
目的　分析血清葡萄糖-6-磷酸异构酶（GPI）在类风湿关节炎（RA）活动性评估中的应用价值。方法　选择2015年1月至2017年1月新乡市中心医院收治的80例RA患者（RA组），选择同期收治的系统性红斑狼疮（SLE）20例、强直性脊柱炎（AS）10例作为风湿病对照组，另选择同期体检健康者30例作为正常对照组。抽取所有研究对象外周静脉血，采用酶联免疫吸附试验测定血清GPI水平，分析GPI与RA活动性的关系。结果　RA组患者血清GPI水平高于风湿病对照组与正常对照组，风湿病对照组患者血清GPI高于正常对照组（P<0.05）。RA组活动期患者血清GPI水平高于RA组非活动期患者、正常对照组与风湿病对照组（包括SLE和AS患者）（P<0.05）;RA组非活动期患者血清GPI高于正常对照组和风湿病对照组（包括SLE和AS患者）（P<0.05）。GPI诊断RA的受试者工作特征曲线（ROC）下面积为0.735，最佳临界值为0.73 mg·L-1，当GPI为0.73 mg·L-1时，GPI诊断RA的敏感度为79.0%，特异度为64.5%。GPI与RA疾病活动性呈正相关（r=0.723，P<0.05）。结论　RA患者血清GPI水平高于正常人及其他风湿免疫性疾病患者，且其水平的变化与疾病活动度呈正相关。
Abstract:
Objective　To analyze the value of serum glucose-6-phosphate isomerase (GPI) in evaluating the activity of rheumatoid arthritis (RA).Methods　Eighty patients with RA in the Xinxiang Central Hospital from January 2015 to January 2017 were selected(RA group); twenty patients with systemic lupus erythematosus (SLE) and 10 patients with ankylosing spondylitis (AS) were selected as the rheumatism control group, and 30 cases of healthy people were selected as the normal control group.Peripheral venous blood of all subjects was collected to determine the serum GPI level by enzyme linked immunosorbent assay.The relationship between GPI and the activity of RA was analyzed.Results　The serum GPI level in RA group was significantly higher than that in the rheumatism control group and normal control group (P<0.05);the serum GPI level in rheumatism control group was significantly higher than that in the normal control group (P<0.05).The serum GPI level in active stage patients of RA group was significantly higher than that in the non-active stage patients of RA group，normal control group and rheumatism control group(including SLE and AS patients) (P<0.05);the serum GPI level in non-active stage patients of RA group was significantly higher than that in the normal control group and the rheumatism control group(including SLE and AS patients) (P<0.05).The area under the receiver operating characteristic curve（ROC）of GPI for diagnosing of RA was 0.735 and the best critical value of GPI for diagnosis of RA was 0.73 mg·L-1.When the GPI was 0.73 mg·L-1, the diagnostic sensitivity and specificity of GPI were 79.0% and 64.5% respectively.GPI was positively correlated with the activity of RA.Conclusion　The serum GPI level of RA patients is higher than healthy people and the other rheumatic autoimmune disease, and the level of GPI is positively correlated with the activity of the RA

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更新日期/Last Update: 2018-05-05