[1]任　波.胃癌患者化学治疗前后血清血红蛋白、血管内皮生长因子、癌胚抗原、糖链抗原19-9和糖链抗原125水平变化及临床意义[J].新乡医学院学报,2017,34(11):998-1001.[doi:10.7683/xxyxyxb.2017.11.011]
　REN Bo.Clinic significant change of serum hemoglobin，vascular endothelial growth factor，carcinoembryonic antigen，carbohydrate antigen 19-9 & carbohydrate antigen 125 in gastric cancer patients chemotherapy[J].Journal of Xinxiang Medical University,2017,34(11):998-1001.[doi:10.7683/xxyxyxb.2017.11.011]
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胃癌患者化学治疗前后血清血红蛋白、血管内皮生长因子、癌胚抗原、糖链抗原19-9和糖链抗原125水平变化及临床意义
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年11
页码:
998-1001
栏目:
临床研究
出版日期:
2017-11-05

文章信息/Info

Title:
Clinic significant change of serum hemoglobin，vascular endothelial growth factor，carcinoembryonic antigen，carbohydrate antigen 19-9 & carbohydrate antigen 125 in gastric cancer patients chemotherapy
作者:
任　波
（铜川矿务局中心医院消化内科，陕西　铜川　727000）
Author(s):
REN Bo
（Department of Gastroenterology，the Central Hospital of Tongchuan Mining Bureau，Tongchuan 727000，Shaanxi Province，China）
关键词:
胃癌; 化学治疗; 血红蛋白; 血管内皮生长因子; 癌胚抗原; 糖链抗原19-9; 糖链抗原125
Keywords:
gastric cancer; chemotherapy; hemoglobin; vascular endothelial growth factor; carcinoembryonic antigen; carbohydrate antigen 19-9; carbohydrate antigen 125
分类号:
R735.2
DOI:
10.7683/xxyxyxb.2017.11.011
文献标志码:
A
摘要:
目的　探讨胃癌患者化学治疗前后血清血红蛋白（HGB）、血管内皮生长因子（VEGF）、癌胚抗原（CEA）、糖链抗原19-9（CA19-9）和糖链抗原125（CA125）水平变化与化学治疗效果的相关性。方法　选取铜川矿务局中心医院2015年6月至2016年6月收治的胃癌患者100例，均采用以氟尿嘧啶类和紫杉醇类药物为基础的化学治疗方案，分别于化学治疗前及化学治疗1个周期后检测血清HGB、VEGF、CEA、CA19-9和CA125水平；并于化学治疗2个周期后进行疗效评价。结果　100例患者治疗2个周期后部分缓解25例（有效组），疾病稳定37例（疾病稳定组），疾病进展38例（疾病进展组）。100例患者化学治疗前后血清HGB水平比较差异无统计学意义（P>0.05），但化学治疗后血清VEGF、CEA、CA19-9和CA125 水平显著低于化学治疗前（P<0.05）。化学治疗前3组患者血清HGB、VEGF、CEA、CA19-9及CA125水平比较差异均无统计学意义（P>0.05）。有效组患者化学治疗后血清HGB、VEGF、CEA、CA19-9及CA125水平显著低于化学治疗前（P<0.05）；疾病稳定组患者化学治疗前后血清HGB、VEGF、CEA、CA19-9及CA125水平比较差异均无统计学意义（P>0.05）；疾病进展组患者化学治疗前后血清HGB、VEGF、CEA及CA19-9水平比较差异无统计学意义（P>0.05），但化学治疗后血清CA125水平显著高于化学治疗前（P<0.05）。化学治疗后，有效组患者血清HGB、VEGF、CEA、CA19-9及CA125水平显著低于疾病稳定组和疾病进展组（P<0.05）；疾病稳定组与疾病进展组患者血清HGB、VEGF及CA19-9水平比较差异无统计学意义（P>0.05），但疾病稳定组患者血清CEA和CA125水平显著低于疾病进展组（P<0.05）。多重回归分析结果显示，血清CEA、CA19-9、CA125和VEGF水平变化与化学治疗效果显著相关（P<0.05），相关性从大至小依次为CEA、CA19-9、CA125和VEGF；血清HGB水平变化与化学治疗效果无相关性（P>0.05）。结论　血清CEA、CA19-9、CA125和VEGF水平变化与胃癌患者化学治疗效果有相关性，检测血清CEA、CA19-9、CA125和VEGF水平有助于预测化学治疗效果。
Abstract:
Objective　To observe the changes of the levels of serum hemoglobin （HGB），vascular endothelial growth factor （VEGF），carcinoembryonic antigen （CEA），carbohydrate antigen 19-9 （CA19-9） and carbohydrate antigen 125 （CA125） in patients with gastric cancer before and after chemotherapy；and to investigate the correlation between the changes of the levels of the serum indexes and the effect of chemotherapy.Methods　A total of 100 patients with gastric cancer were selected from June 2015 to June 2016 in the Central Hospital of Tongchuan Mining Bureau.All patients were treated with the primary chemotherapy regimen with fluorouracil and paclitaxel.The levels of serum HGB，VEGF，CEA，CA19-9 and CA125 were detected before and after one cycle of chemotherapy.The curative effect was evaluated after two cycles of chemotherapy.Results　Among the 100 patients after two cycles of chemotherapy，there were 25 cases with partial remission（effective group），37 cases with stable disease（stable disease group） and 38 cases with progressive disease （progressive disease group）.There was no significant differences in serum HGB level of the 100 patients before and after chemotherapy （P>0.05），but the levels of serum VEGF，CEA，CA19-9 and CA125 after chemotherapy were significantly lower than those before chemotherapy （P<0.05）.There was no significant difference in serum HGB，VEGF，CEA，CA19-9 and CA125 levels among the three groups before chemotherapy （P>0.05）.The levels of serum HGB，VEGF，CEA，CA19-9 and CA125 after chemotherapy were significantly lower than those before chemotherapy in the effective group （P<0.05）.There was no significant difference in the levels of serum HGB，VEGF，CEA，CA19-9 and CA125 before and after chemotherapy in the stable disease group （P>0.05）.There was no significant difference in the levels of serum HGB，VEGF，CEA and CA19-9 before and after chemotherapy in the progressive disease group （P>0.05）；but the level of serum CA125 after chemotherapy was significantly higher than that before chemotherapy （P<0.05）.The levels of serum HGB，VEGF，CEA，CA19-9 and CA125 in the effective group were significantly lower than those in the stable disease group and the progressive disease group after chemotherapy （P<0.05）.There was no significant difference in serum HGB，VEGF and CA19-9 levels between the stable disease group and the progressive disease group （P>0.05）；but the levels of serum CEA and CA125 in stable disease group were significantly lower than those in the progressive disease group after chemotherapy （P<0.05）.Multiple regression analysis showed that the changes of the levels of serum CEA，CA19-9，CA125 and VEGF were significantly correlated with the effect of chemotherapy （P<0.05）；the sequence of the correlation was CEA，CA19-9，CA125 and VEGF.There was no significant correlation between the serum HGB level and the effect of chemotherapy （P>0.05）.Conclusion　The changes of serum CEA，CA19-9，CA125 and VEGF levels were correlated with the effect of chemotherapy in patients with gastric cancer.Detecting serum CEA，CA19-9，CA125 and VEGF levels is helpful to predict the effect of chemotherapy.

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更新日期/Last Update: 2017-11-05