[1]李本亮,杨勇锋,张红星,等.成年早期起病精神分裂症患者脑白质弥散张量研究[J].新乡医学院学报,2017,34(11):974-977.[doi:10.7683/xxyxyxb.2017.11.005]
　LI Ben-liang,YANG Yong-feng,ZHANG Hong-xing,et al.Diffusion tensor imaging study of white matter fiber in patients with schizophrenia episode in early adulthood[J].Journal of Xinxiang Medical University,2017,34(11):974-977.[doi:10.7683/xxyxyxb.2017.11.005]
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成年早期起病精神分裂症患者脑白质弥散张量研究
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年11
页码:
974-977
栏目:
临床研究
出版日期:
2017-11-05

文章信息/Info

Title:
Diffusion tensor imaging study of white matter fiber in patients with schizophrenia episode in early adulthood
作者:
李本亮1; 杨勇锋1; 2; 张红星1; 3; 张海三1; 李文强2; 张　岱4; 吕路线1; 2
（1.新乡医学院第二附属医院精神科，河南　新乡　453002；2.河南省生物精神病学重点实验室，河南　新乡　453002；3.新乡医学院心理学系，河南　新乡　453003；4.北京大学第六医院精神科，北京　100191）
Author(s):
LI Ben-liang1; YANG Yong-feng1; 2; ZHANG Hong-xing1; 3; ZHANG Hai-san1; LI Wen-qiang2; ZHANG Dai4; LYU Lu-xian1; 2
（1.Department of Psychiatry，the Second Affiliated Hospital of Xinxiang Medical University，Xinxiang 453002，Henan Province，China；2.Henan Key Lab of Biological Psychiatry，Xinxiang 453002，Henan Province，China；3.Department of Psychology，Xinxiang Medical University，Xinxiang 453003，Henan Province，China；4.Department of Psychiatry，the Sixth Hospital of Peking University，Beijing 100191，China）
关键词:
成年早期起病; 精神分裂症; 脑白质; 弥散张量成像; 各向异性分数; 平均弥散率
Keywords:
schizophrenia; white matter; diffusion tensor imaging; fractional anisotropy; mean diffusivity
分类号:
R749.3
DOI:
10.7683/xxyxyxb.2017.11.005
文献标志码:
A
摘要:
目的　应用弥散张量成像（DTI）技术探究成年早期起病精神分裂症患者脑白质结构变化，为精神分裂症患者病理学研究提供结构性神经影像学依据。方法　选取2012年7月至2014年3月在新乡医学院第二附属医院住院的26例成年早期起病的精神分裂症患者为研究组，同期招募28例性别、年龄、利手情况及受教育程度与研究组相匹配的健康受试者为对照组，2组受试者均进行头颅结构像和DTI扫描。采用基于体素分析的方法比较2组受试者相同脑区白质各向异性（FA）及平均弥散率（MD）。结果　与对照组比较，研究组患者右侧扣带回前部、胼胝体膝部、右侧内囊前肢、双侧外囊、双侧放射冠后部及右侧放射冠前部等脑区 FA 降低（P<0.05）；研究组患者双侧内囊后肢、右侧放射冠上部、左侧上纵束、胼胝体及右侧扣带束等脑区MD显著高于对照组（P<0.05）。结论　成年早期起病精神分裂症患者存在多个脑区白质微结构损伤，这些改变可能与精神分裂症的病理改变相关。
Abstract:
Objective　To explore the structure changes of white matter of the patients with schizophrenia episode in early adulthood by diffusion tensor imaging（DTI） and in order to provide a structural neuroimaging basis for understanding the pathology of schizophrenia.Methods　Twenty-six patients with schizophrenia episode in early adulthood in the Second Affiliated Hospital of Xinxiang Medical University from July 2012 to March 2014 were selected as study group and twenty-eight healthy subjects whose age，sex，education were matched with study group were selected as control group.All subjects received structural magnetic resonance imaging and DTI scans.The fractional anisotropy （FA） and the mean diffusivity （MD） of the white matter of the same encephalic region were compared between the two groups by voxel-based analyses.Results　The FA values of the right anterior cingulate gyrusthe，genu of corpus callosum，the right limb of internal capsule，the bilateral external capsule，the bilateral posterior of coronal radiate，the right anterior coronal radiate of patients in the study group were significantly lower than those in the control group （P<0.05）.The MD values of the bilateral limbs of internal capsule，the right cingulate gyrus，left superior longitudinal tract，corpus callosum and right anterior coronal radiate of patients in the study group were significantly higher than those in the control group（P<0.05）.Conclusion　Schizophrenia patients who episode in early adulthood exist widespread microstructural damage of white matter.These changes may be related to the pathological change of schizophrenia.

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更新日期/Last Update: 2017-11-05