[1]王　波.血清基质金属蛋白酶组织抑制剂-1、胰岛素样生长因子-1和表皮生长因子水平检测在子宫肌瘤诊断中的价值[J].新乡医学院学报,2016,33(12):1098-1100.[doi:10.7683/xxyxyxb.2016.12.022]
　WANG Bo.Value of serum tissue inhibitor of matrix metalloproteinase-1,insulin like growth factor-1 and epidermal growth factor in the diagnosis of uterus myoma[J].Journal of Xinxiang Medical University,2016,33(12):1098-1100.[doi:10.7683/xxyxyxb.2016.12.022]
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血清基质金属蛋白酶组织抑制剂-1、胰岛素样生长因子-1和表皮生长因子水平检测在子宫肌瘤诊断中的价值
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年12
页码:
1098-1100
栏目:
临床研究
出版日期:
2016-12-05

文章信息/Info

Title:
Value of serum tissue inhibitor of matrix metalloproteinase-1,insulin like growth factor-1 and epidermal growth factor in the diagnosis of uterus myoma
作者:
王　波
（湖北省妇幼保健院妇科，湖北　武汉　430070）
Author(s):
WANG Bo
(Department of Gynecology,Hubei Maternal and Child Health Hospital,Wuhan 430070,Hubei Province,China)
关键词:
基质金属蛋白酶组织抑制剂-1; 胰岛素样生长因子-1; 表皮生长因子; 子宫肌瘤
Keywords:
tissue inhibitor of matrix metalloproteinase-1; insulin-like growth factor-1; epidermal growth factor; uterine myoma
分类号:
R737.33
DOI:
10.7683/xxyxyxb.2016.12.022
文献标志码:
A
摘要:
目的　探讨血清中基质金属蛋白酶组织抑制剂-1（TIMP-1）、胰岛素样生长因子-1（IGF-1）及表皮生长因子（EGF）水平检测在子宫肌瘤诊断中的价值。方法　选取2014年2月至2015年11月在湖北省妇幼保健院接受手术治疗的65例子宫肌瘤患者为子宫肌瘤组，其中黏膜下肌瘤27例（黏膜下肌瘤组），非黏膜下肌瘤38例（非黏膜下肌瘤组）；并选取同期体检健康女性57例为对照组。采用酶联免疫吸附试验测定受试者血清中TIMP-1、IGF-1和EGF水平；对各组受试者血清中TIMP-1、IGF-1及EGF水平进行比较，并分析血清中TIMP-1、IGF-1及EGF水平检测对子宫肌瘤诊断的价值。结果　子宫肌瘤组患者血清中TIMP-1、IGF-1和EGF水平显著高于对照组（P<0.01）。黏膜下肌瘤组患者血清中TIMP-1、IGF-1和EGF水平显著高于非黏膜下肌瘤组（P<0.01）。当TIMP-1取117.03 μg·L-1时对子宫肌瘤诊断的灵敏度为76.81%，特异度为90.23%；当IGF-1取582.04 μg·L-1时对子宫肌瘤诊断的灵敏度为46.36%，特异度为80.74%；当EGF取357.15 ng·L-1时对子宫肌瘤诊断的灵敏度为83.27%，特异度为51.26%；TIMP-1、EGF对子宫肌瘤诊断的灵敏度显著高于IGF-1（P<0.01），TIMP-1和EGF对子宫肌瘤诊断的灵敏度比较差异无统计学意义（P>0.05）。TIMP-1、IGF-1对子宫肌瘤诊断的特异度显著高于EGF（P<0.01），TIMP-1和IGF-1对子宫肌瘤诊断的特异度比较差异无统计学意义（P>0.05）。3项指标联合检测对子宫肌瘤诊断的灵敏度为93.47%，特异度为94.59%，3项指标联合检测对子宫肌瘤诊断的灵敏度显著高于TIMP-1和IGF-1（P<0.05），但与EGF对子宫肌瘤诊断的灵敏度比较差异无统计学意义（P>0.05）；3项指标联合检测对子宫肌瘤诊断的特异度显著高于IGF-1、EGF（P<0.05），但与TIMP-1对子宫肌瘤诊断的特异度比较差异无统计学意义（P>0.05）。结论　TIMP-1、IGF-1和EGF可作为诊断子宫肌瘤的血清学指标，3项指标联合检测对子宫肌瘤的诊断具有重要参考价值。
Abstract:
Objective　To investigate the value of serum tissue inhibitor of matrix metalloproteinase-1(TIMP-1),insulin like growth factor-1(IGF-1)and epidermal growth factor(EGF)in the diagnosis of uterus myoma.Methods　Sixty-five patients with uterus myoma who underwent operation in Hubei Maternal and Child Health Hospital from February 2014 to November 2015 were selected as uterus myoma group,and 57 cases of healthy women were selected as control group.Among the patients with uterus myoma,there were 27 cases of submucous myoma(submucous myoma group)and 38 cases of non-submucosal myoma(non-submucosal myoma group).The levels of serum TIMP-1,IGF-1 and EGF were detected by enzyme-linked immunosorbent assay.The levels of serum TIMP-1,IGF-1 and EGF were compared in the groups.The value of serum TIMP-1,IGF-1 and EGF levels in the diagnosis of uterine myoma was analyzed.Results　The levels of serum TIMP-1,IGF-1 and EGF in uterus myoma group were significantly higher than those in control group(P<0.01).The levels of serum TIMP-1,IGF-1 and EGF in submucous myoma group were significantly higher than those in non-submucous myoma group(P<0.01).When the TIMP-1 level was 117.03 μg·L-1,the sensitivity and specificity to the diagnosis of uterus myoma was 76.81% and 90.23% respectively.When the IGF-1 level was 582.04 μg·L-1,the sensitivity and specificity to the diagnosis of uterus myoma was 46.36% and 80.74% respectively.When the EGF level was 357.15 ng·L-1,the sensitivity and specificity to the diagnosis of uterus myoma was 83.27% and 51.26% respectively.The sensitivity of EGF and TIMP-1 to the diagnosis of uterus myoma was significantly higher than that of IGF-1(P<0.01),but there was no significant difference in the sensitivity of TIMP-1 and EGF in the diagnosis of uterus myoma(P>0.05).The specificity of TIMP-1 and IGF-1 to the diagnosis of uterus myoma was significantly higher than that of EGF(P<0.01),but there was no significant difference in the specificity of TIMP-1 and IGF-1 in the diagnosis of uterus myoma(P>0.05).The sensitivity and specificity of combined detection of the three indexes to the diagnosis of uterus myoma was 93.47% and 94.59% respectively.The sensitivity of combined detection of the three indexes to the diagnosis of uterus myoma was significantly higher than that of TIMP-1 and IGF-1(P<0.05),but there was no significant difference in the sensitivity of combined detection of the three indexes and EGF in the diagnosis of uterus myoma(P>0.05).The specificity of combined detection of the three indexes to the diagnosis of uterus myoma was significantly higher than that of IGF-1 and EGF(P<0.05),but there was no significant difference in the sensitivity of combined detection of the three indexes and TIMP-1 in the diagnosis of uterus myoma(P>0.05).Conclusion　TIMP-1,IGF-1 and EGF can be used as serological markers for diagnosis of uterus myoma;the combined detection of them has important reference value for the diagnosis of uterus myoma.

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更新日期/Last Update: 2016-12-05