[1]刘　焕,段瑞蒙,祝艺菡,等.瞬时受体电位香草酸亚型1在脑卒中神经损伤中的作用研究进展[J].新乡医学院学报,2016,33(12):1101-1104.[doi:10.7683/xxyxyxb.2016.12.023]
　LIU Huan,DUAN Ruimeng,ZHU Yihan,et al.Research Progress on the role of vanillic acid subtype 1 of transient receptor potential in nerve injury after stroke[J].Journal of Xinxiang Medical University,2016,33(12):1101-1104.[doi:10.7683/xxyxyxb.2016.12.023]
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瞬时受体电位香草酸亚型1在脑卒中神经损伤中的作用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年12
页码:
1101-1104
栏目:
综述
出版日期:
2016-12-05

文章信息/Info

Title:
Research Progress on the role of vanillic acid subtype 1 of transient receptor potential in nerve injury after stroke
作者:
刘　焕; 段瑞蒙; 祝艺菡; 李超堃; 江林华; 李东亮
(新乡医学院基础医学院生理学与神经生物学教研室，河南　新乡　453003)
Author(s):
LIU Huan; DUAN Ruimeng; ZHU Yihan; LI Chaokun; JIANG Linhua; LI Dongliang
关键词:
瞬时受体电位香草酸亚型1; 辣椒素; 内源性大麻素; 脑血管血流; 低温; 自噬
分类号:
R743
DOI:
10.7683/xxyxyxb.2016.12.023
文献标志码:
A
摘要:
脑卒中具有高致残率、高致死率，严重威胁着人类社会的健康水平，且近年来有上升趋势。利用组织型纤溶酶原激活剂进行溶栓治疗是缺血性脑卒中最有效的治疗措施，然而脑卒中超过3 h后治疗效果不佳，此外，再灌注可引起更加严重的继发性脑损伤。目前，有关瞬时受体电位香草酸亚型1(TRPV1)在脑神经系统损伤中发挥的作用受到越来越多学者的关注，有望成为脑神经损伤的干预靶点之一。但该通道在脑神经损伤中的具体作用及其机制仍需进一步探讨。本文主要从TRPV1的结构及分布，TRPV1激活剂对脑缺血缺氧后神经功能的作用，TRPV1对脑血管血流的调节，TRPV1激活诱发的低温、自噬对脑卒中后脑神经细胞活力的影响以及TRPV1与内源性大麻素及其受体之间相互作用的机制加以阐述，旨在揭示TRPV1在脑卒中病理进程中的潜在作用，为脑卒中的治疗及研究提供新的思路。

参考文献/References:

［1］　ZHANG L，FANG G，ZHENG L，et al.The hypocholesterolemic effect of capsaicinoids in ovariectomized rats fed with a cholesterol-free diet was mediated by inhibition of hepatic cholesterol synthesis［J］.Food Funct，2013，4(5):738-744.
［2］　ZSOMBOK A.Vanilloid receptors：do they have a role in whole body metabolism? Evidence from TRPV1［J］.J Diabetes Complications，2013，27(3):287-292.
［3］　MA L，ZHONG J，ZHAO，Z，et al.Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis［J］.Cardiovasc Res，2011，92(3):504-513.
［4］　LIAO M，CAO E，JULIUS D，et al.Structure of the TRPV1 ion channel determined by electron cryo-microscopy［J］.Nature，2013，504(7478):107-112.
［5］　BEVAN S，QUALLO T，ANDERSSON D A.TRPV1［J］.Handb Exp Pharmacol，2014，222(3):207-245.
［6］　LISHKO P V，PROCKO E，JIN X，et al.The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity［J］.Neuron，2007，54(6):905-918.
［7］　CRISTINO L，DE PETROCELLIS L，PRYCE G，et al.Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain［J］.Neuroscience，2006，139(4):1405-1415.
［8］　ZHANG E，LIAO P.Brain transient receptor potential channels and stroke［J］.J Neurosci Res，2015，93(8):1165-1183.
［9］　KHATIBI N H，JADHAV V，CHARLES S，et al.Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats［J］.Acta Neurochir Suppl，2011，111:225-230.
［10］　SAKAMOTO K，KUROKI T，OKUNO Y，et al.Activation of the TRPV1 channel attenuates N-methyl-D-aspartic acid-induced neuronal injury in the rat retina ［J］.Eur J Pharmacol，2014，733 (3):13-22.
［11］　SHIRAKAWA H，YAMAOKA T，SANPEI K，et al.TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons［J］.Biochem Biophys Res Commun，2008，377(4):1211-1215.
［12］　MARINELL S，VAUGHAN C W，CHRISTIE M J，et al.Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro［J］.J Physiol，2002，543(Pt 2):531-540.
［13］　NACCARATO M，PIZZUTI D，PETROSINO S.Possible anandamide and palmitoylethanolamide involvement in human stroke［J］.Lipids Health Dis，2010，9(1):47.
［14］　LU T S，AVRAHAM H K，SENG S，et al.Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells［J］.J Immunol，2008，181(9):6406-6416.
［15］　GRABIEC U，KOCH M，KALLENDRUSCH S，et al.The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB1)［J］.Neuropharmacology，2012，62(4):1797-1807.
［16］　KIM S R，BOK E，CHUNG Y C，et al.Interactions between CB1 receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons［J］.Br J Pharmacol，2008，155(2):253-264.
［17］　HWANG S W，CHO H，KWAK J，et al.Direct activation of capsaicin receptors by products of lipoxygenases:endogenous capsaicin-like substances［J］.Proc Natl Acad Sci USA，2000，97(11):6155-6160.
［18］　KIM S R，CHUNGH Y C，CHUNG E S，et al.Roles of transient receptor potential vanilloid subtype 1 and cannabinoid type 1 receptors in the brain:neuroprotection versus neurotoxicity［J］.Mol Neurobiol，2007，35(3):245-254.
［19］　YANG D，LUO Z，MA S，et al.Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension［J］.Cell Metab，2010，12(2):130-141.
［20］　苏立男.TRPVl对内皮细胞增殖、迁移能力的影响及相关机制［D］.泸州:四川医科大学，2015.
［21］　XU X，WANG P，ZHAO Z，et al.Activation of transient receptor potential vanilloid 1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats［J］.Stroke，2011，42(11):3245-3251.
［22］　CHING L C，CHEN C Y，SU K H，et al.Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase［J］.Mol Med，2012，18(5):805-815.
［23］　徐兴森.激活TRPV1预防动脉粥样硬化及脑卒中的机制研究［D］.重庆:第三军医大学，2012.
［24］　ZHANG M J，YIN Y W，LI B H，et al.The role of TRPV1 in improving VSMC function and attenuating hypertension［J］.Prog Biophys Mol Biol，2015，117(2/3):212-216.
［25］　CAO Z J，BALASUBRAMANIAN A，MARRELLI S P.Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion［J］.Am J Physiol Regul Integr Comp Physiol，2014，306(2):R149-R156.
［26］　岳静，陈雯，向桂芳，等.通过激活TRPV1达到快速有效治疗性浅低温方法的探讨［J］.中国病理生理杂志，2015，31(9):1633-1636.
［27］　MUZZI M，FELICI R，CAVONE L，et al.Ischemic neuroprotection by TRPV1 receptor-induced hypothermia［J］.J Cereb Blood Flow Metab，2012，32(6):978-982.
［28］　黎炳护.激活TRPV1诱导自噬在血管平滑肌细胞泡沫化中作用及机制研究［D］.重庆:第三军医大学，2015.
［29］　FARFARIELLO V，AMANTINI C，SANTONI G.Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways［J］.J Leukoc Biol，2012，92(3):421-431.
［30］　LIU A J，WANG S H，HOU S Y，et al.Evodiamine induces transient receptor potential vanilloid-1-mediated protective autophagy in U87-MG astrocytes［J］.Evid Based Complement Alternat Med，2013,2013:354840.doi:10.1155/2013/354840.
［31］　WANG Z，SUN L，YU H.Binding mode pediction of evodiamine within vanilloid receptor TRPV1［J］.Int J Mol Sci，2012，13(7):8958-8969.
［32］　HALE A N，LEDBETTER D J，GAWRILUK T R，et al.Autophagy:regulation and role in development［J］.Autophagy，2013，9(7):951-972.
［33］　DONG W，XIAO S，CHENG M，et al.Minocycline induces protective autophagy in vascular endothelial cells exposed to an in vitro model of ischemia/reperfusion-induced injury［J］.Biomed Rep，2016，4(2):173-177.
［34］　毛光兰，贾奎 ． 加味补阳还五汤联合针刺养老穴治疗脑卒中后肩-手综合征疗效观察［J］.新乡医学院学报，2015，32(1):62-64.
［35］　MIYANOHARA J，SHIRAKAWA H，SANPEI K，et al.A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice［J］.Biochem Biophys Res Commun，2015，467(3):478-483.
［36］　HU D E，EASTON A S，FRASER P A.TRPV1 activation results in disruption of the blood-brain barrier in the rat［J］.Br J Pharmacol，2005，146(4):576-584.
［37］　ZHENG Y，HOU J，LIU J，et al.Inhibition of autophagy contributes to melatonin-mediated neuroprotection against transient focal cerebral ischemia in rats［J］.J Pharmacol Sci，2014，124(3):354-364.

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更新日期/Last Update: 2016-12-05