[1]孟庆军,孟　磊,金保哲,等.依达拉奉联合亚低温治疗重型颅脑损伤临床疗效分析[J].新乡医学院学报,2016,33(11):963-966.[doi:10.7683/xxyxyxb.2016.11.007]
　MENG Qing-jun,MENG Lei,JIN Bao-zhe,et al.Curative effect of edaravone combined with mild hypothermia in treatment of severe craniocerebral injury[J].Journal of Xinxiang Medical University,2016,33(11):963-966.[doi:10.7683/xxyxyxb.2016.11.007]
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依达拉奉联合亚低温治疗重型颅脑损伤临床疗效分析
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年11
页码:
963-966
栏目:
临床研究
出版日期:
2016-11-05

文章信息/Info

Title:
Curative effect of edaravone combined with mild hypothermia in treatment of severe craniocerebral injury
作者:
孟庆军1; 孟　磊2; 金保哲2; 时会敏1; 周文科2
（1.郑州市第一人民医院神经外科，河南　郑州　450000；2.新乡医学院第一附属医院神经外科，河南　卫辉　453100）
Author(s):
MENG Qing-jun1; MENG Lei2; JIN Bao-zhe2; SHI Hui-min1; ZHOU Wen-ke2
（1.Department of Neurosurgery,the First People′s Hospital of Zhengzhou,Zhengzhou 450000，Henan Province,China;2.Department of Neurosurgery,the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province,China）
关键词:
重型颅脑损伤; 依达拉奉; 亚低温治疗
Keywords:
severe craniocerebral injury; edaravone; mild hypothermia
分类号:
R651.1+5
DOI:
10.7683/xxyxyxb.2016.11.007
文献标志码:
A
摘要:
目的　探讨依达拉奉注射液联合头颅局部亚低温治疗重型颅脑损伤的临床疗效。方法　将200例重型颅脑损伤患者随机分为对照组和观察组，每组100例。对照组患者给予常规药物和对症处理，观察组患者在对照组治疗基础上加用依达拉奉注射液联合头颅局部亚低温治疗，比较2组患者入院当天或急诊术后以及入院后4、7、14 d的格拉斯哥昏迷（GCS）评分和脑水肿变化情况;患者出院当天格拉斯哥预后功能（GOS）评分以及随访3个月时远期生活质量评估（KPS）得分。结果　对照组患者治疗过程中死亡13例（13%），观察组死亡6例（6%），观察组患者病死率显著低于对照组（P<0.05）；2组患者入院当天或急诊术后GCS评分比较差异无统计学意义（P>0.05），入院后4、7、14 d GCS评分观察组患者显著高于对照组（P<0.05）；2组患者入院当天或急诊术后以及入院后4、7、14 d相邻2次测定颅脑水肿面积的差值比较差异均有统计学意义（P<0.05）,且观察组显著优于对照组（P<0.05）；出院当天观察组和对照组患者GOS评分分别为4.45±0.57、3.99±0.64，观察组患者GOS评分显著高于对照组（P<0.05）；出院后3个月，观察组和对照组患者KPS得分分别为93.24±5.89、81.41±6.72，观察组患者KPS得分显著高于对照组（P<0.05）。结论　依达拉奉注射液联合头颅局部亚低温治疗重型颅脑损伤有显著的脑保护作用。
Abstract:
Objective　To explore the clinical curative effect of edaravone combined with mild hypothermia in treatment of acute severe craniocerebral injury.Methods　Two hundred patients with severe craniocerebral injury were divided into control group and observation group by random digits table,with 100 patients in each group.The patients in control group were given conventional drugs and symptomatic treatment;based on these,the patients in observation group were treated with edaravone combined with mild hypothermia.The Glasgow coma scale(GCS) scores and brain edema change situation of patients at admission day or after emergency operation and 4,7,14 d after hospitalization were compared between the two groups;the Glasgow outcome scale（GOS） scores of patients at discharged the day from hospital and long-term karnofsky performance scale（KPS） scores of patients after following-up 3 months were recorded and compared between the two groups.Results　Thirteen patients(13%)in the control group and 6 patients in the observation group（6%） died during the treatment;the mortality rate of patients in the observation group was significantly lower than that in the control group (P<0.05).There was no significant difference in GCS scores of patients on admission day or after emergency operation between the two groups（P>0.05）;but the GCS scores of patients in the observation group at 4,7,14 d after hospitalization were significantly higher than those in the control group (P<0.05).The cerebral edema fluctuation area of patients in the observation group at admission day or after emergency operation and 4,7,14 d after hospitalization was significantly lower than that in the control group (P<0.05).The GOS score of patients at discharged the day in the observation group and control group was 4.45±0.57 and 3.99±0.64 respectively;there was statistic difference of GOS score between the two groups（P<0.05）.The KPS score of patients after following-up for 3 months in observation group and control group was 93.24±5.89 and 81.41±6.72 respectively;the KPS score of patients in the observation group was significantly higher than that in the control group (P<0.05).Conclusion　Edaravone injection combined with local mild hypothermia have a conspicuous neuroprotective effect in treatment of severe craniocerebral injury.

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更新日期/Last Update: 2016-11-05