[1]王海涛,王锦波.重型脑损伤患者早期肝肾功能变化临床研究[J].新乡医学院学报,2016,33(5):421-424.[doi:10.7683/xxyxyxb.2016.05.021]
　WANG Hai-tao,WANG Jin-bo.Clinical studies on early changes of liver and kidney function in severe brain injury[J].Journal of Xinxiang Medical University,2016,33(5):421-424.[doi:10.7683/xxyxyxb.2016.05.021]
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重型脑损伤患者早期肝肾功能变化临床研究
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年5
页码:
421-424
栏目:
临床研究
出版日期:
2016-05-05

文章信息/Info

Title:
Clinical studies on early changes of liver and kidney function in severe brain injury
作者:
王海涛1; 2; 王锦波3
（1.新乡医学院，河南　新乡　453003；2.舞阳县人民医院脑外脊柱科，河南　舞阳　462400；3.中国人民解放军371中心医院肝胆外科，河南　新乡　453000）
Author(s):
WANG Hai-tao1; 2; WANG Jin-bo3
(1.Xinxiang Medical University，Xinxiang 453003，Henan Province，China；2.Department of Spinal and Brain Surgery,the Hospital of Wuyang County,Wuyang 462400,Henan Province,China;3.Department of Hepatobiliary Surgery，the 371st Central Hospital of PLA，Xinxiang 453000，Henan Province，China)
关键词:
重型脑损伤; 肝功能; 肾功能
Keywords:
severe brain injury; liver function; kidney function
分类号:
R651.1+5
DOI:
10.7683/xxyxyxb.2016.05.021
文献标志码:
A
摘要:
目的　探讨格拉斯哥昏迷评分(GCS) ≤8分的危重脑损伤患者早期的肝、肾功能变化及对预后的影响。方法　统计分析舞阳县人民医院2014年10月至2015年4月收治的32例GCS评分≤8分的危重脑损伤患者的临床资料，分析其入院时及入院后第1、2、3、5天丙氨酸氨基转氨酶（ALT）、天冬氨酸氨基转氨酶（AST）、血清肌酐（Scr）和尿素氮（BUN）水平的变化，并根据患者预后分为生存组和死亡组对上述指标进行统计学分析。结果　本组32例患者，存活14例（生存组），死亡18例（死亡组）。死亡组患者年龄高于生存组（P<0.05）。2组患者入院时及入院后第1、2、3、5天ALT和AST水平比较差异均无统计学意义（P>0.05）。生存组患者入院后第5天ALT水平高于入院后第2天（P<0.05）。死亡组患者入院后第3、5天BUN水平高于入院时及入院后第1天（P<0.05），入院后第5天Scr水平高于入院时和入院后第1天（P<0.05）。生存组患者入院后第2、3、5天的BUN水平低于死亡组（P<0.05），入院后第3、5天Scr水平低于死亡组（P<0.05）。结论　通过观察重症脑损伤患者肝、肾功能可及早调整相关治疗，有利于病情转归。
Abstract:
Objective　To investigate the changes of early liver function and kidney function in severe traumatic brain injury patients with the Glasgow coma score(GCS) ≤8 points and the impact on the prognosis.Methods　The data of thirty-two patients with GCS score ≤8 points of Wuyang County People′s Hospital from October 2014 to April 2015 were analysed.The changes of alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，blood urea nitrogen(BUN) and serum creatinine(Scr) at the time of being admitted to hospital，on the first day，the second day，the third day and the fifth day after their admission were analysed.Then the patients were divided into survival group and the death group according to the prognosis，and the changes of ALT，AST，BUN and Scr were analysed.Results　Of the 32 patients，14 patients survived（survival group），18 patients died(death group).The age of death group was higher than that of survival group （P<0.05）.There was no significant difference in ALT and AST at the time of being admitted to hospital，on the first day，the second day，the third day and the fifth day after their admission（P>0.05）.The level of ALT in survival group on the fifth day after admission was higher than that on the second day after admission（P<0.05）.In death group，the level of BUN on the third day and the fifth day after admission was higher than that at the time of being admitted to hospital and on the first day after admission（P<0.05），the level of Scr on the fifth day was higher than that at the time of being admitted to hospital and on the first day after admission（P<0.05）.The level of BUN in survival group on the second，third and fifth day was lower than that in death group（P<0.05），while the level of Scr on the third and fifth day after admission was lower than that in death group（P<0.05）.Conclusion　By observing liver function，kidney function variation curve can adjust the treatment as soon as possible，it is conducive to disease outcome.

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更新日期/Last Update: 2016-05-05