[1]李亚萍,张俊林.复方甘草酸苷治疗慢性重型乙型肝炎的疗效和安全性[J].新乡医学院学报,2016,33(1):045-47.[doi:10.7683/xxyxyxb.2016.01.013]
　LI Ya-ping,ZHANG Jun-lin.Effect and safety of compound glycyrrhizin on chronic severe hepatitis B[J].Journal of Xinxiang Medical University,2016,33(1):045-47.[doi:10.7683/xxyxyxb.2016.01.013]
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复方甘草酸苷治疗慢性重型乙型肝炎的疗效和安全性
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年1
页码:
045-47
栏目:
临床研究
出版日期:
2016-01-05

文章信息/Info

Title:
Effect and safety of compound glycyrrhizin on chronic severe hepatitis B
作者:
李亚萍1; 张俊林2
（1.黄冈市中心医院感染科，湖北　黄冈　438000；2.深圳市中海医院急诊科，广东　深圳　518112）
Author(s):
LI Ya-ping2; ZHANG Jun-lin2
(1.Department of Infectious Diseases，Huanggang Central Hospital，Huanggang 438000，Hubei Province，China；2.Department of Emergency，Zhonghai Hospital of Shenzhen City，Shenzhen 518112，Guangdong Province，China)
关键词:
慢性重型乙型肝炎; 肝纤维化; 肝功能; 安全性; 复方甘草酸苷
Keywords:
chronic severe hepatitis B; liver fibrosis; liver function; safety; compound glycyrrhizin
分类号:
R512.6
DOI:
10.7683/xxyxyxb.2016.01.013
文献标志码:
A
摘要:
目的　探讨复方甘草酸苷治疗慢性重型乙型肝炎的临床效果和安全性。方法　92例慢性重型乙型肝炎患者分为观察组和对照组，每组46例，对照组患者给予常规治疗，观察组患者在常规治疗基础上给予复方甘草酸苷 2～3片，每日3次，饭后口服，连续治疗1 a。对2组患者的肝功能指标、肝纤维化指标、不良反应发生率及临床疗效进行比较。结果　治疗前2组患者血清丙氨酸氨基转移酶(ALT)、总胆红素（TBIL）、天门冬氨酸氨基转移酶(AST)及血浆白蛋白（ALB）水平比较差异均无统计学意义（P>0.05）；治疗后观察组患者血清ALT、TBIL及AST水平显著低于对照组（P<0.05），ALB水平显著高于对照组（P<0.05）。治疗前2组患者血清透明质酸（HA）、层黏连蛋白（LN）、Ⅲ型前胶原（PC-Ⅲ）及Ⅳ型胶原（Ⅳ-C)水平比较差异均无统计学意义（P>0.05）；治疗后观察组患者血清HA、LN、PC-Ⅲ 及Ⅳ-C水平显著低于对照组（P<0.05）。观察组患者治疗有效率和疾病控制率分别为71.74%（33/46）和93.48%（43/46），对照组患者治疗有效率和疾病控制率分别为50.00%（23/46）和76.09%（35/46），观察组患者治疗有效率和疾病控制率显著高于对照组（P<0.05）。对照组和观察组患者不良反应发生率分别为13.04%（6/46）和8.70%（4/46），2组比较差异无统计学意义（P>0.05）。结论　复方甘草酸苷治疗慢性重型乙型肝炎可以有效改善患者肝纤维化和肝功能，控制疾病进展。
Abstract:
Objective　To investigate the clinical effect and safety of compound glycyrrhizin on chronic severe hepatitis B.Methods　A total of 92 cases of chronic severe hepatitis B were divided into observation group and control group，46 cases in each group.The patients in control group were treated with conventional treatment.Based on the conventional treatment，the patients in observation group were treated with compound glycyrrhizin 2-3 tablets by oral after meals，three times a day for one year.The liver function index，liver fibrosis index，incidence of adverse reaction and clinical effect were compared between the two groups.Results　There was no significant difference in the levels of serum alanine transarninase(ALT)，total bilirubin(TBIL)，aspartate aminotransferase(AST) and plasma albumin(ALB) between the two groups before treatment(P>0.05).The levels of serum ALT，TBIL and AST in observation group were significantly lower than those in control group after treatment(P<0.05).The level of plasma ALB in observation group was significantly higher than that in control group after treatment(P<0.05).There was no significant difference in the levels of serum hexadecenoic acid(HA)，laminin(LN)，precollagen type Ⅲ(PC-Ⅲ) and collagen type Ⅳ(Ⅳ-C) between the two groups before treatment(P>0.05).The levels of serum HA，LN，PC-Ⅲ and Ⅳ-C in observation group were significantly lower than those in control group after treatment(P<0.05).The effective rate and control rate in observation group were 71.74%(33/46) and 93.48%(43/46)，which in control group were 50.00%(23/46) and 76.09% (35/46).The effective rate and control rate in observation group were significantly higher than those in control group(P<0.05).The incidence of adverse reaction in control group and observation group was 13.04%(6/46) and 8.70%(4/46) respectively，and there was no significant difference between the two groups(P>0.05).Conclusion　Compound glycyrrhizin for treating chronic severe hepatitis B can effectively improve the patients′ liver fibrosis and liver function，control the progression of disease.

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更新日期/Last Update: 2016-01-05