[1]晏　菲,马燕凌,邓　洁,等.后肾腺瘤16例临床病理观察[J].新乡医学院学报,2016,33(1):034-36.[doi:10.7683/xxyxyxb.2016.01.010]
　YAN Fei,MA Yan-ling,DENG Jie,et al.Clinical and pathological characteristics of metanephric adenoma：a report of 16 cases[J].Journal of Xinxiang Medical University,2016,33(1):034-36.[doi:10.7683/xxyxyxb.2016.01.010]
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后肾腺瘤16例临床病理观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
33
期数:
2016年1
页码:
034-36
栏目:
临床研究
出版日期:
2016-01-05

文章信息/Info

Title:
Clinical and pathological characteristics of metanephric adenoma：a report of 16 cases
作者:
晏　菲; 马燕凌; 邓　洁; 刘　莉; 孙建海
（湖北省中山医院肿瘤科，湖北　武汉　430000）
Author(s):
YAN Fei; MA Yan-ling; DENG Jie; LIU Li; SUN Jian-hai
（Department of Oncology，Zhongshan Hospital in Hubei Province，Wuhan 430030，Hubei Province，China）
关键词:
后肾腺瘤; 临床病理; 免疫组织化学; 鉴别诊断
Keywords:
metanephric adenoma; clinical-pathological; immunohistochemistry; differential diagnosis
分类号:
R737.11
DOI:
10.7683/xxyxyxb.2016.01.010
文献标志码:
A
摘要:
目的　探讨后肾腺瘤(MA)的临床病理学特征。方法　回顾性分析16例MA患者的临床特点及病理学大体形态特征。MA组织常规行苏木精-伊红染色，应用免疫组织化学染色法检测波形蛋白（Vim）、CD57、肾母细胞瘤蛋白1（WT-1）、细胞角蛋白7（CK7）、嗜铬素A(CgA)、突触素（Syn）及CD10在MA组织中的表达。结果　本组16例MA患者，男6例，女10例。影像学检查表现为边界清楚的低密度影。肉眼观肿瘤边界清楚，呈灰白或灰黄色，质地稍硬；镜下肿瘤细胞排列密集，肿瘤细胞小且均匀一致，呈小腺泡状或乳头状结构，并可见砂砾体钙化。免疫组织化学染色结果显示，MA组织中CD57和Vim均呈阳性；WT-1阳性13例，灶性阳性1例，阴性2例；CK7阴性13例，阳性3例；而CgA、Syn灶性阳性各1例，CD10均为阴性表达。Ki-67标记指数小于5%。结论　MA具有相对特征性的病理形态学特征，免疫标记常表达CD57，综合二者考虑有助于与肾脏其他肿瘤如肾细胞癌和肾母细胞瘤鉴别。
Abstract:
Objective　To explore the clinical and histopathological features of metanephric adenoma (MA).Methods　Sixteen MA cases were retrospectively recruited to analyze their clinical characteristic and pathological morphological characteristic in general.The MA tissue was stained by haematoxylin and eosin and immunohistochemistry staining was used to detect the expression of vimentin(Vim)，CD57，Wilms′ tumor-1(WT-1)，cytokeratin 7(CK7)，chromogramin A(CgA)，synaptopbysin(Syn) and CD10.Results　There were 6 male and 10 female in the 16 MA patients.The tumor showed low density with a distinct boundary by imaging.Macroscopically，it had a clear edge with grey or yellow or tan cut surface and moderate texture.Microscopically，the tumors were composed of benign dense small and cuboidual epithelial cells with scant cytoplasm.They presented as aciniform or papillary arrangement.Psammoma bodies could be found in some cases.Immunohistochemical staining showed the tumor cells were positive for Vim，CD57 in all cases，and positive for WT-1 in most cases(13 cases)，but negative for CK7 13 cases and positive partly in 3 cases，CgA and Syn were positive partly in 1 case,and CD10 in all cases were negatively expression.Ki-67 proliferation index was less than 5%.Conclusion　It is helpful for diagnosis to master its clinical and histopathological characteristics of the MA,whose CD57 is positive staining， which can be differentiated from other renal tumors including renal carcinoma and WT.

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更新日期/Last Update: 2016-01-05