[1]孙宣锋,曹慧霞,焦晓静,等.糖原合成激酶-3β通过上皮间充质转化参与糖尿病肾病发生发展的研究进展[J].新乡医学院学报,2024,(1):077-81.[doi:10.7683/xxyxyxb.2024.01.014]
　SUN Xuanfeng,CAO Huixia,JIAO Xiaojing,et al.Research progress of glycogen synthesis kinase-3β in the development of diabetic nephropathy[J].Journal of Xinxiang Medical University,2024,(1):077-81.[doi:10.7683/xxyxyxb.2024.01.014]
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糖原合成激酶-3β通过上皮间充质转化参与糖尿病肾病发生发展的研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
期数:
2024年1
页码:
077-81
栏目:
综述
出版日期:
2024-01-05

文章信息/Info

Title:
Research progress of glycogen synthesis kinase-3β in the development of diabetic nephropathy
作者:
孙宣锋; 曹慧霞; 焦晓静; 张丽娜; 阎磊; 邵凤民
（郑州大学人民医院肾内科/河南省肾脏病免疫重点实验室，河南　郑州　450003）
Author(s):
SUN Xuanfeng; CAO Huixia; JIAO Xiaojing; ZHANG Lina; YAN Lei; SHAO Fengmin
（Department of Nephrology,People′s Hospital of Zhengzhou University,Henan Key Laboratory of Renal Immunization,Zhengzhou 450003,Henan Province,China）
关键词:
糖原合成激酶-3β; 糖尿病肾病; 上皮间充质转化; 信号通路
Keywords:
glycogen synthesis kinase-3β; diabetic nephropathy; epithelial-mesenchymal transition; signaling pathways
分类号:
R692
DOI:
10.7683/xxyxyxb.2024.01.014
文献标志码:
A
摘要:
糖尿病肾病（DN）是糖尿病重要的并发症之一，发病机制复杂，目前尚未完全阐明。上皮间充质转化（EMT）在DN的发生发展中发挥重要作用。糖原合成激酶-3β（GSK-3β）通过多个信号转导通路参与EMT过程，影响DN的发生进展。本文就GSK-3β参与DN中EMT的相关机制研究进展进行综述。
Abstract:
Diabetic nephropathy (DN) is one of the most important complications of diabetes.Its pathogenesis is complex and has not been fully elucidated.Epithelial-mesenchymal transition (EMT) plays an important role in the development of DN.Relevant data show that glycogen synthesis kinase-3β (GSK-3β) participates in the process of EMT through multiple signaling pathways and affects the occurrence and progression of DN.This article reviews the research progress of GSK-3β involved in EMT in DN.

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更新日期/Last Update: 2024-01-05