[1]徐筱雅,刘尚明,张爱霞.微管靶向药物抗肿瘤侵袭转移潜力研究进展[J].新乡医学院学报,2023,40(2):196-200.[doi:10.7683/xxyxyxb.2023.02.019]
　XU Xiaoya,LIU Shangming,ZHANG Aixia.Research progress on the potential of microtubule targeting agents in anti-tumor invasion and metastasis[J].Journal of Xinxiang Medical University,2023,40(2):196-200.[doi:10.7683/xxyxyxb.2023.02.019]
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微管靶向药物抗肿瘤侵袭转移潜力研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
40卷
期数:
2023年2期
页码:
196-200
栏目:
综述
出版日期:
2023-02-05

文章信息/Info

Title:
Research progress on the potential of microtubule targeting agents in anti-tumor invasion and metastasis
作者:
徐筱雅; 刘尚明; 张爱霞
（南京医科大学药学院，江苏　南京　211166）
Author(s):
XU Xiaoya; LIU Shangming; ZHANG Aixia
(School of Pharmacy,Nanjing Medical University,Nanjing 211166,Jiangsu Province,China)
关键词:
微管靶向药物; 肿瘤; 侵袭; 转移; 信号通路
Keywords:
microtubule targeting agents; tumor; invasion; metastasis; signal pathway
分类号:
R73
DOI:
10.7683/xxyxyxb.2023.02.019
文献标志码:
A
摘要:
恶性肿瘤是一类严重危害人们生命和健康的重大疾病。目前，传统的抗肿瘤治疗在靶向性杀伤原发肿瘤细胞上展现出一定的优势，但针对肿瘤转移这一亟待解决的难题仍未有明显突破，因此，探索新型抗肿瘤转移药物对改善肿瘤的治疗效果具有重要意义。微管在真核细胞有丝分裂、信号转导、细胞器运输、细胞运动等多种生理过程中的重要作用，使其成为抗肿瘤药物的重要研究靶点。新近的研究证明，一些微管靶向药物（MTAs）不仅对肿瘤细胞具有抑制增殖、诱导凋亡的作用，还能在亚致死剂量下显著抑制肿瘤细胞的迁移与侵袭，这为解决此类药物的剂量限制性毒性提供了可能，从而使其更加有效地发挥抗肿瘤作用。本文就MTAs在抗肿瘤侵袭转移中的作用及相关机制的研究进展进行综述，旨在为开发MTAs在临床抗肿瘤治疗中新的应用潜能提供新思路。
Abstract:
Malignant tumor is a kind of serious disease that seriously endangers people′s life and health.At present,the traditional anti-tumor therapy has shown some advantages in targeted killing of primary tumor cells,but there is still no obvious breakthrough in tumor metastasis.Therefore,it is of great significance to explore new anti-tumor metastasis drugs for improving the therapeutic effect of tumors.Microtubule has gradually become an important research target of antitumor drugs due to its important role in many physiological processes,such as eukaryotic mitosis,signal transduction,organelle transport,cell movement,and so on.Recent studies have proved that some microtubule targeting agents (MTAs) can not only inhibit the proliferation and induce apoptosis of tumor cells,but also significantly inhibit the migration and invasion of tumor cells at a sublethal dose,this provides a possibility to avoide the dose limiting toxicity of such drugs,so that they can play a more effective anti-tumor role.This paper reviews the research progress of effect and related mechanism of MTAs in anti-metastasis,in order to provide new ideas for developing new application potential of MTAs in clinical anti-tumor therapy.

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更新日期/Last Update: 2023-02-05