[1]周莉莉,刘 佳,张晓艳.罗沙司他治疗肾性贫血的作用机制及临床研究进展[J].新乡医学院学报,2021,38(5):488-492.[doi:10.7683/xxyxyxb.2021.05.020]
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罗沙司他治疗肾性贫血的作用机制及临床研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年5
页码:
488-492
栏目:
综述
出版日期:
2021-05-05

文章信息/Info

作者:
周莉莉1刘 佳1张晓艳2
(1.长治医学院,山西 长治 046000;2.长治医学院附属和平医院肾内科,山西 长治 046000)
关键词:
罗沙司他低氧诱导因子脯氨酰羟化酶抑制剂肾性贫血
分类号:
R973
DOI:
10.7683/xxyxyxb.2021.05.020
文献标志码:
A
摘要:
肾性贫血为慢性肾脏病(CKD)患者肾功能失代偿期主要并发症之一,其患病率和严重程度随着CKD的进展逐渐增加。贫血可增加CKD患者心血管疾病的发生率和死亡风险。罗沙司他是全球首个用于治疗肾性贫血的小分子低氧诱导因子脯氨酰羟化酶抑制剂类药物,其可抑制低氧诱导因子(HIF)的降解,增加红细胞生成素的表达,改善铁吸收、转运和利用,调控红细胞生成,达到纠正CKD患者贫血的目的。与以往用于纠正贫血的药物红细胞生成刺激剂及铁剂相比,人体对罗沙司他的耐受性良好,目前完成的临床研究未见其引起严重不良反应、加重心血管事件的风险。本文就罗沙司他通过稳定HIF纠正肾性贫血的作用机制及临床研究进展作一综述。

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更新日期/Last Update: 2021-05-05