[1]王寅彪,冯继伟,陈礼朋,等.2′-5′寡聚腺苷酸合成酶的抗病毒作用及机制研究进展[J].新乡医学院学报,2021,38(5):485-487.[doi:10.7683/xxyxyxb.2021.05.019]
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2′-5′寡聚腺苷酸合成酶的抗病毒作用及机制研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
38
期数:
2021年5
页码:
485-487
栏目:
综述
出版日期:
2021-05-05

文章信息/Info

作者:
王寅彪1冯继伟1陈礼朋2宋 杰1吴卫东1
(1.新乡医学院公共卫生学院,河南 新乡 453003;2.固始县动物疫病预防控制中心,河南 信阳 465200)
关键词:
2′-5′寡聚腺苷酸合成酶双链核糖核酸活化机制抗病毒作用病毒逃逸
分类号:
Q291
DOI:
10.7683/xxyxyxb.2021.05.019
文献标志码:
A
摘要:
2′-5′寡聚腺苷酸合成酶(OAS)是干扰素诱导产生的重要抗病毒蛋白,可利用细胞内游离的三磷腺苷合成2′,5′-磷酸二酯键连接的寡聚腺苷酸(2-5As),后者活化核糖核酸酶L(RNase L),进而抑制DNA病毒和RNA病毒感染。OAS也是细胞内识别病毒双链核糖核酸(dsRNA)的模式识别受体,能够识别具有一定长度或基序特征的病毒dsRNA分子,避免自身免疫应答产生,维持细胞稳态。本文对活化OAS蛋白的dsRNA特征、活化机制、OAS的抗病毒作用以及病毒逃逸OAS-RNase L通路的作用机制进行总结,以期为后续研究提供参考。

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更新日期/Last Update: 2021-05-05