[1]何雪玲,张应花.孤独症细胞模型应用研究进展[J].新乡医学院学报,2019,36(9):801-805.[doi:10.7683/xxyxyxb.2019.09.001]
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孤独症细胞模型应用研究进展
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
36
期数:
2019年9
页码:
801-805
栏目:
国家自然科学基金专题述评
出版日期:
2019-09-05

文章信息/Info

作者:
何雪玲张应花
(新乡医学院基础医学院解剖学教研室 新乡市分子神经病学重点实验室,河南 新乡 453003)
关键词:
孤独症细胞模型细胞系
分类号:
R322.81
DOI:
10.7683/xxyxyxb.2019.09.001
文献标志码:
A
摘要:
孤独症是一种病因复杂的神经发育障碍性疾病,目前已发现很多易感基因,但其病因仍未完全清楚。动物模型是研究孤独症发病机制和治疗手段必不可少的工具,但由于当前动物模型多样化且仅能模拟孤独症的部分表型,因此,近年来细胞模型技术在孤独症的基础研究中得到越来越多的应用。孤独症体外细胞模型种类多样,比较常用的细胞系有肾上腺嗜铬细胞瘤PC12细胞、人神经母细胞瘤SH-SY5Y细胞、原代神经元、淋巴细胞系及诱导的多能干细胞。本文就孤独症细胞模型的应用及其相关病理机制研究进展进行综述。

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更新日期/Last Update: 2019-09-05