[1]任海云,陈志红.肾动脉超声血流动力学指标及晚期氧化蛋白产物在子痫前期孕妇肾功能评价中的临床意义[J].新乡医学院学报,2018,35(6):537-539.[doi:10.7683/xxyxyxb.2018.06.023]
　REN Hai-yun,CHEN Zhi-hong.Clinical significance of renal artery ultrasound hemodynamic index and advanced oxidation protein product in evaluating the renal function level in preeclampsia pregnant women[J].Journal of Xinxiang Medical University,2018,35(6):537-539.[doi:10.7683/xxyxyxb.2018.06.023]
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肾动脉超声血流动力学指标及晚期氧化蛋白产物在子痫前期孕妇肾功能评价中的临床意义
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
35
期数:
2018年6
页码:
537-539
栏目:
临床研究
出版日期:
2018-06-05

文章信息/Info

Title:
Clinical significance of renal artery ultrasound hemodynamic index and advanced oxidation protein product in evaluating the renal function level in preeclampsia pregnant women
作者:
任海云1; 陈志红2
（1.驻马店市中心医院超声科，河南　驻马店　463000；2.驻马店市中心医院检验科，河南　驻马店　463000）
Author(s):
REN Hai-yun1; CHEN Zhi-hong2
（1.Department of Ultrasonography，the Central Hospital of Zhumadian City，Zhumadian 463000，Henan Province，China；2.Department of Laboratory Medicine，the Central Hospital of Zhumadian City，Zhumadian 463000，Henan Province，China）
关键词:
血流动力学; 晚期氧化蛋白产物; 子痫前期; 肾功能
Keywords:
hemodynamics; advanced oxidation protein product; preeclampsia; renal function
分类号:
R714.24+4
DOI:
10.7683/xxyxyxb.2018.06.023
文献标志码:
A
摘要:
目的　探讨肾动脉超声血流动力学指标及晚期氧化蛋白产物（AOPP）在评价子痫前期孕妇肾功能中的临床意义。方法　将驻马店市中心医院2015年3月至2017年3月收治并分娩的72例子痫前期孕妇按照病情程度分为轻度组（39例）和重度组（33例），另选取同期住院并分娩的35例健康孕妇作为对照组，全部孕妇采用彩色多普勒超声测定肾动脉收缩期和舒张期比值（S/D）、搏动指数（PI）和阻力指数（RI），并检测各组孕妇血浆AOPP及血清肌酐（Cr）、尿酸（UA）、胱抑素C（Cys C）、尿素氮（BUN）水平。结果　重度组孕妇肾动脉S/D、PI、RI、血浆AOPP及血清Cr、Cys C、BUN水平均显著高于轻度组和对照组（P<0.05）；轻度组孕妇肾动脉S/D、PI、RI、血浆AOPP及血清Cys C水平显著高于对照组（P<0.05），血清Cr、BUN水平与对照组比较差异无统计学意义（P>0.05）。3组孕妇血清UA水平两两比较差异无统计学意义（P>0.05）。Pearson相关性分析结果显示，肾动脉S/D、PI、RI、血浆AOPP与血清Cys C水平呈显著正相关（r=0.557、0.621、0.597、0.608，P<0.05），与血清Cr、UA、BUN水平无相关性（r=0.133、0.159、0.215，P>0.05）。肾动脉S/D、PI、RI与血浆AOPP水平亦呈显著正相关（r=0.582、0.639、0.633，P<0.05）。结论　肾动脉超声血流动力学指标及AOPP水平检测能为判断子痫前期孕妇的肾功能提供帮助。
Abstract:
Objective　To explore the clinical significance of renal artery ultrasound hemodynamic index and advanced oxidation protein product（AOPP） in evaluating the renal function level in preeclampsia pregnant women.Methods　Seventy two cases of preeclampsia pregnant women in the Central Hospital of Zhumadian City were divided into mild group（39 cases） and severe group（33 cases） according to the pathogenetic condition，and 35 healthy pregnant women who were hospitalized and delivered in the same period were selected as the control group.Ratio of systolic to diastolic（S/D），pulsation index（PI），resistance index（RI） of renal artery were detected by color Doppler ultrasound in all patients.The levels of plasma AOPP and serum creatinine（Cr），uric acid（UA），cystatin C（Cys C），blood urea nitrogen（BUN）were detected.The results among the three groups were analyzed.Results　The S/D，PI，RI of renal artery,the levels of plasma AOPP and serum Cr，Cys C，BUN in the severe group were significantly higher than those in the mild group and the control group（P<0.05）.The S/D，PI，RI of renal artery,the levels of plasma AOPP and serum Cys C in the mild group were significantly higher than those in the control group（P<0.05）.There was no significant difference in the level of serum Cr and BUN between the mild group and the control group（P>0.05）.There was no significant difference in the serum UA level among the three groups（P>0.05）.The results of Pearson correlation analysis showed that the S/D，PI，RI of renal artery and AOPP were positively correlated with the level of Cys C（r=0.557，0.621，0.597，0.608；P<0.05），but they was not correlated with the level of serum Cr，UA and BUN（r=0.133，0.159，0.215；P>0.05）.The S/D，PI，RI of renal artery were positively correlated with the level of plasma AOPP（r=0.582，0.639，0.633；P<0.05）.Conclusion　Detection of renal artery hemodynamic parameters and AOPP level can help to predict renal function in preeclampsia pregnant women.

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更新日期/Last Update: 2018-06-05