[1]章昌敏.丹栀逍遥胶囊联合亮醋酸丙瑞林治疗儿童中枢性性早熟疗效观察[J].新乡医学院学报,2017,34(12):1104-1106.[doi:10.7683/xxyxyxb.2017.12.015]
　ZHANG Chang-min.Danzhi Xiaoyao capsule combined with leuprorelin acetate for treatment of central precocious puberty in children[J].Journal of Xinxiang Medical University,2017,34(12):1104-1106.[doi:10.7683/xxyxyxb.2017.12.015]
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丹栀逍遥胶囊联合亮醋酸丙瑞林治疗儿童中枢性性早熟疗效观察
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年12
页码:
1104-1106
栏目:
临床研究
出版日期:
2017-12-05

文章信息/Info

Title:
Danzhi Xiaoyao capsule combined with leuprorelin acetate for treatment of central precocious puberty in children
作者:
章昌敏
（信阳市中心医院儿科，河南　信阳　464000）
Author(s):
ZHANG Chang-min
（Department of Pediatrics，Xinyang Central Hospital，Xinyang 464000，Henan Province，China）
关键词:
中枢性性早熟; 丹栀逍遥胶囊; 醋酸亮丙瑞林
Keywords:
central precocious puberty; Danzhi Xiaoyao capsule; leuprolide acetate
分类号:
R725.8
DOI:
10.7683/xxyxyxb.2017.12.015
文献标志码:
A
摘要:
目的　探讨丹栀逍遥胶囊联合醋酸亮丙瑞林治疗儿童中枢性性早熟（CPP）的临床疗效。方法　选取2015年3月至2016年12月在信阳市中心医院就诊的CPP女性患儿106例，采用随机数字表法将其分为对照组和观察组，每组53例。对照组患儿皮下注射醋酸亮丙瑞林，观察组患儿在对照组治疗基础上加用丹栀逍遥胶囊。比较2组患儿治疗后卵巢体积、子宫体积、骨龄指数、性激素水平、身高增速的变化以及临床疗效和不良反应。结果　治疗前2组患儿卵巢体积、子宫体积、骨龄指数比较差异均无统计学意义（P>0.05）；治疗后，2组患儿卵巢体积、子宫体积、骨龄指数均显著低于治疗前（P<0.05），且观察组患儿卵巢体积、子宫体积、骨龄指数均显著低于对照组（P<0.05）。治疗前2组患儿血清中黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E2）水平比较差异无统计学意义（P>0.05）；治疗后，2组患儿血清中LH、FSH、E2水平均较治疗前显著降低（P<0.05），且观察组患儿血清中LH、FSH、E2水平均显著低于对照组（P<0.05）。观察组患儿身高增速为（4.52±0.83）cm·a-1，显著低于对照组患儿的（7.35±1.02）cm·a-1（P<0.05）。观察组患儿治疗总有效率为92.45%，显著高于对照组患儿的73.58%（χ2=6.692，P<0.05）。治疗期间2组患儿均未出现不良反应。结论　丹栀逍遥胶囊联合醋酸亮丙瑞林治疗儿童CPP疗效显著，不良反应少，可有效调节机体性激素，延迟发育时间。
Abstract:
Objective　To explore the clinical efficacy of Danzhi Xiaoyao capsule combined with leuprolide acetate for treatment of central precocious puberty（CPP） in children.Methods　One hundred and six female children with CPP in Xinyang Central Hospital from March 2015 to December 2016 were selected and divided into control group and observation group by random digits table，with 53 children in each group.The children in the control group were given leuprolide acetate subcutaneously；based on this，the children in the observation group were given Danzhi Xiaoyao capsule.After treatment，the ovarian volume，uterine volume，bone age index，sex hormone，height change，clinical efficacy and adverse reactions of children were compared between the two groups.Results　Before treatment，there was no statistic difference in the ovarian volume，uterine volume and bone age index of children between the two groups（P>0.05）；the ovarian volume，uterine volume and bone age index of children in the two groups after treatment were significantly lower than those before treatment （P<0.05）；the ovarian volume，uterine volume and bone age index of children in the observation group were significantly lower than those in the control group （P<0.05）.Before treatment，there was no statistic difference in the luteotropic hormone （LH），follicle-stimulating hormone （FSH） and estradiol（E2） levels of children between the two groups （P>0.05）；the LH，FSH and E2 levels of children in the two groups after treatment were significantly lower than those before treatment （P<0.05）；the LH，FSH and E2 levels of children in the observation group were significantly lower than those in the control group （P<0.05）.The height growth speed of children in observation group ［（4.52±0.83）cm·a-1］ was significantly lower than that in control group［（7.35±1.02）cm·a-1 ］（P<0.05）.The total effective rate of children in observation group （92.45%） was significantly higher than that of control group （73.58%） （χ2=6.692，P<0.05）.There was no adverse effects in the two groups during treatment.Conclusion　Danzhi Xiaoyao capsule combined with leuprolide acetate for treatment of central precocious puberty in children has evident effect，less adverse reactions；it can effectively regulate the sex hormones levels of body，and delay the growth time.

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更新日期/Last Update: 2017-12-05