[1]张卫国.急性ST段抬高型心肌梗死患者血浆血红素加氧酶-1水平与急诊经皮冠状动脉介入术后无复流的关系[J].新乡医学院学报,2017,34(7):651-653.[doi:10.7683/xxyxyxb.2017.07.026]
　ZHAGN Wei-guo.Relationship between heme oxygenase-1 levels in patients with ST-segment elevation myocardial infarction and non-reflow after emergency percutaneous coronary intervention[J].Journal of Xinxiang Medical University,2017,34(7):651-653.[doi:10.7683/xxyxyxb.2017.07.026]
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急性ST段抬高型心肌梗死患者血浆血红素加氧酶-1水平与急诊经皮冠状动脉介入术后无复流的关系
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年7
页码:
651-653
栏目:
临床研究
出版日期:
2017-07-05

文章信息/Info

Title:
Relationship between heme oxygenase-1 levels in patients with ST-segment elevation myocardial infarction and non-reflow after emergency percutaneous coronary intervention
作者:
张卫国
（郑州大学第二附属医院心内科，河南　郑州　450000）
Author(s):
ZHAGN Wei-guo
（Department of Cardiology，the Second Affiliated Hospital of Zhengzhou University，Zhengzhou 450000，Henan Province，China）
关键词:
心肌梗死; 血红素加氧酶-1; 经皮冠状动脉介入术; 无复流
Keywords:
myocardial infarction; heme oxygenase -1; percutaneous coronary intervention; non-reflow
分类号:
R714.252
DOI:
10.7683/xxyxyxb.2017.07.026
文献标志码:
A
摘要:
目的　探讨急性ST段抬高型心肌梗死（STEMI）患者血浆血红素加氧酶-1（HO-1）水平与急诊经皮冠状动脉介入术（PCI）后无复流的关系。方法　选择2010年10月至2013年3月于郑州大学第二附属医院行PCI的STEMI患者80例，根据患者PCI术后ST段回落水平分为2组，ST段回落值<50%定义为无复流阳性组，ST回落值≥50%者为无复流阴性组。比较2组患者低密度脂蛋白胆固醇（LDL）、高密度脂蛋白胆固醇（HDL）、肌酐、高敏C反应蛋白（hs-CRP）、HO-1水平及临床特征。以受试者工作特征（ROC）曲线计算血浆HO-1水平预测无复流发生的阈值及无复流发生的危险因素。结果　无复流阳性组患者血浆HO-1水平显著高于无复流阴性组（P<0.001），经ROC回归分析显示，血浆HO-1水平≥ 24.15 mg·L-1在预测无复流发生的敏感性为66.7%，特异性为89.8%。多因素分析结果表明，血浆HO-1水平和胸痛时间超过6 h是PCI后发生无复流的独立预测因子。结论　入院时血浆HO-1水平作为一项生物学标志物可能具有预测急性STEMI急诊PCI后无复流发生的作用。
Abstract:
Objective　To investigate the association between heme oxygenase-1 （HO-1） levels in patients with ST-segment elevation myocardial infarction （STEMI） and non-reflow after emergency percutaneous coronary intervention（PCI）.Methods　Eighty patients with STEMI were selected from October 2010 to March 2013 in the Second Affiliated Hospital of Zhengzhou University.The patients were treated with emergency percutaneous coronary intervention （PCI）.The patients were divided into two groups according to the fall after rise level of ST segment after PCI，the patients with the ST segment dropped less than 50% were rolled in non-reflow negative group，and the patients with the ST segment dropped great than or equal to 50% were rolled in non-reflow positive group.Low density lipoprotein cholesterol，high density lipoprotein cholesterol，creatinine，high sensitivity C-reactive protein，HO-1 and clinical features were compared between the two groups.The threshold of no-reflow and risk factors for no-reflow were predicted by plasma HO-1 levels using the receiver operating characteristic curve（ROC）.Results　HO-1 level in the non-reflow positive group was significantly higher than that in the non-reflow negative group（P<0.001），the ROC regression analysis showed that plasma HO-1 more than 24.15 mg·L-1could predict non-reflow，the sensitivity was 66.7%，specificity was 89.8%.Multifactor analysis showed that the HO-1 level and chest pain time over than 6 hours were independent predictors of the non-reflow after emergency PCI.Conclusion　Plasma HO-1 can be used to predicting non-reflow after emergency PCI as a biomarker.

参考文献/References:

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更新日期/Last Update: 2017-07-05