[1]尚　云,杨卫红,任　芳,等.缺氧缺血性脑病新生儿血清白细胞介素-6和S-100β蛋白水平变化及临床意义[J].新乡医学院学报,2017,34(5):378-380.[doi:10.7683/xxyxyxb.2017.05.008]
　SHANG Yun,YANG Wei-hong,REN Fang,et al.Changes of interleukin-6 and S-100β protein in neonates with hypoxic-ischemic encephalopathy and their clinical significance[J].Journal of Xinxiang Medical University,2017,34(5):378-380.[doi:10.7683/xxyxyxb.2017.05.008]
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缺氧缺血性脑病新生儿血清白细胞介素-6和S-100β蛋白水平变化及临床意义
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《新乡医学院学报》[ISSN:1004-7239/CN:41-1186/R]

卷:
34
期数:
2017年5
页码:
378-380
栏目:
临床研究
出版日期:
2017-05-05

文章信息/Info

Title:
Changes of interleukin-6 and S-100β protein in neonates with hypoxic-ischemic encephalopathy and their clinical significance
作者:
尚　云1; 杨卫红1; 任　芳2; 马慧敏3; 郭喜霞4; 唐成和1
（1.新乡医学院第一附属医院新生儿科，河南　卫辉　453100；2.新乡医学院第一附属医院急诊科，河南　卫辉　453100；3.新乡医学院第一附属医院耳鼻喉科，河南　卫辉　453100；４.新乡医学院第一附属医院儿内3科，河南　卫辉　453100）
Author(s):
SHANG Yun1; YANG Wei-hong1; REN Fang2; MA Hui-min3; GUO Xi-xia4; TANG Cheng-he1
（1.Department of Neonatology，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province；2.Department of Emergency，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province；3.Department of Otolaryngology，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province；4.The Third Department of Pediatrics，the First Affiliated Hospital of Xinxiang Medical University，Weihui 453100，Henan Province）
关键词:
缺氧缺血性脑病; 白细胞介素-6; S-100β
Keywords:
hypoxic ischemic encephalopathy; interleukin-6; S-100β
分类号:
R272.1
DOI:
10.7683/xxyxyxb.2017.05.008
文献标志码:
A
摘要:
目的　探讨缺氧缺血性脑病（HIE）新生儿血清中白细胞介素-6（IL-6）、S-100β蛋白水平的变化及意义。方法　选取2011年2月至2013年2月新乡医学院第一附属医院新生儿科临床确诊的HIE患儿74例为观察组，其中轻度31例，中度26例，重度17例；预后良好32例，预后不良42例；另选取同期正常健康新生儿74例为对照组，于生后48 h应用酶联免疫吸附法检测2组新生儿血清IL-6及S-100β蛋白水平。结果　观察组患儿出生后48 h，血清IL-6、S-100β蛋白表达水平均显著高于对照组（P<0.05）；重度HIE组患儿IL-6、S-100β蛋白水平均高于中度HIE组和轻度HIE组，中度HIE组患儿IL-6、S-100β蛋白水平均高于轻度HIE组（P<0.05）；与预后良好HIE患儿比较，预后不良HIE患儿血清IL-6、S-100β蛋白表达水平增高（P<0.05）。IL-6及S-100β蛋白表达均与HIE严重程度（r=1.071、0.801，P<0.05）及预后存在正相关（r=1.021、0.742，P<0.05）。结论　IL-6和S-100β蛋白均参与了HIE的病理生理过程，二者在血液中的水平与该病病情程度及预后相关，动态监测二者变化趋势将有助于HIE的病情程度判断及预后评估。
Abstract:
Objective　To investigate the changes and the significance of interleukin-6（IL-6）and S-100β in neonates with hypoxic-ischemic encephalopathy（HIE）.Methods　Seventy-four newborn with HIE in Neonatology Department of the First Affiliated Hospital of Xinxiang Medical University from February 2011 to February 2013 were selected as observation group，which included 31 cases of mild HIE，26 cases of moderate HIE，17 cases of severe HIE；32 cases of good prognosis，42 cases of poor prognosis.Seventy-four healthy newborn were selected as control group.The levels of IL-6 and S-100β protein in all samples were measured at postnatal 48 hours by enzyme linked immunosorbent assay method.Results　The levels of IL-6 and S-100β protein at postnatal 48 hours in observation group were higher than those in control group（P<0.05）.The levels of IL-6 and S-100β protein in severe HIE group were higher than those in moderate HIE group and mild HIE group，while in moderate HIE group they were higher than those in mild HIE group（P<0.05）.The levels of IL-6 and S-100β protein in poor prognosis group were higher than those in favourable prognosis group（P<0.05）.Furthermore，there were positive correlations between the levels of IL-6 and S-100β protein and the clinical grading（r=1.071，0.801；P<0.05）and prognosis（r=1.021，0.742；P<0.05）.Conclusion　IL-6 and S-100β protein were involved in the pathophysiological process of HIE.The levels of them were closely related to the severity and disease progression of HIE.Dynamic monitoring the changes of them is conducive to assess the severity and predict the prognosis of HIE.

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更新日期/Last Update: 2017-05-05